IL-23
The IL 23/IL 17 axis in inflammation
... (Th17/Th IL-17 ) that produce IL-17, IL-17F, IL-6, and TNF-a, but not IFN-g and ...blocking IL-23 or its downstream factors IL- 17 and IL-6, but not the ...
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Targeting IL-12/IL-23 by Employing a p40 Peptide-Based Vaccine Ameliorates TNBS-Induced Acute and Chronic Murine Colitis
... and IL-23 both share the p40 subunit and are key cytokines in the pathogenesis of Crohn’s ...p40, IL-12 and ...p40, IL-12, IL-23, IL-17, TNF, iNOS and Bcl-2 in colon ...
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Differential Interleukin-10 (IL-10) and IL-23 Production by Human Blood Monocytes and Dendritic Cells in Response to Commensal Enteric Bacteria
... 6 IL-10 controls the production of IL-12p70 and IL-23 by total PBMC and IL-12p40/70 by mDC in response to stimulation with commensal ...of IL-10 on the total response to ...
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Membrane bound IL 12 and IL 23 serve as potent mucosal adjuvants when co presented on whole inactivated influenza vaccines
... ulators IL-12 and IL-23 was fused inframe to the membrane anchoring regions of the hemagglutinin (HA) of A/WSN/33 influenza virus as previously described ...
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<p>Evaluating guselkumab: an anti-IL-23 antibody for the treatment of plaque psoriasis</p>
... Abstract: The approval of guselkumab marks the entry of the IL-23 inhibitor class into the therapeutic armamentarium for patients with moderate-to-severe plaque psoriasis. This class specifically targets ...
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IL 23/Th17 axis is not influenced by TNF blocking agents in ankylosing spondylitis patients
... higher IL-23R expres- sion on γ/δ T cells was also associated with increased IL-17 secretion ...and IL-23 production by activated macrophages and dendritic cells [1, ...of IL-23 ...
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Variations in IL-23 and IL-25 receptor gene structure, sequence and expression associated with the two disease forms of sheep paratuberculosis
... cytokines IL-12 and IL-23 with their respective receptor complexes, IL-12RB1/IL-12RB2 and IL-12RB1/ IL-23R ...of IL-12 and IL-23 [8, 19, 20] and ...
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ABT 874, a fully human monoclonal anti IL 12/IL 23 antibody for the potential treatment of autoimmune diseases
... the IL-12/23 pathway have been ...for IL-12 p40 and potently inhibits the biological activity of IL-12 and IL-23; it appears to be highly effective and is well tolerated in the ...
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CCR6 is required for IL 23–induced psoriasis like inflammation in mice
... for IL-22. We conclude that CCR6 is essential in a model of IL-23–induced, IL-22–mediated dermatitis, which develops in sequential T cell–independent and T cell–dependent ...in ...
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TLR2 ligation induces the production of IL 23/IL 17 via IL 6, STAT3 and NF kB pathway in patients with primary Sjogren's syndrome
... human IL-23, IL-17, and b-actin were amplified for IL-23 p19 by using the sense primer 5’-GCA GAT TCC AAG CCT CAG TC-3’ and the anti-sense primer 5’-TTC AAC ATA TGC AGG TCC CA-3’, for ...
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IL-23 secreted by myeloid cells drives castration-resistant prostate cancer.
... IL-23 has been reported to regulate the activation of STAT3/RORγ expression in naive CD4 T cells26–28; both STAT3 and RORγ can impact AR signaling in prostate cancer29,30. We therefore evaluated whether ...
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Regulation of the Th1 immune response : the role of IL-23 and the influence of genetic variations
... the IL-23R variants do not differ in receptor function, we retrovirally expressed the IL-23R in human T-cells and analyzed its functional ...of IL-23 mediated signaling in humans and thus ...
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Interleukin 1 (IL-1)- and IL-23-Mediated Expansion of Filarial Antigen-Specific Th17 and Th22 Cells in Filarial Lymphedema
... (IL-1), IL-23, and, to lesser extent, transforming growth factor  (TGF-), as blockade of any of these cytokines resulted in significantly diminished frequencies of Th17 and Th22 ...
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Original Article Therapeutic effect of α-lipoic acid on osteoarthritis patients and its influence on TLR4/NF-κB and IL-23/IL-17 signaling pathway
... of IL-17 and IL-23 in patients with osteoarthritis were signif- icantly higher than those of normal volunteers, and the degree of increase was corre- lated with the WOMAC func- tion score ...of ...
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Increased expression of CD25, CD83, and CD86, and secretion of IL 12, IL 23, and IL 10 by human dendritic cells incubated in the presence of Toll like receptor 2 ligands and Giardia duodenalis
... Cell-free supernatants of cell cultures were harvested after 48 h and stored at − 80°C until analysis by sandwich ELI- SAs for IL-12p40, IL-12p70, and IL-10 (all U-CyTech, Utrecht, The Netherlands), ...
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Differential Regulation of Interleukin-12 (IL-12)/IL-23 by Tim-3 Drives TH17 Cell Development during Hepatitis C Virus Infection
... of IL-12p35 expression and upregulation of IL- 23p19 expression in patients with chronic HCV ...intracellular IL-12p35 and IL- 23p19 production, in resting and TLR-stimulated monocytes de- ...
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Expression of il 23/th17 pathway in a murine model of coxsackie virus b3 induced viral myocarditis
... the IL-23/Th17 axis in VMC ...that IL-23 and IL-17 mRNA expression was elevated in VMC mice immediately after CVB3 incubation, and the Th17-specific transcription factor STAT3 was ...
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Unique CD14+ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL 23/IFN γ axis
... as IL-23, TNF-a, and IL-6, than typical intestinal resident macrophages (CD14 – CD33 + ...of IL-23 and TNF-a compared with those in normal controls or patients with ulcerative ...
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Anti–IL 23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis
... Anti–IL-23 therapy inhibits PLP epitope spreading and relapsing EAE. (A) Average clinical score of mice treated with anti–IL-23p19 (clone MB490) or anti-p40 antibody on the day of EAE onset. The ...
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Ectopic lymphoid neogenesis is strongly associated with activation of the IL 23 pathway in rheumatoid synovitis
... Alternatively, IL-23 could act on other cell types than canonical Th17 cells in the synovial ...pronounced IL-17A staining of mast cells and, to a lesser degree, neutrophils while ...
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