IGRAS - INTERFERON GAMMA RELEASE ASSAYS
Interferon Gamma Release Assays (IGRAs) in the Diagnosis of Tuberculosis
... Centers for Disease Control and Prevention (CDC) 2010 Guidelines for Use of IGRA in Detection of LTBI. Both the standard qualitative test interpretation and the[r] ...
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Interferon Gamma Release Assays for Latent Tuberculosis: What Are the Sources of Variability?
... SUMMARY IGRAs are functional assays that are susceptible to variability from various sources. Different sources of variability have different ef- fects with the net sum of all sources resulting in either no ...
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Interferon-gamma release assays and childhood tuberculosis: systematic review and meta-analysis
... gradients (our gold standard comparison) rather than absolute exposure. Although studies used different selection methods and measure of exposure, we ana- lyzed studies collectively by defi ning study-specifi c gradients ...
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Interferon Gamma Release Assays for Diagnosis of Pleural Tuberculosis: a Systematic Review and Meta Analysis
... whole-blood assays, a similar threshold is not defined for pleural ...QuantiFERON assays. High back- ground pleural fluid interferon gamma levels in TPE patients may also contribute to ...
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Interferon gamma release assays based on M. tuberculosis- -specific antigens in sarcoidosis patients
... of IGRAs evaluated in patients with bacteriologically con- firmed tuberculosis ranged between 70−100%, with a pooled value of 94% for ...of IGRAs in tuberculosis patients was 80−81% depending on the ...of ...
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Role of interferon gamma release assays in the diagnosis of pulmonary tuberculosis in patients with advanced HIV infection
... affected by CD4+ T-lymphocyte count in our population with advanced immunosuppression. The test had mod- erate to high sensitivity but poor specificity in the diag- nosis of active pulmonary TB. In AFB smear-negative ...
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Comparison of two interferon gamma release assays in the diagnosis of Mycobacterium tuberculosis infection and disease in The Gambia
... the IGRAs may also be a considered a weakness of this study, as it makes any comparison of IGRA with the TST, subject to mis-classification ...the IGRAs with the TST but to evaluate the IGRAs in ...
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Interferon-gamma release assays for the tuberculosis serial testing of health care workers: a systematic review
... Hence, in view of the available data on the within- subject variability of the IFN- γ response and the use of IGRAs in the serial testing of HCWs in countries with low and intermediate incidences of TB, we ...
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Diagnosis of latent tuberculosis infection among HIV discordant partners using interferon gamma release assays
... Data analysis was performed using SAS 9.1 (SAS Inc, Cary, NC). Outcomes of interest included prevalence of LTBI, concordance between diagnostic tests, and risk fac- tors associated with a positive test result. ...
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Updated Guidelines for Using Interferon Gamma Release Assays to Detect Mycobacterium tuberculosis Infection United States, 2010
... During August 4–5, 2008, CDC convened a meeting in Atlanta, Georgia, to consider the use of QFT-GIT and T-Spot in U.S. tuberculosis-control activities. At this meeting, tabulated study results, descriptive summaries, ...
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Serial interferon gamma release assays for latent tuberculosis in dialysis patients with end stage renal disease in a Korean population
... Although previous studies have proposed that con- versions, reversions, and non-specific variations can occur with serial IGRA testing [17, 18], there are no studies about serial changes of IGRAs in patients with ...
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Poor agreement between interferon gamma release assays and the tuberculin skin test among HIV infected individuals in the country of Georgia
... of IGRAs, choosing test for LTBI, particularly in resource-limited settings, should ac- count for costs and ...of IGRAs among HIV infected patients, improved modalities are needed to accurately identify ...
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Systematic review and meta analysis on the utility of Interferon gamma release assays for the diagnosis of Mycobacterium tuberculosis finfection in children: a 2013 update
... both IGRAs seem to be a reasonable choice in the diagnosis of TB disease in immu- nocompetent children aged > 5 years in high income ...children IGRAs’ performance is equivalent or inferior to ...
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Latent tuberculosis infection and interferon-gamma release assays: what new knowledge did we gain through the Journal in 2009?
... advantages of the conventional TST are just partly overcome by the newer IGRAs, resulting in a gener- ally better sensitivity and specifi city. However, the re- sults of these tests should be interpreted with ...
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Short-Term Reproducibility of a Commercial Interferon Gamma Release Assay
... 2009 Interferon gamma release assays (IGRAs) have been shown to be sensitive and highly specific for the detection of immune memory against Mycobacterium ...continuous gamma ...
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Point Counterpoint: Should Interferon Gamma Release Assays Become the Standard Method for Screening Patients for Mycobacterium tuberculosis Infections in the United States?
... of IGRAs in routine clinical care are in populations with a high prevalence of BCG vaccination and patients at high risk for not returning for TST ...of IGRAs for detecting LTBI and active TB in our ...
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Reinhold, Lisa (2018): Reproduzierbarkeit quantitativer Messergebnisse bei Interferon-gamma-Release-Assays im Grenzbereich. Dissertation, LMU München: Medizinische Fakultät
... von IGRAS durch verschiedene Anwender bzw. die erneute Durchführung von IGRAs nach drei Tagen ergaben mit 0,82 und 1,00 hohe κ-Werte für die ...individuellen Interferon-γ-Mengen nach 3 Tagen, die von ...
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Comparing interferon gamma release assays with tuberculin skin test for identifying latent tuberculosis infection that progresses to active tuberculosis: systematic review and meta analysis
... with IGRAs/ ...of IGRAs in serial testing does not lead to a ‘booster ...using IGRAs to assess reproducibility can potentially lead to conversion/reversion of test results, and this can alter the ...
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Comparison of the QuantiFERON TB Gold Plus and QuantiFERON TB Gold In Tube Interferon Gamma Release Assays in Patients at Risk for Tuberculosis and in Health Care Workers
... QFT-Plus IGRAs across the spectrum of TB infection from low-risk or previously treated HCWs to immigrants from areas endemic for TB undergoing evaluation or follow-up for LTBI or active TB infection in a ...
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Comparing interferon-gamma release assays with tuberculin skin test for identifying latent tuberculosis infection that progresses to active tuberculosis : systematic review and meta-analysis
... of IGRAs), comparator (TST, cut-off values), Bacillus Calmette–Guérin (BCG) status, TB diagnosis, and out- comes (the proportion of people who progressed to ac- tive ...
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