IL-23/IL-17 pathway
Interleukin-23 may contribute to the pathogenesis of lumbar disc herniation through the IL-23/IL-17 pathway
... that IL-17 was expressed in IVD tissues and its gene expression was much higher in the ruptured group than that in the non-ruptured group, which is consistent with the former ...of IL-1β, ...
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Therapeutic effect of the potent IL 12/IL 23 inhibitor STA 5326 on experimental autoimmune uveoretinitis
... that IL-12 p40 knockout and IL-23 p19 knockout mice are highly resistant to EAU and anti-IL-12 antibody treatment prevents EAU induction ...of IL-12 p40 were reduced in STA-5326-treated ...
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The IL 23/IL 17 axis in inflammation
... and IL-4. Two studies in this issue of the JCI demonstrate that blocking IL-23 or its downstream factors IL-17 and IL-6, but not the IL-12/ IFN-γ pathways, can ...
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Tissue specific CD4+ T cell priming determines the requirement for interleukin 23 in experimental arthritis
... heterodimeric IL-23 (p19/p40) is measured, very low levels are found despite high levels of the p19 subunit ...of IL- 23. An association of IL-23 levels in plasma with disease ...
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Studying the Serum as Well as Serous Level of IL-17 and IL-23 in Patients with Serous Otitis Media
... of IL-23 and IL-7 than their serum levels of the OME ...of IL-17 in patients compared to that in healthy ...that IL-23/IL-17 pathway has a remarkable ...
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IL 23 induces human osteoclastogenesis via IL 17 in vitro, and anti IL 23 antibody attenuates collagen induced arthritis in rats
... that IL-17 lev- els in synovial fluids are significantly higher in patients with RA than in patients with osteoarthritis and that IL-17 stimulates osteoclast differentiation by inducing the ...
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Evidence of IL 17, IP 10, and IL 10 involvement in multiple organ dysfunction and IL 17 pathway in acute renal failure associated to Plasmodium falciparum malaria
... In a previous study done in Gondia, an endemic malaria region in the state of Maharashtra in India, we identified two cytokine clusters that could differentiate CM from mild malaria (MM) using a two-way coupled ...
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TLR2 ligation induces the production of IL 23/IL 17 via IL 6, STAT3 and NF kB pathway in patients with primary Sjogren's syndrome
... only IL-17 but also IL-23, IL-6, IL-1b, and TNF-a, which are known to promote Th17 differentiation and amplifica- tion [19], were highly expressed in the salivary glands of ...
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IL 23 is essential for T cell–mediated colitis and promotes inflammation via IL 17 and IL 6
... models, IL-12 has been implicated as a major mediator of these diseases based on the ability of anti-p40 mAb treatment to reverse intestinal ...cytokine IL-23 shares the same p40 subunit with ...
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Th-17 regulatory cytokines inhibit corticosteroid induced airway structural cells apoptosis
... this pathway inhibited the profibrotic activity of these cells ...of IL- 21, IL-22, and IL-23 on fibroblasts suggest that these cy- tokines may play a critical role in regulating the ...
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The Transforming Growth Factor β1/Interleukin-31 Pathway Is Upregulated in Patients with Hepatitis B Virus-Related Acute-on-Chronic Liver Failure and Is Associated with Disease Severity and Survival
... to IL-31 promoters, before finally stimulating the production of IL-31 ...while IL-31 promotes inflammation responses ...signal pathway, which could further trigger the activity of downstream ...
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Original Article Therapeutic effect of α-lipoic acid on osteoarthritis patients and its influence on TLR4/NF-κB and IL-23/IL-17 signaling pathway
... of IL-17 and IL-23 in patients with osteoarthritis were signif- icantly higher than those of normal volunteers, and the degree of increase was corre- lated with the WOMAC func- tion score ...
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A crucial role for IL 1 in the induction of IL 17 producing T cells that mediate autoimmune encephalomyelitis
... of IL-23 and IL-1 in- volved amplifi cation of a TCR-activated pathway, we ex- amined the eff ects of IL-1 and IL-23 in the presence or absence of ...anti-CD3. ...
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Elevated IL 17 levels in semi immune anaemic mice infected with Plasmodium berghei ANKA
... high IL-17 levels alone is not enough to contribute in the high survival, but in association with high levels of IL-12, IL-4 and ...IFN-γ. IL-10 in the cur- rent study was similar in ...
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Regulation of pathogenic IL 17 responses in collagen induced arthritis: roles of endogenous interferon gamma and IL 4
... and IL-4, cytokines derived from Th1 and Th2 cells, respectively ...of IL-17 ...measure IL-17, one plausible inter- pretation of these results is that IFN-γ possibly takes on a pro- ...
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Variants in the IL17 pathway genes are associated with atopic asthma and atopy makers in a South American population
... The actions of IL-17A and IL-17F depend on the appropriate link to their receptors IL17RA and IL17RC [13]. It was showed that variants in IL17RC are associated with increased risk of asthma (rs11917994, ...
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Mucocutaneous candidiasis: the IL 17 pathway and implications for targeted immunotherapy
... Dectin-1 is a fungal pattern recognition receptor (PRR) that recognizes β-glucans, carbohydrates located in the cell wall of the yeast form of Candida (Figure 1). C-type lectin receptors (CLRs) such as Dectin-1 are ...
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IL-17 promoted the inhibition of medulloblastoma in mice by splenocyte injection
... of IL-17, IL-23 and RORC in tumor tissues and the serum con- centrations of IL-17 and IL-23 protein were increased in patients with medulloblastoma ...and ...
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The IL-23/IL-22/IL-18 axis in murine Campylobacter jejuni infection
... lacking IL-23p19, IL-22 or IL-18. Conventional wildtype (WT), IL-23p19 −/− , IL-22 −/− and IL-18 −/− mice were perorally infected with ...
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<p>Assessment of T helper 17-associated cytokines in thromboangiitis obliterans</p>
... both IL-17 and IL-23 signi fi cantly decreased in the patients with a chief com- plaint of gangrene, which might have been due to the omission of Th17 in the gangrenous ...
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