IL-33
Role of IL-33 in inflammation and disease
... for IL-33/ST2 in several rheumatological diseases, including rheumatoid arthritis (RA), osteoarthritis (OA), psoriatic arthritis (PsA) and systemic lupus erythematosus ...link IL-33 expression ...
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IL-1β mediates lung neutrophilia and IL-33 expression in a mouse model of viral-induced asthma exacerbation
... of IL-1β in rhinovirus-induced exacerbations is sup- ported by a chain of mechanisms involving pattern rec- ognition receptors ...of IL-1β by the inflammasome named nod-like receptor family pyrin domain ...
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The alarmin IL 33 promotes regulatory T cell function in the intestine
... CD3 (5 μg/ml) in RPMI (Invitrogen) containing 10% FCS, 2 mM l-glutamine, 0.05 mM 2- mercaptoethanol, and 100 U/ml each of penicillin and streptomycin (complete media). Antibodies and cytokines were added at the following ...
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A humanized mouse model to study asthmatic airway inflammation via the human IL-33/IL-13 axis
... administered IL-33 to hu–IL-3/GM/IL-5–triple Tg mice to investigate their utility as a model of eosinophilic inflamma- ...hyperplasia, IL-13 production, and AHR, were observed in ...
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Original Article IL-31, IL-33, and TSLP expression and relation to severity of asthma and rhinitis in Chinese allergic patients
... of IL-31R subunit and oncostatin M ...monocytes. IL-31 can activate JAK/STAT, MAPK, and PI3K/Akt signal- ing pathways by acting on its receptor, which plays an important role in the physiopathology of ...
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IL-33 deficiency causes persistent inflammation and severe neurodegeneration in retinal detachment
... Although IL-33 is considered as an alarmin when re- leased from damaged cells, it also has important immune regulatory ...glia-derived IL-33 is known to orchestrate tissue im- mune response ...
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IL 33–dependent induction of allergic lung inflammation by FcγRIII signaling
... ulate IL-33. Once the IL-33 is released, it can act on neighboring res- ident lung cells, including T cells and ILC2s, to drive development of allergic airway ...Additionally, ...
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Serum IL 33, a new marker predicting response to rituximab in rheumatoid arthritis
... serum IL-33 assessment needs the use of an accur- ate assay such as the Quantikine kit, but the relatively low frequency of patients with detectable IL-33 level ...qualitative IL- ...
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Molecular mechanisms of IL-33–mediated stromal interactions in cancer metastasis
... The IL-33-MMP9 axis in human cancer ...of IL-33- ST2-NF-κB-MMP9 signaling on cancer metastasis in mouse tumor models, we validated these findings in human cancer models to recapitulate the ...
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Extracellular Neutrophil Proteases Are Efficient Regulators of IL 1, IL 33, and IL 36 Cytokine Activity but Poor Effectors of Microbial Killing
... obscure. IL-1 family cytokines are important initiators of inflammation and are typi- cally released via necrosis but require proteolytic processing for ...six IL-1 family cytokines (IL-1a, ...
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IL-33 facilitates proliferation of colorectal cancer dependent on COX2/PGE2
... [1–3]. IL-33 mediates its biological effects mainly through specific receptor ST2, a member of Toll like receptor family [2, 4, ...5]. IL-33 combined with ST2 stimulates numerous signal ...
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Biliary repair and carcinogenesis are mediated by IL 33–dependent cholangiocyte proliferation
... Antibodies and reagents. Recombinant mouse and human IL-13 were from PeproTech; recombinant mouse and human IL-33 were from BioLegend. The following primary antibodies were used for flow cytometry: ...
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IL-25 and IL-33 induce Type 2 inflammation in basophils from subjects with allergic asthma
... with IL-33 could enhance basophil migration to- wards eotaxin [33], however no studies have thus far have shown an effect of IL-25 on basophil ...that IL-25 and IL-33 ...
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Exogenous IL-33 overcomes T cell tolerance in murine acute myeloid leukemia
... the IL-1 family cytokines that is mainly present in the nucleus of stromal cells, such as epithelial and endothelia cells ...[11]. IL-33 is secreted by passive release from necrotic cells to the ...
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Factors associated with plasma IL-33 levels in patients with chronic obstructive pulmonary disease
... median IL-33 level, eosinophil (%), and eosinophil (count) were ...of IL-33 (Figure 1). Among 307 patients, 126 (41%) patients showed IL-33 levels below the limits of ...of ...
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Phase 2a randomized, placebo-controlled study of anti–IL-33 in peanut allergy
... the IL-1 cytokine family and a ligand for the orphan IL-1 family receptor, suppression of tumorigenicity 2 (ST2), a membrane-bound receptor, which instigates the production of different types of cytokines ...
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IL-33 treatment attenuated diet-induced hepatic steatosis but aggravated hepatic fibrosis
... with IL-33 enhanced hepatic fibrosis in mice fed with ...fibrosis. IL-33 has been suggested to possess pro-fibrotic properties in skin and lung [32, ...33]. IL-33 ...
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THE CORRELATION BETWEEN SERUM TOTAL IGE AND IL 33 IN PATIENTS WITH ASTHMA AND ALLERGIC RHINITIS
... Serum IL-33 levels was astimated for 40 asthmatic (22 males, 18 females) and 35 allergic rhinitis patients (19 males, 16 females) compared with 15 healthy individuals controls, who attended the allergy ...
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Oxidative stress enhances the expression of IL-33 in human airway epithelial cells
... to IL-33 and glyceraldehyde-3-phos- phate dehydrogenase (GAPDH) using the 7500 Real- Time PCR System (Applied ...Biosystems): IL-33 (catalogue number Hs00369211_m1), GAPDH ...
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IL 33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system
... human IL-33 protein and polyclonal anti- rat IL-33 ...human IL-33 are BC081993 and AY905581, respectively. Rat or human IL-33 cDNA was subcloned into the expression ...
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