IGFBP-3
Genetic and environmental components of interindividual variation in circulating levels of IGF I, IGF II, IGFBP 1, and IGFBP 3
... serum IGFBP-3 levels compared with previous studies ...the IGFBP-3 levels was much higher than for the IGF-I levels but not as high as for the IGF-II ...and IGFBP-3 (21). ...
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Activation of Various Downstream Signaling Molecules by IGFBP 3
... of IGFBP-3 resulted in the activation of Smad 2 phosphorylation and cell growth inhibition in these ...that IGFBP-3 mediates its pro-apoptotic effects via TGF-β in PC-3 human prostate ...
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Pancreatic cancer cell-derived IGFBP-3 contributes to muscle wasting
... endogenous IGFBP-5 has been shown to promote myogenesis via activation of IGF- 2/AKT/FoxO signaling, whereas, IGFBP-5 overexpres- sion tremendously causes retarded muscle develop- ment [19, ...that ...
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Monitoring serum insulin-like growth factor-I (IGF-I), IGF binding protein-3 (IGFBP-3), IGF-I/IGFBP-3 molar ratio and leptin during growth hormone treatment for disordered growth
... In GHD adults, considerable variability in responsiveness to GH, and relationships with GH dose, pretreatment GHBP levels, age and gender have been observed for different GH effects (including increase in serum IGF-I ...
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Original Article IGF-1 and IGFBP-3 polymorphisms predict risk for non-traumatic osteonecrosis of the femoral head
... of IGFBP-3 rs924140 can significantly reduce the risk of ...The IGFBP family can regulate the growth and metabolism of bone cells and is closely related to bone necrosis ...[23]. ...
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Common genetic variation in IGF1, IGFBP 1, and IGFBP 3 in relation to mammographic density: a cross sectional study
... Block 3 was associated with mammographic density in a global test of association (p = ...encoding IGFBP-1/IGFBP-3 were significantly associated with mammographic density in global tests of ...
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Original Article IGFBP-3 may trigger osteoarthritis by inducing apoptosis of chondrocytes through Nur77 translocation
... that IGFBP-3 exerted cell apoptosis by IGF-1 independent effect, those announcements were all based on malignant cell ...reported IGFBP-3 may inhibit apoptosis in normal cell rather than ...
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Serum IGF-1, IGFBP-3 and their ratio: Potential biochemical growth maturity indicators
... untreated serum samples give false values because of the extremely slow dissociation of the IGF-1/IGFBP-3 com- plexes during the assay incubation. However, various techniques have been applied to physically ...
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<p>IGFBP-3 Is the Key Target of Sanguinarine in Promoting Apoptosis in Hepatocellular Carcinoma</p>
... To explore the possible mechanisms of SAN in HCC cells, bioinformatics methods were used. According to the BATMAN-TCM database (http://bionet.ncpsb.org/batman- tcm/), the number of predicted candidate target genes ...
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Expression and clinical significance of IGF-1, IGFBP-3, and IGFBP-7 in serum and lung cancer tissues from patients with non-small cell lung cancer
... and IGFBP-3, a hematoxylin and eosin staining kit, Mayer’s hematoxylin, and avidin-biotin complex stain were purchased from Wuhan Boster Biological Technology, Ltd (Wuhan, People’s Republic of ...An ...
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The low IGFBP 3 level is associated with esophageal cancer patients: a meta analysis
... low IGFBP-3 level and the risk, overall survival, and clinical pathological character- istics of esophageal ...of IGFBP-3 level were not exactly the same in the six in- cluded studies, and ...
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Comparative analysis of IGFBP 3 gene sequence in Egyptian sheep, cattle, and buffalo
... the IGFBP-3 ...cattle, 3 genotypes were identified; (AA), (AB), and ...of IGFBP-3 gene in sheep, cattle, buffalo, and goat was submitted to the NCBI GenBank (Accession ...in ...
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... on IGFBP-3 levels in rats under ”overtraining physical ...(C-Hib); 3) mild aerobic exercise (A-Ex); 4) overtraining exercise (OT); 5) overtraining exercise with ...cannula. IGFBP-3 was ...
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Changes in cerebrospinal fluid and blood plasma levels of IGF-II and its binding proteins in Alzheimer’s disease: an observational study
... In light of evidence linking the IGF-related system to cognition, as well as several changes observed in AD, we hypothesized that alterations in this system might con- tribute to the pathological mechanisms underlying ...
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Effects of Hibiscus sabdariffa Linn. on Malondialdehyde and Glutathione Peroxidase in an Overtraining Rat Model characterized by Growth Hormone, Insulin-like Growth Factor-1, and Insulin-like Growth Factor Binding Protein-3
... Blood sampling performed on day 3 post- treatment was done for measuring, GH, IGF-1, IGFBP-3, gene expression of IGFBP-3, MDA, and GPx. Rats were sacrificed with ether, then blood ...
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Detection and correlation analysis of serum cytokines in non-small-cell lung cancer patients with bone and non-bone metastases
... between IGFBP-3 and ...of IGFBP-3 and MCP-1 (r = ...IGF-1, IGFBP-3 could stimulate activation of MCP-1; however, this finding requires further experimental ...
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IGFBP-5 enhances epithelial cell adhesion and protects epithelial cells from TGFβ1-induced mesenchymal invasion
... how IGFBP-5 acts remains ...of IGFBP-5 which could not bind to IGFs (Allan et ...of IGFBP-5 are indeed IGF-independent. We found no evidence that IGFBP-5 could inhibit the actions of TGF  1 ...
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Journal of Applied Pharmaceutical Science
... IGF-1, a high potent mitogenic factor with a dual function is believed to participate with female steroids and other growth factors to prepare endometrium receptivity for successful embryo implantation and further ...
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Genetic variants in insulin-like growth factor binding protein-3 are associated with prostate cancer susceptibility in Eastern Chinese Han men
... Despite these strengths, our study still has some limita- tions. First, our study was conducted retrospectively, which carries an intrinsic bias. Second, our discovery stage study was performed using MassARRAY iPLEX ...
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Involvement of p53 in insulin-like growth factor binding protein-3 regulation in the breast cancer cell response to DNA damage
... Tissue culture plasticware was from Nunc (Roskilde, Denmark). Bovine serum albumin (BSA), epidermal growth factor (EGF), hydrocortisone and bovine insulin were from Sigma-Aldrich (St Louis, MO, USA). Cholera enterotoxin ...
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