IGFBP-1 to -6
Evolution of ancient functions in the vertebrate insulin like growth factor system uncovered by study of duplicated salmonid fish genomes
... ing IGFBP proteolysis and the association of IGFBPs with cell-surfaces and extracellular matrixes (Clemmons ...all IGFBP family members are effi- cient carriers of circulating/interstitial IGF, they have ...
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Involvement of p53 in insulin-like growth factor binding protein-3 regulation in the breast cancer cell response to DNA damage
... the IGFBP-3 ...induced IGFBP-3 mRNA in response to the drug, while MDA- MB-468 cells, with a much weaker apoptotic response, downregulated IGFBP-3 mRNA and protein in response to ...which ...
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Detection and correlation analysis of serum cytokines in non-small-cell lung cancer patients with bone and non-bone metastases
... The 13 cytokines in serum that may be related to bone metas- tasis were tested and divided into two types based on different functions. The first type was homing chemokines and cytokines that make the tumor cells migrate ...
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Altered placental development and intrauterine growth restriction in IGF binding protein 1 transgenic mice
... fetal and maternal tissues and amniotic fluid at different stages of gestation. Successful matings were indicated by the appearance of a vaginal copulation plug. Midday on the day the copulation plug was observed was ...
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Effects of 8 Weeks of Resistance Training and IGF-1 Injection on Biochemical Markers of Cancer and Colorectal Structures in Rats
... (4, 6), while high IGF1 level is associated with an increased risk of colorectal cancer ...low IGFBP-3 levels increase the risk of colorectal cancer and villous adenomas ...IGF-1, IGFBP-3 and ...
7
Effects of Hibiscus sabdariffa Linn. on Malondialdehyde and Glutathione Peroxidase in an Overtraining Rat Model characterized by Growth Hormone, Insulin-like Growth Factor-1, and Insulin-like Growth Factor Binding Protein-3
... after 6 hours, post workout because of the negative feedback mechanism of the axis ...IGF 1. Decrease in GH will correlate with a decrease in IGF-1, but in this study, we found a tendency of ...
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Molecular Mechanisms Linking Amino Acid (Leucine) Deprivation to IGFBP-1 Hyperphosphorylation in Fetal Growth Restriction
... phosphorylating IGFBP-1 at Ser101, Ser119 and Ser169 in HepG2 cells, however, future CK2:IGFBP-1binding studies would clarify whether IGFBP-1 is a true CK2 ...hand, ...
206
Investigation of insulin like growth factors/insulin like growth factor binding proteins regulation in metabolic syndrome patients
... growth factor binding proteins (IGFBPs) contribute to other critical metabolic pathways, namely IGF/insulin- dependent pathway and IGF/insulin-independent path- way [4, 5]. Previous reports have shown that the elements ...
5
Original Article IGFBP-3 may trigger osteoarthritis by inducing apoptosis of chondrocytes through Nur77 translocation
... of IGFBP-3 is plausibly explained by two existent theories: (1) IGFBP-3 integrates the death receptors (TGF- βRV, LRP-1 and Stat1) directly, activating Caspase-8 then the Caspase-3 pathway, ...
12
Common genetic variation in IGF1, IGFBP 1, and IGFBP 3 in relation to mammographic density: a cross sectional study
... block 1 and mammographic density (p = ...file 1). None of the three haplotype blocks in the genes encoding IGFBP-1/IGFBP-3 were significantly associated with mammographic density in ...
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Uterine receptivity and implantation: The regulation and action of insulin-like growth factor binding protein-1 (IGFBP-1), HOXA10 and forkhead transcription factor-1 (FOXO-1) in the baboon endometrium
... Uterine receptivity and implantation in the baboon can be categorized into three distinct phases. Phase I is regu- lated by estrogen and progesterone and is evident between days 8 and 10 post-ovulation (PO) of the normal ...
6
Interaction between the insulin like growth factor family and the integrin receptor family in tissue repair processes Evidence in a rabbit ear dermal ulcer model
... whereby IGFBP-1 is able to enhance IGF-I bioactivity. As IGFBP-1 binds both the a 5 b 1 integrin as well as IGF-I in vitro, we asked which of the following interactions were important: ...
8
Genetic and environmental components of interindividual variation in circulating levels of IGF I, IGF II, IGFBP 1, and IGFBP 3
... with 1 mg/ml of IGF-I (Austral Biolog- icals), IGFBP-1 (16), IGFBP-3 (Celtrix Pharmaceuticals) and IG- FBP-2, -4, -5, -6 (Austral ...IGFBPs 1 to 6 and IGF-I did not ...
5
Serum IGF-1, IGFBP-3 and their ratio: Potential biochemical growth maturity indicators
... serum IGFBP-3 were lowest at CVMI1 stage of cervical development with mean values of 3056 ± ...(Table 1). Thereafter, serum IGFBP-3 levels showed a sharp rise from CVMI2 o CVMI3 with a mean value of ...
8
Original Article IGF-1 and IGFBP-3 polymorphisms predict risk for non-traumatic osteonecrosis of the femoral head
... of IGFBP-3 rs924140 can significantly reduce the risk of ...The IGFBP family can regulate the growth and metabolism of bone cells and is closely related to bone necrosis ...[23]. IGFBP-3, as a part ...
8
Journal of Applied Pharmaceutical Science
... high-affinity IGFBP-1 to IGFBP-6 are secretable proteins, synthesized and secreted by different organs and multiple target tissues in a paracrine/autocrine fashion and are in fact considered ...
8
Raised serum levels of IGFBP-1 and IGFBP-2 in idiopathic pulmonary fibrosis
... Lungen 6 or KL-6, Ig A and periostin [4 – 8] were studied without much success to be discriminant as early diagnostic biomarkers to identify IPF out of different interstitial lung diseases ...
7
Investigation of β-Catenin-Mediated Regulation of IGFBP-6 and the Roles of IGFBP-6 and IGF-II in Dupuytren's Disease
... preparation using the NEBNext ChIP-Seq Library Prep Master Mix Set for Illumina (New England Biolabs) and the manufacturer’s protocol was followed with size selection using AmpureXP Beads. Briefly, ChIP DNA was ...
171
Transcriptional regulation of the IGF signaling pathway by amino acids and insulin like growth factors during myogenesis in Atlantic salmon
... and IGFBP expression by amino acids and insulin-like growth factors was also ...5.2, IGFBP-6, IGFBP-rP1, ...(IGF-I, IGFBP-4, FGF2 and IGF-IRb) and terminal differentiation and myotube ...
14
IGFBP-2 and -3 co-ordinately regulate IGF1 induced matrix mineralisation of differentiating human dental pulp cells
... study IGFBP-2 levels were approximately 10-fold higher than those of IGFBP-3 suggesting that the large induction of IGFBP-2 may play a more import role in the differentiation of DPCs than the ...
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