IL-6
IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6
... the IL-6/IL-6R or IL-6/sIL-6R complexes to gp130 leads to the transmission of the signal into the ...to IL-6 inde- pendent dimerization of gp130, activation and phos- ...
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An Autocrine IL-6/IGF-1R Loop Mediates EMT and Promotes Tumor Growth in Non-small Cell Lung Cancer
... by IL-6 decreased erlotinib sensitivity ...whether IL-6 could induce EMT in TKI-sensitive PC-9 ...that IL-6 promoted EMT, as presented by repression of E-cadherin and concomitant ...
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IL-6-mediated cross-talk between human preadipocytes and ductal carcinoma in situ in breast cancer progression
... primers. IL-6 and Interleukin 6 receptor (IL-6R) mRNA expression levels were measured in single culture and co-culture using the following primer sets (Add- itional file 1: Table ...
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Athletic humans and horses: Comparative analysis of interleukin-6 (IL-6) and IL-6 receptor (IL-6R) expression in peripheral blood mononuclear cells in trained and untrained subjects at rest
... via IL-6R, which exists both in a soluble (sIL-6R) and a membrane-bound ...of IL-6 with its soluble receptor, in fact, increases the half-life of IL-6 and allows signaling to occur in ...
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IL 6 involvement in epithelial cancers
... of IL-6 in can- cer and identify an EGFR/IL-6/STAT3 sig- naling cascade that is important for tumor- ...of IL-6) and EGFR mutations in lung tumors ...of IL-6, which ...
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Clinical significance of interleukin (IL)-6 in cancer metastasis to bone: potential of anti-IL-6 therapies
... The use of antibodies for therapeutically inhibiting cytokines such as IL-6 may soon be replaced by utilizing small protein, nonantibody-based inhibitors called avimers. Avimers may surpass monoclonal ...
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Original Article Expression of IL-2, IL-6, IL-10, and IL-1β in rats with fungal keratitis
... [7]. IL-1β is a kind of cytokine produced in the immune response of the body to infection, which can promote T cells to synthesize and secrete IL-2 during immune response, thus realizing tissue repair ...of ...
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Reciprocal activation between IL-6/STAT3 and NOX4/Akt signalings promotes proliferation and survival of non-small cell lung cancer cells
... on IL-6 expression, as well as JAK1/STAT3 activation in A549 cells, ...on IL-6 production ...NOX4-stimulated IL-6/STAT3 signaling in A549 ...enhances IL-6 ...
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Study on relationship between elderly sarcopenia and inflammatory cytokine IL-6, anti-inflammatory cytokine IL-10
... and IL-6 levels, IL-10 levels and IL-6/IL-10 ...and IL-6 levels, IL-10 levels and IL-6/IL-10 ...combinant IL-10 in humans has ...
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Differential expression of pro inflammatory cytokines IL 15Ralpha, IL 15, IL 6 and TNFalpha in synovial fluid from Rheumatoid arthritis patients
... TNFalpha, IL-6, e IL-15 in SF were measured in duplicate using commercially available ELISA kits purchased from R&D Systems according to the manufacturer’s instructions (Quantikine Human TNF ...
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Administration of Neutralizing Antibodies to Interleukin-6 (IL-6) Reduces Experimental Autoimmune Encephalomyelitis and Is Associated with Elevated Levels of IL-6 Bioactivity in Central Nervous System and Circulation
... We found increased levels of IL-6 bioactiv- ity in serum of animals treated with mAb to IL-6. In normal animals there was a slight increase in IL-6 levels, but levels were far more incre[r] ...
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In vitro secretion profiles of interleukin (IL)-1beta, IL-6, IL-8, IL-10, and TNF alpha after selective infection with Escherichia coli in human fetal membranes
... Conclusion: Selective stimulation of fetal membranes with Escherichia coli results in a differential production of IL-1beta, IL-6, TNFalpha, IL-8, and IL-10. These tissues were less ...
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IL 23 is essential for T cell–mediated colitis and promotes inflammation via IL 17 and IL 6
... Heightened IL-6 (19) and IL-17 levels (20) could be detected in both serum and intestinal tissue from patients with Crohn ...the IL-6 signaling pathway prevented the development of T ...
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HBV replication is significantly reduced by IL-6
... serum IL-6 has been reported to be elevated in patients with chronic hepatitis B, cirrhosis and hepatocellular carcinoma and represents the best marker of HBV-related clinical progression as compared with ...
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MAP4K4 and IL-6+ Th17 cells play important roles in non-obese type 2 diabetes
... levels of IL-6 but not of TNF-α [31]. Moreover, the MAP4K4 SNPs (rs2236936 and rs2236935) are associated with reduced insulin release only in lean subjects (BMI < 25). Consistently, the association of ...
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The effect of novel polymorphisms in the interleukin 6 (IL 6) gene on IL 6 transcription and plasma IL 6 levels, and an association with systemic onset juvenile chronic arthritis
... of IL-6, such as Castleman’s disease (13) and multiple mye- loma ...(14). IL-6 has been shown to mediate fever induced by IL-1 in animals (15) and to induce fever when administered to ...
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Serum soluble interleukin 6 (IL 6) receptor and IL 6/soluble IL 6 receptor complex in systemic juvenile rheumatoid arthritis
... human IL-6 receptor (sIL-6 R) levels were measured in the sera of 20 healthy children and of 25 patients with systemic juvenile rheumatoid arthritis ...serum IL-6 levels measured with ...
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Response to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor α to gp130 expression: fusing experimental insights and dynamic modelling
... disease-associated IL-6-induced signalling [54]. The humanized anti-IL-6Rα antibody Tocilizumab is approved to treat rheumatoid arthritis and juvenile idiopathic arth- ritis in more than 100 ...
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Interleukin 6 is autoregulated by transcriptional mechanisms in cultures of rat osteoblastic cells
... for IL-6 (NF-IL-6), alone or in combination ...rat IL-6 promoter (5 9 -AGGCGAGCTCAAAGAAAGA-3 9 ), in the presence of a 3 9 primer corresponding to bp 1 6 to 1 20 of the ...
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Interleukin 1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice
... of IL-1, IL-6, and TNF to the increased osteoclastogenesis induced by estrogen deficiency, ovariectomized (ovx) mice were treated with either IL-1 receptor antagonist (IL-1ra), a ...
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