IGF/IGF-1R
Combined treatment with metformin and gefitinib overcomes primary resistance to EGFR-TKIs with EGFR mutation via targeting IGF-1R signaling pathway
... of IGF-1R activity by AG-1024 (a small molecule of IGF-1R inhibitor), as well as downregulation of IGF-1R by siRNA, significantly enhanced the ability of Gef to suppress ...
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A kinase-independent biological activity for insulin growth factor-1 receptor (IGF-1R): implications for inhibition of the IGF-1R signal
... the IGF-1R tyrosine kinase inhibitor OSI-906 did not affect intracellular glucose ...addition, IGF-1R interacted with SGLT1 in a manner similar to that previously reported with ...of ...
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HRD1 suppresses the growth and metastasis of breast cancer cells by promoting IGF-1R degradation
... HRD1 (3-hydroxy-3-methylglutaryl reductase degradation) is an E3 ubiquitin ligase. We found that HRD1 was significantly downregulated in 170 breast cancer tissues. Low tumoral HRD1 expression was correlated with ...
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An Autocrine IL-6/IGF-1R Loop Mediates EMT and Promotes Tumor Growth in Non-small Cell Lung Cancer
... and IGF-1R were ...inhibiting IGF-1R, suggesting that IGF-1R might signal via ...of IGF-1R and AKT was inhibited by blocking STAT3, suggesting that STAT3 blockade ...
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The impact of IGF-1R expression on the outcomes of patients with breast cancer: a meta-analysis
... detecting IGF-1R expression in the primary breast cancer and analyzed patient survival data according to IGF-1R ...of IGF-1R-positive ...of IGF-1R on overall ...
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Does Metformin affect ER, PR, IGF-1R, β-catenin and PAX-2 expression in women with diabetes mellitus and endometrial cancer?
... local IGF-1 production ...to IGF-1 reduces its bioavailable fraction. Mitogenic function of IGF-1 may occur through different mediators, the dominant pathway being PI3K/Akt, but also MAPK, both ...
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ERG deregulation induces IGF-1R expression in prostate cancer cells and affects sensitivity to anti-IGF-1R agents
... anti-IGF- 1R agents for patients expressing the fusion ...of IGF-1R to prostate carcinogenesis and progression remains controversial, but epidemiological, preclinical and clinical results ...
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Role of IGF-1/IGF-1R in regulation of invasion in DU145 prostate cancer cells
... ON). IGF-1 was obtained lyophilized from Sigma-Aldrich and reconstituted in dis- tilled ...an IGF-1R neutralizing antibody, MAB391 (R&D Systems, ...
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Original Article IGF-1R promotes the expression of cyclin D1 protein and accelerates the G1/S transition by activating Ras/Raf/MEK/ERK signaling pathway
... of IGF-1R in the breast cancer tis- sues may play an important role in the carcino- genesis and development of breast ...of IGF-1R expression on the proliferation and apoptosis of MCF-7 ...of ...
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Age-Dependent Neuroimmune Modulation of IGF-1R in the Traumatic Mice
... of IGF-1R/Fyn signaling by MOR in the traumatic ...with IGF-1. Thus, 5 groups of mice were created: Con, T1, T1 + IGF-1, T3, T3 + IGF-1 (n = 5 for each ...of IGF-1R and ...
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Crosstalk between the IGF-1R/AKT/mTORC1 pathway and the tumor suppressors p53 and p27 determines cisplatin sensitivity and limits the effectiveness of an IGF-1R pathway inhibitor
... reduced IGF-1R/AKT/mTORC1 activation, indicating that p53 contributes to IGF-1R/AKT/ mTORC1 activation in CP-treated OS ...increase IGF-1R/AKT/ mTORC1 activation by increasing ...
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Polymorphisms of AluI and Hin1I loci of the IGF-1R gene and their genetic effects on growth traits in Bian chickens.
... the IGF-1R gene of Bian ...the IGF-1R gene resulted in three genotypes AA, AB, and ...the IGF-1R gene resulted in three genotypes CC, CD, ...
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Associations among IGF-1, IGF2, IGF-1R, IGF-2R, IGFBP-3, insulin genetic polymorphisms and central precocious puberty in girls
... the IGF-1R + 1013 (AG) and IGF-2 + 3580 (AG + AA) groups were more advanced in the EP ...that IGF-1R and IGF-2 + 3580 were related to precocious puberty in girls, our results ...
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The expression and significance of insulin like growth factor 1 receptor and its pathway on breast cancer stem/progenitors
... the IGF-1R, leading to reduced phosphorylation of Akt Ser473 and decreased ALDH + BCSC ...circulating IGF-1 was associated with a greater risk of several cancers, including breast cancer ...between ...
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Silencing of the type 1 insulin-like growth factor receptor increases the sensitivity to apoptosis and inhibits invasion in human lung adenocarcinoma A549 cells
... to IGF-1R inhibited breast cancer growth via the inactivation of the PI-3K/Akt and p42/p44 MPAK signaling pathways ...of IGF-1R blocked the phosphorylation of Akt-1 and p38, but not of ERK1/2, ...
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Original Article Insulin-like growth factor-1 protects ischemic myocardial cells via PI3K/AKT pathway
... by IGF-1 contains two canonical pathways, which one is the PI3K/AKT pathway ...of IGF-1 in ischemic cells has been described ...overexpressing IGF-1R in mice, IGF-1-dependent ischemia ...
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Effects of insulin analogs and glucagon-like peptide-1 receptor agonists on proliferation and cellular energy metabolism in papillary thyroid cancer
... of IGF-1R and GLP-1R were more obvious in PTC than in normal thyroid ...IR, IGF-1R, and GLP-1R. However, insulin analogs and GLP-1R agonists, which are commonly used to ...
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Targeting insulin-like growth factor axis in hepatocellular carcinoma
... of IGF axis that provides mitogenic sig- nal for tumor ...blocks IGF-1R, both in vitro and in vivo ...of IGF-1R as shown by the suppression of phosphorylated AKT and phosphorylated S6 ...
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The insulin-like growth factor-binding protein (IGFBP) family and its role in obesity and cancer
... of IGF need a complex system to act, often, it is known as the IGF “axis” ...as IGF-type 1 (IGF-1) and IGF-type 2 (IGF-2), two cell-surface re- ceptors such as ...
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The Insulin-like Growth Factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endothelium.
... of IGF-1R are glucose-intolerant but have enhanced insulin- mediated glucose lowering and increased basal and insulin-stimulated NO ...production. IGF-1R +/2 mice had similar fasting glucose ...
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