IL-4/13
IFN-γ, IL-4 and IL-13 modulate responsiveness of human airway smooth muscle cells to IL-13
... the IL- 13Rα1 and IL-4Rα ...of IL-13Rα2, as evidenced by both the relative receptor density and the fraction of cells bearing ...of IL-13Rα2 in human [42] and murine ASM cells upon ...
16
<p>IL-33/13 Axis and IL-4/31 Axis Play Distinct Roles in Inflammatory Process and Itch in Psoriasis and Atopic Dermatitis</p>
... of IL-31 were shown to be increased in AD lesions but not psoriatic plaques and the levels of IL-31 in AD lesions correlated with the expression of IL-13 and ...of IL-31 in primary ...
6
Interleukin (IL) 4 and IL 13 act on human lung fibroblasts Implication in asthma
... that IL-4 and IL-13 act on human lung fibroblasts by increasing the expression of cell surface b 1 integrin and VCAM-1 adhesion molecules and the secretion of some of the cytokines/chemokines ...
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Dynamics of IL-4 and IL-13 expression in the airways of sheep following allergen challenge
... at 4 °C with anti- bodies (Abs) to IL-4 (FITC-conjugated anti-bovine IL-4 mAb, 1:100; AbD Serotec, UK), or IL-13 (rabbit anti- bovine IL-13 polyclonal ...
11
Distinct signal transduction processes by IL-4 and IL-13 and influences from the Q551R variant of the human IL-4 receptor alpha chain
... the IL-4/IL-13 pathway have been reported, such as SOCS-1 (also known as SSI-1) [21]; however, this inhibitor was suggested to prevent acti- vation of STAT and, for example, act on Jak ...
11
Investigational therapeutics targeting the IL-4/IL-13/STAT-6 pathway for the treatment of asthma
... of IL-13 to the IL-13 type II receptor complex, signals are transduced mainly via JAKs to phosphor- ylate the tyrosine residues of signalling molecules, such as the STAT proteins [7, ...
9
The IL 4/IL 13/Stat6 signalling pathway promotes luminal mammary epithelial cell development
... and IL-4 (Il4), IL-13 (Il13) and Stat6 are important mediators of Th2 ...cytokines IL-12 (Il12), interferon gamma (INF ␥ ; also known as Ifng) and Tnf ␣ are downregulated concomitantly ...
12
<p>Dupilumab: Clinical Efficacy of Blocking IL-4/IL-13 Signalling in Chronic Rhinosinusitis with Nasal Polyps</p>
... immunity. IL-4 determines the CD4 + cell polarization to effector Th2 ...16 IL-4 is essential for immune cell survival both in healthy and Th2-driven in fl ammatory disease states, 17,18 ...
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IL 1 Receptor Type II Production Is Upregulated by IL 4 and IL 13, and Downregulated by IFN γ in Mouse Gingival Epithelial Cells
... multiple IL-4/IL-l3-inducible genes, including IL-1Ra [56], Fc epsilon receptor II [57], and IL-4 receptor ...[58]. IL-4 and IL-13 failed to induce ...
11
Secreted Respiratory Syncytial Virus G Glycoprotein Induces Interleukin-5 (IL-5), IL-13, and Eosinophilia by an IL-4-Independent Mechanism
... , IL-4, IL-5, IL-13, and eotaxin in lung ...IFN-␥, IL-4, and IL-5 in lung tissues of primed and challenged mice were measured with commercially available ...
11
Lack of association or interactions between the IL 4, IL 4Rα and IL 13 genes, and rheumatoid arthritis
... of IL-4 and IL-4R with both RA sus- ceptibility and severity [7,17,18], whereas the contribution of IL-13 variation has not previously been examined in ...the ...
7
High salt reduces the activation of IL 4– and IL 13–stimulated macrophages
... The effect of salt on immune cells may not necessarily be only pathogenic. Under physiological conditions, we postulate that the storage of sodium within the interstitial space primes effector immune cells, so when they ...
17
Structure and function of IL-4 and IL-13 receptors on human B cells
... CD40L. IL-13 is also active in antibody class switching. IL-4 was originally thought to be the only cytokine capable of switching B cells to the production of lgG4 and IgE, but ...
280
A study of b cell responses induced by IL-4 and IL-13
... between IL-4 dose responses for sIgM and CD23 ...afhnity IL-4 ...to IL-4 activity through the IL-4 and IL-13 ...because IL-4 dose ...
266
Dupilumab: a novel treatment for asthma
... and IL-13 in the pathophysiology of the most typical aspects of asthma, such as chronic airway inflammation, tissue remodeling, and bronchial hyperresponsiveness, these pleiotropic cytokines are now ...
8
Lymphomagenesis, hydronephrosis, and autoantibodies result from dysregulation of IL 9 and are differentially dependent on Th2 cytokines
... of IL-9 transgenic ...of IL-9 transgenic mice were an abnormal infiltrate of mast cells (Fig. 4, B, C, and ...another IL-9 transgenic line, but were not associated with hydronephrosis ...(Fig. ...
10
Oral administration of Clostridium butyricum CGMCC0313-1 inhibits β-lactoglobulin-induced intestinal anaphylaxis in a mouse model of food allergy
... including IL-4, IL-5, IL-13 ...release IL-17 which is connected with inflammation in the gut [38, ...of IL-10, TGF-β expressed by regDCs can directly mediate the ...
10
Oestrogen receptor negative breast cancers exhibit high cytokine content
... (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL- 10, IL-12 [p70], IL-13, IL-17, granulocyte colony-stimulating factor [G-CSF], ...
11
Soshiho tang water extract inhibits ovalbumin induced airway inflammation via the regulation of heme oxygenase 1
... including IL-4, IL-5, IL-13, IL-17, IL-33, and chemokine (eotaxin) into the BALF, IgE levels in plasma, inflammatory cell infiltration, mucus production, and HO-1 protein ...
10
A modular interface of IL-4 allows for scalable affinity without affecting specificity for the IL-4 receptor
... Human IL-4 was cloned into the expression vector pQE- 80L (Qiagen) modified to carry a gene encoding kanamy- cin resistance; human IL-13 was cloned into the expres- sion vector pET-28b ...
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