IL-1, interleukin-
The involvement of proinflammatory cytokines in diabetic nephropathy: Focus on interleukin 1 (IL-1), interleukin 6 (IL-6), and tumor necrosis factor-alpha (TNF-α) signaling mechanism
... Interleukin 1 is one of proinflammatory cytokines which predicted to be involved in inflamma- tion-based disease e.g. sepsis, autoimmune disease, including DN. The two main ligands are IL-1α and ...
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An Epstein-Barr Virus MicroRNA Blocks Interleukin-1 (IL-1) Signaling by Targeting IL-1 Receptor 1
... specifically interleukin-1  (IL-1  ...in interleukin signaling ...the IL-1 receptor 1 (IL1R1) as a direct target of ...disrupted IL-1  ...
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Mass Spectrometric Analysis of the Endogenous Type I Interleukin 1 (IL 1) Receptor Signaling Complex Formed after IL 1 Binding Identifies IL 1RAcP, MyD88, and IRAK 4 as the Stable Components
... I interleukin-1 (IL-1) receptor (IL-1RI) signaling complex using immunoprecipitation and tandem mass ...to interleukin-1 receptor-associated kinase ...of ...
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Gene variants of interleukin-1 (il-1) and their role in development of osteoarthritis
... as IL-1 that is primarily synthesized by chondrocyte cells (Loughlin et ...2002). IL-1 super family consist of three key classes of interrelated cytokines viz IL-1α, IL-1β, and ...
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T lymphocyte reactivity and antibody response to a synthetic peptide (glutamic acid alanine tyrosine) as a marker for disease resistance in chickens
... Accessory cell and interleukin-mediated interactions in an immune response leading to antibody production Ag, antigen; APC, antigen presenting cell; IL-1, interleukin 1; IL-2, interleuki[r] ...
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Interleukin 1 stimulates fibroblasts to produce granulocyte macrophage colony stimulating activity and prostaglandin E2
... monocyte-derived IL-1 and human recombinant IL-1 (10(-10) M) can be substituted for monocyte-conditioned medium in stimulating fibroblast GM-CSA and PGE2 ...of IL-1 stimulate ...
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Interleukin-1 associations in inflammatory bowel disease and the enteropathic seronegative spondylarthritis
... We studied three groups of patients, the CD, UC and pure arthritis (SpA) group. We subdivided IBD patients according to the presence of arthritis and finally all groups according to disease activity in order to identify ...
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Role of Interleukin 1 Alpha (IL 1α) and Interleukin 1 Receptor Antagonist (IL 1RA) in Pathogenesis of Juvenile Idiopathic Arthritis and Adult Onset Rheumatoid Arthritis of Iraqi Patients
... Such IL-1 family cytokine is produced locally in response to infection or inflammation by various tissues, and is observed with high levels in the circulation secondary to hepatic production as an ...
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Signal transduction pathways activated by the IL 1 receptor family: ancient signaling machinery in mammals, insects, and plants
... Abstract: Interleukin-1 (IL-1) is a central regula- tor of the immune and inflammatory ...of IL-1 receptors and IL-1 signal transduc- ...I IL-1 ...
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Differences in the Levels of Interleukin-1β (IL-1β) and Interleukin-1 Receptor Antagonist (IL-1ra) in Children with Status Epilepticus and Febrile Seizure
... that IL-1ra levels were ele- vated in all groups (reference value ...ever, IL-1ra levels in the febrile seizure group were sig- nificantly higher than in the status epilepticus ...of IL-1ra levels ...
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Increased Production of Proinflammatory Cytokines following Infection with Porcine Reproductive and Respiratory Syndrome Virus and Mycoplasma hyopneumoniae
... cytokines interleukin-1 (IL-1) ( ␣ and  ), IL-6, IL-8, IL-10, IL-12, and tumor necrosis factor alpha (TNF- ␣ ) in pulmonary alveolar macrophages (PAMs) was ...
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Immunomodulatory factors gene polymorphisms in chronic periodontitis: an overview
... whereas IL-1β act as an extracellular ...of IL-1α, IL-1β and also IL-1/IL-receptor antagonist (RA, anti in- flammatory cytokine) have been increased in patients with periodontal ...
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Anti-inflammatory properties of a novel peptide interleukin 1 receptor antagonist
... the IL-1-induced apoptosis of pancreatic islets and compared it to the potency of ...reduced IL-1-induced apoptosis by 93%, which was ...of IL-1-induced nitric oxide production, ...
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Distribution of interleukin-1 receptor complex at the synaptic membrane driven by interleukin-1β and NMDA stimulation
... that IL-1b is often over-produced in injured tissues in which there are high levels of glutamate [2-4], and this over-production has been related to the exacer- bation of glutamate-driven pathological conditions ...
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Immunotherapy of brain metastases: breaking a “dogma”
... factor-1; IL: Interleukin; IL-10: Interleukin-10; IL-1 β : Interleukin-1 β ; IL- 23: Interleukin-23; IL-6: Interleukin-6; ...
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IL 1ra delivered from poly(lactic co glycolic acid) microspheres attenuates IL 1β mediated degradation of nucleus pulposus in vitro
... that IL-1ra released from PLGA microspheres could inhibit the stimulatory effects of IL-1 b on tumor cell progression for at least 7 days ...released IL-1ra comprehensively inhib- ited the ...
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Poems Syndrome: A Review
... disability. 1, 2 The acronym POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes) captures several dominant features of the ...
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A phosphodiesterase 5 inhibitor, tadalafil, suppresses stromal predominance and inflammation in a rat model of nonbacterial prostatitis
... Phosphodiesterase type 5 inhibitors (PDE5-Is), such as tadalafil, are effective for the treatment of LUTS/BPH [5, 6], and have been acknowledged in the recent guidelines published by the Japanese Urological Association ...
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Simvastatin nanoparticles attenuated intestinal ischemia/reperfusion injury by downregulating BMP4/COX-2 pathway in rats
... and 1 h of ...of interleukin-4 (IL-4), interleukin-6 (IL-6), interleukin-10 (IL-10), tumor necrosis factor-α, and nitric oxide (NO) were checked, and the dry/wet intestine ...
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Vitamin D/VDR signaling inhibits LPS-induced IFNγ and IL-1β in Oral epithelia by regulating hypoxia-inducible factor-1α signaling pathway
... biological functions dependent on the vitamin D receptor (VDR), which is a member of nuclear hormone receptor superfamily and markedly expressed in a wide variety of cells [16]. While vitamin D/VDR signaling is known for ...
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