IL-1 family
Divergent roles for the IL 1 family in gastrointestinal homeostasis and inflammation
... the IL-1 family which lacks an intracellular TIR domain and is thus incapable of initiating an intracellular signaling cascade ...by IL-1Ra with far lower affinity than IL-1RI and so ...
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The new IL 1 family member IL 1F8 stimulates production of inflammatory mediators by synovial fibroblasts and articular chondrocytes
... new IL-1 family members have not yet been well ...that IL-1F7 forms a complex with IL-18 binding protein, which might bind to and sequester IL-18R accessory protein, thus ...
11
Circulating levels of IL-1 family cytokines and receptors in Alzheimer’s disease: new markers of disease progression?
... Chicago, IL, ...for IL-1α, IL-1β, IL-1Ra, and IL-33 ...of IL-1 family cytokines and receptors and to evaluate the influence of several confounding variables (age, ...
12
Adipose and Liver Expression of Interleukin (IL)-1 Family Members in Morbid Obesity and Effects of Weight Loss
... of IL-1α, IL-1β, IL-18, IL-1Ra, IL-1F7 and NLRP3 were assessed by semi-quantita- tive real-time polymerase chain reaction (PCR) as described previously ...used: IL-1α, forward: ...
6
IL 1 family cytokines and soluble receptors in systemic lupus erythematosus
... cells, IL-33 orchestrates type 2 im- munity, also promoting the reparative capacity of macro- phages and ILCs and thus contributing to chronic fibrotic disorders [9, ...the IL-33/IL-1R4 axis has been ...
10
The role of novel IL 1 family members in Inflammatory Bowel Disease
... This demonstrates that lL-36 signaling in vivo is regulated by the orphan receptor SIGIRR and may suggest that enhanced responsiveness to IL-36 signaling may play a role in the increased[r] ...
176
The role of inflammasome derived IL 1 in driving IL 17 responses
... of IL-1 family cytokines ...of IL-1␣, IL-1, and IL-18 in response to LPS and other TLR ligands [69 ...limit IL-1 release. Autophagosomes can ...
9
Interleukin-1 Family Cytokines as Mucosal Vaccine Adjuvants for Induction of Protective Immunity against Influenza Virus
... with IL-1 family cytokines provided protection against influenza viral infection, with IL-1  and IL-18 providing com- plete ...of IL-1 family cytokines may ...
10
Signal transduction pathways activated by the IL 1 receptor family: ancient signaling machinery in mammals, insects, and plants
... the IL-1 family, IL-1a, IL-1b, and the IL-1 receptor antagonist ...of IL-1 are mediated by IL-1a and IL-1b with IL-1RA acting as a true ...
8
Cerebrospinal fluid markers of neuroinflammation in delirium: A role for interleukin 1ß in delirium after hip fracture
... CSF IL-1 β could be peripheral, since IL-1 β is capable of crossing from the periphery into the CNS via different routes [12 – 14], but given the lack of association between CSF and serum ...
7
Altered Interleukin-1 Receptor Antagonist and Interleukin-18 mRNA Expression in Myocardial Tissues of Patients with Dilatated Cardiomyopathy
... the IL-1/IL-1ra (IL-1 receptor antagonist) ratio influences these ...the IL-1 family and the related caspase-1 also contribute to regulation of ...
9
An investigation into the role of TMED1 in IL 33/ST2L singalling pathway
... If TMEDl does not interact with other IL-IR family members and moreover, is not involved in signalling pathways mediated by other IL-1 family ligands, this raises the possibility that TM[r] ...
227
Evolutionary divergence and functions of the human interleukin (IL) gene family
... The IL1-like genes have been grouped on the basis of sequence homology, genomic architecture and chromosomal location (Table 1). 47,48,51,67 They also share common signal transduction mechan- isms. 68 The ...
26
Il-10 Family Members as Novel Responders to Genotoxic Stress
... interleukin IL-10 family members, IL-19 and IL-24, that were upregulated with DNA ...damage. IL-19 was upregulated in response to ionizing radiation (IR) in multiple cell lines, ...
129
Divergence of IL 1, IL 18, and cell death in NLRP3 inflammasomopathies
... pro– IL-1β, and pro–IL-18 and a second stimulus, resulting in NLRP3 inflammasome formation ...either IL-1β or the IL-1 receptor (IL-1R) effectively resolve most CAPS symptoms and ...
12
Generation and characterization of ixekizumab, a humanized monoclonal antibody that neutralizes interleukin-17A
... for IL-17A for human, cynomolgus monkey, mouse, rat, and rabbit was determined with the surface plasmon resonance (SPR) using a Biacore biosensor 2000 (Biacore Life Sciences, Pittsburgh, PA, ...Mouse IL-17A ...
12
Cytokine Profiles in Malawian Children Presenting with Uncomplicated Malaria, Severe Malarial Anemia, and Cerebral Malaria
... Interestingly, there are some apparent paradoxes between the cytokine concentra- tions reported in this paper and the monocyte intracellular cytokine staining (42) and immunophenotyping (6) findings that we have reported ...
11
The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype
... that IL-17A may also act in sensi- 670 tised mice to dampen the allergic response by inhibiting chemo- 671 kine production, eosinophilia and bronchial hyperactivity 672 (Hellings et ...in IL-17 pro- 674 ...
14
Endogenous IL 1 in cognitive function and anxiety: a study in IL 1RI / mice
... the IL-1R1 2/2 mice [8] we therefore assessed these animals on the spatial discrimination/beacon version of the watermaze ...and IL-1R1 2/2 mice again showed an equivalent preference for the training ...
15
Effects of interleukin-1 on cardiac fibroblast function: Relevance to post-myocardial infarction remodelling
... CF, IL-1-induced MMP-3 expression was found to be p38-dependent whereas IL-1-induced MMP-9 expression was p38-independent (Turner et ...which IL-1-induced MMP-3 expression was ...
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