IL-10−/− mice
IL 13Rα2 and IL 10 coordinately suppress airway inflammation, airway hyperreactivity, and fibrosis in mice
... cern. IL-10 has been identified as a critical regulator of Th2 immunity, but mechanisms for controlling Th2 effector function remain ...unclear. IL-10 also has paradoxical effects on ...
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Collagen induced arthritis is exacerbated in IL 10 deficient mice
... recombinant IL-10 in CIA, in proteoglycan-induced arthri- tis, and in experimental autoimmune encephalomyelitis reduced disease severity, and neutralizing IL-10 with anti- bodies exacerbated ...
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Echinococcus granulosus infection reduces airway inflammation of mice likely through enhancing IL 10 and down regulation of IL 5 and IL 17A
... and IL-2), followed by a shift toward a Th2-type profile (IL-4, IL-5, IL-6, IL-10 and IL-13) in a mouse model ...protected mice from OVA-induced airway ...
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Altered cutaneous immune parameters in transgenic mice overexpressing viral IL 10 in the epidermis
... genic mice compared with WT mice after culture in ...30). IL-10 reduces the expression of costimulatory molecules by APCs, including macrophages and DCs (29, ...LCs, IL-10 ...
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Prevention of adoptively transferred diabetes in nonobese diabetic mice with IL 10 transduced islet specific Th1 lymphocytes A gene therapy model for autoimmune diabetes
... that IL-10 mRNA was detected af- ter 35 cycles of RT-PCR in isolated pancreatic islets of NOD mice over 5 wk old ...NOD mice, IL-10 and IFN-g mRNAs were detected with the semi- ...
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Parasitemia Induces High Plasma Levels of Interleukin-17 (IL-17) and Low Levels of Interleukin-10 (IL-10) and Transforming Growth Factor- (TGF-) in Pregnant Mice Infected with Malaria
... of IL- 10 increased during placental malaria when the parasites bound to Chondroitin sulphate Acid (CSA) in the placenta and thus caused an inflammatory ...and IL-1 beta), splenic production of TNF, ...
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Plasmodium berghei ANKA infection increases Foxp3, IL 10 and IL 2 in CXCL 10 deficient C57BL/6 mice
... that IL-10 levels increased in plasma during ...type mice. Interleukin-10 (IL- 10) is an anti-inflammatory cytokine and thus increased production during parasite infection was ...
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Distinct contribution of IL 6, TNF α, IL 1, and IL 10 to T cell–mediated spontaneous autoimmune arthritis in mice
... SKG mice, a new model of rheumatoid arthritis. Genetic deficiency in IL-6 completely suppressed the development of arthritis in SKG mice, irrespective of the persistence of circulating rheumatoid ...
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Virally Expressed Interleukin-10 Ameliorates Acute Encephalomyelitis and Chronic Demyelination in Coronavirus-Infected Mice
... infected IL-10 ⫺/⫺ mice until day 7 ...most mice (Fig. 8D). This decrease in IL-10 expression reflected virus clearance, because as in infected B6 mice, ...
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IL 10 is critical for Th2 responses in a murine model of allergic dermatitis
... (1). IL-10 has been reported to be a global suppressor of immune respons- es as well as an immunoregulator of the Th cell response ...that IL-10 can inhibit the production of proinflammatory ...
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Pancreatic islet production of murine interleukin 10 does not inhibit immune mediated tissue destruction
... murine IL-10 on in vivo immune ...transgenic mice expressing IL-10 in pancreatic beta cells (Ins-IL-10 mice) were grafted across the MHC barrier to examine if ...
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Repeated TLR9 stimulation results in macrophage activation syndrome–like disease in mice
... identified IL-10 as a negative regulator of the MAS-like pathology. Mice made hypore- sponsive to IL-10 developed a more severe phenotype, including the presence of large amounts of ...
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New developments in analysis of ocular surface diseases
... Secondly, IL-10 promotor polymorphisms A-2763C are associated with disease severity; those carrying the allele -2763A suffered from a poor clinical ...of IL-10 in vitro,27,10 displayed a poor ...
191
Mizoribine provides effective treatment of sequential histological change of arteritis and reduction of inflammatory cytokines and chemokines in an animal model of Kawasaki disease
... of mice autop- sied were measured by a Bio-Plex ...chemokines: IL-1a, IL- 1b, IL-2, IL-3, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p40, ...
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Interleukin-10 Deficiency Increases Atherosclerosis, Thrombosis, and Low-density Lipoproteins in Apolipoprotein E Knockout Mice
... between IL-10 and IL-12 may play a crucial role in the pathogenesis of atherosclerosis ...(22,23). IL-10, on the other hand, inhibits the secretion of MMPs (24), the synthesis of tissue ...
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Enhanced Inducible Costimulator Ligand (ICOS-L) Expression on Dendritic Cells in Interleukin-10 Deficiency and Its Impact on T-Cell Subsets in Respiratory Tract Infection
... Female IL-10 KO mice (IL-10 –/– ; C57BL/6-Il-10 tm1Cgn ) and ICOS KO mice (ICOS –/– , ...C57BL/6 mice were purchased from The Jackson Laboratory, Charles ...
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Investigating the immunomodulatory properties of hookworm excretory/secretory (ES) products
... as IL-4, IL-5, IL-10 from the antigen-specific restimulation of splenocytes of these mice, but also by the increased numbers of eosinophils and AAMacs recruited to the site of ...
224
Interleukin 10 inhibits antigen induced cellular recruitment into the airways of sensitized mice
... sensitized mice with 1 mg/mouse of a neutralizing anti-IL-10 mAb, which increased significantly ovalbumin-induced neutrophil and eosinophil accumulation in the BAL ...of IL-10, which, ...
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Interleukin 26 is overexpressed in human sepsis and contributes to inflammation, organ injury, and mortality in murine sepsis
... that IL-26 could en- hance inflammatory response in RA [17], inflammatory bowel disease (IBD) [7], or HCV infection ...that IL-26 was an important sepsis-related proinflammatory cytokine, which contrib- ...
PubMedCentral-PMC5004941.pdf
... intact IL-23R signaling pathway is associated with decreased production of IL-10 (12, 41), implying that IL-23R signaling sup- presses antiinflammatory ...that IL-10 levels in ...
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