IL-21
IL 21 promotes the expansion of CD27+CD28+ tumor infiltrating lymphocytes with high cytotoxic potential and low collateral expansion of regulatory T cells
... high-dose IL-2, irradiated feeders and CD3 ligation via an anti-CD3 antibody (also called ...cytokines IL-2, IL-15, and IL-21 on the expansion and activation of TIL using this aAPC ...
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Chitosan nanoparticle-based delivery of fused NKG2D–IL-21 gene suppresses colon cancer growth in mice
... signal peptides was also added upstream the NKG2D gene. Liposome (Lipofectamine™ 2000) was obtained from Invitrogen (Grand Island, NY, USA). EndoFree Plasmid Maxi Kit from Qiagen (Düsseldorf, Germany) was further used to ...
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The proinflammatory cytokines IL 2, IL 15 and IL 21 modulate the repertoire of mature human natural killer cell receptors
... gen AG, Basel, Switzerland), in accordance with the manufac- turer's instructions. One microgram of RNA was treated with DNase to eliminate any contaminating genomic DNA and sub- sequently reverse transcribed. The ...
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Critical role of IL-21 and T follicular helper cells in hypertension and vascular dysfunction
... since IL-21 also has potent antitumor and antiviral ...fact, IL-21 is currently being investigated as a therapeutic agent in solid tumors and hematopoietic ...Boosting IL-21 ...
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Original Article Increased frequency of peripheral blood IL-21 follicular helper T cells and increased serum IL-21 levels in patients with non-traumatic osteonecrosis of the femoral head
... serum IL-21 levels were elevated in NONFH ...as IL-21, con- tribute to steroid-induced ONFH ...serum IL-21 levels mediate the development and progression of RA [16, ...17]. ...
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Natural allelic variation of the IL 21 receptor modulates ischemic stroke infarct volume
... of IL-21 in the transient MCAO model was shown to be predominantly from infiltrating T lymphocytes associated with reperfusion ...resident IL-21 and IL-21R, which are known to be ...
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IL-21 is required for CD4 memory formation in response to viral infection
... direct IL-21 signaling on CD4 T cells was also required for the formation of memory CD4 T cells in response to infection with vaccinia virus (VV) in ...of IL-21 ...direct IL-21 ...
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Increased serum concentrations of IL 1 beta, IL 21 and Th17 cells in overweight patients with rheumatoid arthritis
... serum IL-1β, IL-21 and Th17 cells in overweight patients with ...that IL-17-producing cells were markedly enriched in this population ...phenotypes. IL-1β, IL-21 and Th17 ...
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Overexpression of microRNA 155 increases IL 21 mediated STAT3 signaling and IL 21 production in systemic lupus erythematosus
... [22]. IL-21 signals almost exclusively through STAT phosphorylation, mainly STAT3 but also STAT1 and STAT5 ...as IL-21. In our study, we demonstrate that while IL-21 production ...
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Increase in IL 21 producing T cells in patients with systemic lupus erythematosus
... of IL- 21 in the pathogenesis of autoimmune diseases ...the IL-21 pathway by administration of a fusion protein (IL- ...of IL-21 in the inflamed colon of wild-type mice, ...
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The IL 21 receptor augments Th2 effector function and alternative macrophage activation
... to IL-21, they become much more sensi- tive to the Arg-1– and FIZZ1-inducing activities of IL-4 and ...confirming IL-21 as an important stimulus for the development of highly functional ...
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Interleukin-6 Receptor Blockade Selectively Reduces IL-21 Production by CD4 T Cells and IgG4 Autoantibodies in Rheumatoid Arthritis
... IL-21 is a major factor in the differentiation of human B cells into Ab-producing plasma cells ...that IL-6 also regulates Ab ...that IL-6 promotes the in vivo and in vitro production of IgG ...
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Interplay of Il-4, Il-21, and Ifnγ on Memory B Cell Fate Decisions
... cytokines—specifically IL-4, IL-21 and ...that IL-21 or IFNγ directly promote T-BET+ B cells in the context of TLR ...Further, IL-4 antagonizes IL-21-induced T-BET ...
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Observational study of Interleukin-21 (IL-21) does not distinguish Kawasaki disease from other causes of fever in children
... of IL-21 outside of the range of KD ...of IL-21 than the KD group and showed significant ...of IL-21 was seen in the category of suspected viral illness (p = ...
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Antigen-specific human NKT cells from tuberculosis patients produce IL-21 to help B cells for the production of immunoglobulins
... of IL-21 following BCG immunization in mice and humans ...and IL-13), and 17 (IL-17A, IL-21, and IL-23)-associated cytokines [28, ...
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Phosphorylation of IRF4 by ROCK2 regulates IL 17 and IL 21 production and the development of autoimmunity in mice
... of IL-17 and IL-21 ...both IL-17 and IL-21 only in the presence of specific inflammatory ...of IL-21 under Th17 skewing conditions, it did not exert any effects on ...
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Changes in Follicular Helper T Cells in Idiopathic Thrombocytopenic Purpura Patients
... and IL-6 could play subsidi- ary roles in the pathogenesis of ITP patients, which are in accordance with previous report ...by IL-6 and IL-21, c-Maf also induces CXCR5 expres- sion and ...
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Interleukin-21 Overexpression Dominates T Cell Response to Epstein-Barr Virus in a Fatal Case of X-Linked Lymphoproliferative Syndrome Type 1
... of IL-21-producing cells in XLP-1 disease ...generate IL-21-producing T cells and the compositions of the responding T cell populations in the IMN patient and ...produce IL-17A. (B) ...
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(5R) 5 Hydroxytriptolide (LLDT 8) inhibits osteoclastogenesis via RANKL/RANK/OPG signaling pathway
... [12]. IL-21 enhances osteoclas- togenesis in vitro by up-regulating the expression of RANKL in CD4 + T cells in CIA mice as well as CD4 + T cells and fibroblast-like FLS of RA patients ...Besides, ...
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A biologically active peptide mimetic of N acetylgalactosamine/galactose
... Findings: A 12-mer phage display library was screened with a GalNAc-specific lectin to identify an amino acid sequence that binds to the lectin. Phage particles that were eluted from the lectin with free GalNAc were ...
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