IL-15
Viral Activation of Interleukin-15 (IL-15): Characterization of a Virus-Inducible Element in the IL-15 Promoter Region
... the IL-15 promoter region was mapped to be between positions ⫺295 and ⫺243 relative to the transcription start ...using IL-15 promoter-reporter mutation and deletion constructs in transfection ...
12
Transpresentation of interleukin‑15 by IL‑15/IL‑15Rα mRNA‑ engineered human dendritic cells boosts antitumoral natural killer cell activity
... Co‑electroporating IL‑15 and IL‑15Rα mRNA into DC, results on one hand in a high membrane expression and on the other hand in secretion of ...specifically, IL‑15 and the α‑moiety of the ...
11
The proinflammatory cytokines IL 2, IL 15 and IL 21 modulate the repertoire of mature human natural killer cell receptors
... gen AG, Basel, Switzerland), in accordance with the manufac- turer's instructions. One microgram of RNA was treated with DNase to eliminate any contaminating genomic DNA and sub- sequently reverse transcribed. The ...
15
Elevated levels of circulating IL 7 and IL 15 in patients with early stage prostate cancer
... However, IL-15 gene has also been found to be expressed by a multiplicity of other cell types, including stromal and epithelial ...express IL-15[34]. In our patients, IL serum titres ...
9
Original Article Serum levels of TNF-α, IL-1β, IL-9, and IL-15 in acute respiratory distress syndrome
... TNF-α IL-1β, IL-9, and IL-15 cytokines in the pathogenesis of acute respiratory distress syndrome ...TNF-α, IL-1β, IL-9, and IL-15 in both ...TNF-α, IL-1β, ...
8
Increase in IL-15 levels in patients with alopecia areata
... Duculan et al. performed a biopsy of the altered and unchanged scalp of 6 patients with AA before treatment and after topical methylprednisolone therapy to evaluate the activity of AA biomarkers. The qRT-PCR test before ...
8
Differential expression of pro inflammatory cytokines IL 15Ralpha, IL 15, IL 6 and TNFalpha in synovial fluid from Rheumatoid arthritis patients
... the IL-15 protein are found in the synovial fluid of early knee OA patients when com- pared to end-stage OA ...serum IL-15 levels are associated with severity of pain in patients with knee OA; ...
8
Synovial expression of IL 15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor
... The inter-individual variability in synovial staining was high for the cytokines IL-15, IL-1 α , IL-1ß, IFN- γ and TNF, shown in Table 1. The results of both the semi-quantitative analysis and ...
8
Resolution of psoriasis upon blockade of IL 15 biological activity in a xenograft mouse model
... of IL-15. This paper elegantly shows that formation of IL-15/IL-15R α complexes on cell surfaces enables transendosomal recycling of IL-15, leading to persistence of ...
11
Mechanisms involved in IL-15 superagonist enhancement of anti-PD-L1 therapy
... Cytokine therapy and immune checkpoint blockade are two major immunotherapy modalities in oncology. In the studies presented here, we combined the IL-15/ IL-15RαSushi-Fc superagonist N-803 with a ...
16
Continuous treatment with IL-15 exhausts human NK cells via a metabolic defect
... by IL-15 stimulation ...of IL-15 (20). A separate study showed that IL-15 activates mTOR, leading to prolonged antitumor NK cell capacity ...through IL-15 and did ...
15
Inflammatory IL 15 is required for optimal memory T cell responses
... Due to their ability to rapidly proliferate and produce effector cytokines, memory CD8 + T cells increase protection following reexposure to a pathogen. However, low inflammatory immunizations do not provide memory CD8 + ...
15
The contrasting roles of IL 2 and IL 15 in the life and death of lymphocytes: implications for the immunotherapy of rheumatological diseases
... the IL-2/IL-2R or IL-15/IL-15R systems have focused on the alpha subunit of the IL-2 ...toward IL-2Rα have met with considerable success in the treatment of leukemia and ...
7
Adjuvant IL 7 or IL 15 overcomes immunodominance and improves survival of the CD8+ memory cell pool
... 11, 15), IL-7–mediated cycling could broaden immune responses by enabling threshold-level TCR stimulation to cells already recruit- ed into the cell ...that IL-7 sig- naling (16) is critical for T ...
12
Effect of IL-7 and IL-15 on T cell phenotype in myelodysplastic syndromes
... microenvironment. IL-7 and IL-15, the members of common gamma-chain family cytokine, are essential for establishment of maintenance of normal immune system ...13], IL-15 plays an ...
10
IL 15, a survival factor for kidney epithelial cells, counteracts apoptosis and inflammation during nephritis
... importance, IL-15 and IL-2 are not expressed in the same ...of IL-2 in activated T cells, IL-15 is constitutive- ly expressed by a broad array of cell ...of IL-15. ...
11
Interleukin-15 in cancer immunotherapy: IL-15 receptor complex versus soluble IL-15 in a cancer cell-delivered murine leukemia model
... as IL-15 are vital with respect to activating immune cells, sustaining healthy immune functions, and augmenting the anti-tumor activity of effector cells, making them ideal candidates for cancer ...
13
IL-15 as a potential target in leukemia
... of IL-15 mRNA was also ...of IL-15R α , IL-15 mRNA and protein level was detected in HTLV-1-associated ...of IL-15R α . These findings suggest a role for IL-15R α in the ...
9
IL-27 enhances IL-15/IL-18-mediated activation of human natural killer cells
... (IL)-2, IL-15, and IL-21 or their combinations have been used to expand NK cells ...Traditionally, IL-2 has been exten- sively used to expand murine and human NK cells [19, ...20]. ...
12
Original Article Smooth muscle homeostasis in human atherosclerotic plaques through interleukin 15 signalling
... of IL- 15 on plaque SMC, and thusfar only Wuttge et al observed IL-15 positivity in SMC of experi- mental animals [3, ...the IL-15 staining patterns with the use of spectral ...
8