IL-1
Exacerbation of CNS inflammation and neurodegeneration by systemic LPS treatment is independent of circulating IL 1 beta and IL 6
... cytokines IL-1 b and IL-6 by approximately 80 and 90% ...Both IL-1b and IL-6 have been strongly associated with the induction of fever responses in rodents in response to systemic LPS ...
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A crucial role for IL 1 in the induction of IL 17 producing T cells that mediate autoimmune encephalomyelitis
... of IL-23 and IL-1 in- volved amplifi cation of a TCR-activated pathway, we ex- amined the eff ects of IL-1 and IL-23 in the presence or absence of ...anti-CD3. ...
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Gene variants of interleukin-1 (il-1) and their role in development of osteoarthritis
... Osteoarthritis (OA) is the most frequent multifactorial joint disorder characterized by progressive loss of articular cartilage, joint inflammation (Swellam et al., 2010) and subchondral bone remodelling (Choi et al., ...
5
Human keratinocytes produce but do not process pro interleukin 1 (IL 1) beta Different strategies of IL 1 production and processing in monocytes and keratinocytes
... produce IL-1 alpha and beta mRNA in vitro, but only IL-1 alpha biological activity has been identified in keratinocyte ...of IL-1. Using several monoclonal antibodies to ...
7
Caspase-1 inhibitor ameliorates experimental autoimmune myasthenia gravis by innate dendric cell IL-1-IL-17 pathway
... and IL-18 can induce the secretion of IL-17 from many cells of the innate immune system, including γδ T cells and invariant natural killer T (iNKT) cells [7, ...Mature IL-1β binds first to the type ...
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Interleukin 1 (IL-1)- and IL-23-Mediated Expansion of Filarial Antigen-Specific Th17 and Th22 Cells in Filarial Lymphedema
... and IL-23 receptor blockade results in significantly de- creased frequencies of Th17 and Th22 cells in CP ...of IL-1, IL-23, TGF-, IL-10, and tumor necrosis factor (TNF) ...following ...
6
Transactivation by the p65 subunit of NF kappaB in response to interleukin 1 (IL 1) involves MyD88, IL 1 receptor associated kinase 1, TRAF 6, and Rac1
... MyD88, IL-1 receptor-associated kinase 1 (IRAK-1), and TRAF-6 drove p65-mediated ...the IL-1- induced response. In cells lacking MyD88 or IRAK-1, no effect of ...
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Urinary excretion of IL-1β, IL-6 and IL-8 cytokines during relapse and remission of idiopathic nephrotic syndrome
... The role of the immune factors in triggering a relapse of idio- pathic nephrotic syndrome has been a matter of debate during the past decade. The activation of T-cells leads to release of local cytokines that work as ...
5
Extracellular Neutrophil Proteases Are Efficient Regulators of IL 1, IL 33, and IL 36 Cytokine Activity but Poor Effectors of Microbial Killing
... Thus, IL-1 family cytokines behave as classical ‘‘danger signals,’’ released from their host cells upon cell-death-associated mem- brane ...of IL-1 family processing and activation, helping to ...
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IL 1 mediates TNF induced osteoclastogenesis
... lacking IL-1RI was approximately 50% that of their WT counterparts. Thus, IL-1 plays a central role in TNF targeting of stromal cells in the osteoclastogenic ...of IL-1Ra or ...
10
Characterization of CD44 induction by IL 1: a critical role for Egr 1
... by IL-1 on endothelial cells could also function to allow activation of endothelial ...that IL-1 is capable of inducing active CD44 given the reports on other cyto- kines (45, 48, ...
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Update on the management of systemic juvenile idiopathic arthritis and role of IL-1 and IL-6 inhibition
... and IL-6 inhibitors that have significantly improved ...arthritis, IL-1 inhibitors, IL-6 inhibitors, anakinra, tocilizumab, canakinumab, macrophage activation ...
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Distinct contribution of IL 6, TNF α, IL 1, and IL 10 to T cell–mediated spontaneous autoimmune arthritis in mice
... in IL-6 completely suppressed the development of arthritis in SKG mice, irrespective of the persistence of circulating rheumatoid ...Either IL-1 or TNF-a deficiency retarded the onset of arthritis ...
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Inflammasomes and IL 1 biology in the pathogenesis of allograft dysfunction
... the IL-1 receptor (IL-1R) pathway was markedly ...an IL-1R axis ...the IL-1 pathway in the perioperative lung transplant ...
9
Mass Spectrometric Analysis of the Endogenous Type I Interleukin 1 (IL 1) Receptor Signaling Complex Formed after IL 1 Binding Identifies IL 1RAcP, MyD88, and IRAK 4 as the Stable Components
... endogenous IL-1RI signaling complex using an analytical strategy based on im- munoprecipitation and tandem ...the IL-1RI signal- ing complex and the assessment of their possible phospho- ...were ...
9
IL 1 Receptor Type II Production Is Upregulated by IL 4 and IL 13, and Downregulated by IFN γ in Mouse Gingival Epithelial Cells
... and IL-1RII, respectively). The binding of IL-1 to IL-1RI induces cellular signaling and biological effects, whereas binding to IL-1RII does not induce cellular signaling and indirectly ...
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Serum IL-1β and IL-17 levels in patients with COPD: associations with clinical parameters
... pulmonary function (FEV 1 /FVC .70% and FEV 1 .80% of predicted) can be included as healthy control subjects. Exclusion criteria are listed as follows: asthma or atopy, a history of coronary heart disease ...
8
SERUM LEVEL OF IL 6, IL 1? AND TNF ? IN PATIENTS OF CHRONIC RENAL FAILURE WITH MAINTENANCE HAEMODIALYSIS
... and IL-6 and the degree of hypoalbuminemia and dyslipoproteinemia among HD ...plasma IL-6 levels were predictor of mortality among these ...of IL- 1, TNF-a, IL-6, and IL-13 among ...
13
The role of inflammasome derived IL 1 in driving IL 17 responses
... that IL-17 cells may also be involved [105, ...that IL-17A production by Th17 cells can act directly on airway smooth muscle to enhance allergen-induced airway hyper-responsive- ness ...of ...
9
Endogenous IL 1 in cognitive function and anxiety: a study in IL 1RI / mice
... in IL-1RI 2/2 mice appears the more likely ...of IL-1RI expression is associated with a decrease in anxiety is consistent with one previous study in IL-1RI 2/2 mice ...elevated IL-1b induces ...
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