IGFBP -1 to -4
Massive hepatic apoptosis associated with TGF β1 activation after Fas ligand treatment of IGF binding protein 1–deficient mice
... whether IGFBP-1 can also protect against liver injury. IGFBP-1 is a member of a group of structurally related soluble proteins that specifically bind and modulate the actions of IGF-1 ...
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Original Article IGFBP-3 may trigger osteoarthritis by inducing apoptosis of chondrocytes through Nur77 translocation
... including IGFBP-2, IGFBP-3, IGFBP-4, especially the middle one elevated ...of IGFBP-3 were observed by Whellams in the OA synovial fluid [6] and he thought maybe there were a ...
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Common genetic variation in IGF1, IGFBP 1, and IGFBP 3 in relation to mammographic density: a cross sectional study
... and IGFBP-3 levels inversely with mammographic density in premenopausal women [15-17], although no association has been observed in postmenopau- sal women ...
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Molecular Mechanisms Linking Amino Acid (Leucine) Deprivation to IGFBP-1 Hyperphosphorylation in Fetal Growth Restriction
... induce IGFBP-1 phosphorylation prompted the investigation of the ...availability 4 , and is known to be systemically involved in mediating the stress response to nutritional insufficiency to ...
206
Genetic and environmental components of interindividual variation in circulating levels of IGF I, IGF II, IGFBP 1, and IGFBP 3
... at 4 8 C, Europium-labeled IGF-II (2 ng/50 m l) was added to the wells and incubated for another 40 min at room ...with 1 mg/ml of IGF-I (Austral Biolog- icals), IGFBP-1 (16), IGFBP-3 ...
5
Prognostic value of the Stanniocalcin-2/PAPP-A/IGFBP-4 axis in ST-segment elevation myocardial infarction
... intact IGFBP-4 can be interpreted as a regulatory response to high PAPP-A proteolytic activity, The specific mechanisms in STEMI patients warrant further ...
9
Excessive gestational weight gain and obesity contribute to altered expression of maternal insulin-like growth factor binding protein-3
... at 4 ° C overnight, followed by antibody highly specific to IGFBP-1 (#sc55474; Santa Cruz Biotech) and IGFBP-3 (#sc135947; Santa Cruz Biotech) and finally by streptavidin-HRP (GE Healthcare, ...
9
Expression and clinical significance of IGF-1, IGFBP-3, and IGFBP-7 in serum and lung cancer tissues from patients with non-small cell lung cancer
... in 4% formalin for histopathologic ...at 4 ° C until ...IGF-1, IGFBP-3, and ...at 4 ° C. Mouse primary monoclonal antibodies directed against IGF-I, IGFBP-3, and IGFBP-7 ...
8
Uterine receptivity and implantation: The regulation and action of insulin-like growth factor binding protein-1 (IGFBP-1), HOXA10 and forkhead transcription factor-1 (FOXO-1) in the baboon endometrium
... Uterine receptivity and implantation in the baboon can be categorized into three distinct phases. Phase I is regu- lated by estrogen and progesterone and is evident between days 8 and 10 post-ovulation (PO) of the normal ...
6
Altered placental development and intrauterine growth restriction in IGF binding protein 1 transgenic mice
... exploring IGFBP-1 function in placentation, we undertook the present study using transgenic mice with targeted over- expression of IGFBP-1 in the ...human IGFBP-1 structural gene ...
9
Serum IGF-1, IGFBP-3 and their ratio: Potential biochemical growth maturity indicators
... IGF- 1 has been correlated with pubertal growth spurt [21]. IGF-1 levels have been proposed as an alternative method to detect pubertal growth spurt timing in com- parison to Cervical Vertebrae Maturity ...
8
Evolution of ancient functions in the vertebrate insulin like growth factor system uncovered by study of duplicated salmonid fish genomes
... between IGFBP expression level and the number of a ...the IGFBP-3/-5/-6 metaclade and IGFBP-4 were more highly expressed than IGFBP-1 and -2 in gill, skin, heart, and fast ...
17
Involvement of p53 in insulin-like growth factor binding protein-3 regulation in the breast cancer cell response to DNA damage
... the IGFBP-3 ...induced IGFBP-3 mRNA in response to the drug, while MDA- MB-468 cells, with a much weaker apoptotic response, downregulated IGFBP-3 mRNA and protein in response to ...which ...
16
Effects of 8 Weeks of Resistance Training and IGF-1 Injection on Biochemical Markers of Cancer and Colorectal Structures in Rats
... low IGFBP-3 levels increase the risk of colorectal cancer and villous adenomas ...IGF-1, IGFBP-3 and IGF-1/IGFBP-3 ...and IGFBP-3 concentrations in rats, and studied possible ...
7
Raised serum levels of IGFBP-1 and IGFBP-2 in idiopathic pulmonary fibrosis
... Idiopathic pulmonary fibrosis (IPF) is a complex diagno- sis and pathology requiring a multidisciplinary approach. This fibrotic disease has a poor prognosis and requires a specific and early appropriate therapy ...
7
Investigation of insulin like growth factors/insulin like growth factor binding proteins regulation in metabolic syndrome patients
... Additionally, in our survey, there was a positive corre- lation between serum IGF-1 level and IGF-2 (p < 0.05), serum IGFBP-3 and IGF-2 (p < 0.05), and between the age of participants with serum ...
5
Transcriptional regulation of the IGF signaling pathway by amino acids and insulin like growth factors during myogenesis in Atlantic salmon
... (B), IGFBP-4 (C), IGFBP-5.1 (D), IGFBP-5.2 (E) and IGFBP-6 (F) in day 9 myogenic cells starved for 72 h, then treated with various combinations of amino acids, IGFs and insulin or ...
14
Original Article IGF-1 and IGFBP-3 polymorphisms predict risk for non-traumatic osteonecrosis of the femoral head
... and IGFBP-3 rs924140, rs2453839 in control group and case group, so as to explore the association of IGF-1 and IGFBP-3 gene poly- morphism with NONFH ...and IGFBP-3 rs924140 poly- morphism is ...
8
IGFBP-4 tumor and serum levels are increased across all stages of epithelial ovarian cancer
... average IGFBP-4 levels ~3× higher than benign masses (Figure ...of IGFBP-4 alone or in combination with other markers for distinguishing between benign and malignant ...
8
Neocortical tissue recovery in severe congenital obstructive hydrocephalus after intraventricular administration of bone marrow-derived mesenchymal stem cells
... using 1 H High-Resolution Magic Angle Spinning Nuclear Magnetic Resonance ( 1 H HR-MAS NMR) spectroscopy, thus allowing the detection of metabolites/osmolytes related with hydrocephalus severity and outcome ...
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