IL-6/JAK2/STAT3
A novel anti-cancer agent Icaritin suppresses hepatocellular carcinoma initiation and malignant growth through the IL-6/ Jak2/Stat3 pathway
... of IL-6 receptors, gp80 and gp130 [39]. IL-6 binds to gp80 first and then recruits gp130 to signal downstream ...dimerization, Jak2 becomes activated and leads to tyrosine ...
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Icaritin suppresses multiple myeloma, by inhibiting IL-6/JAK2/ STAT3
... and JAK2/ STAT3/AKT signaling ...[16]. STAT3 is often constitutively activated in many human cancer cells such as multiple myeloma, leukemia, lymphoma, and solid tumors [16, 17], which confers ...
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The fiber metabolite butyrate reduces gp130 by targeting TRAF5 in colorectal cancer cells
... NaB reduces the gp130 protein level by increasing TRAF5 The association of TRAF5 could weaken the dimeriza- tion of gp130, resulting in gp130 dysfunction and inacti- vation of IL-6/JAK2/STAT3 ...
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<p>Cryptotanshinone inhibits esophageal squamous-cell carcinoma in vitro and in vivo through the suppression of STAT3 activation</p>
... on STAT3 activation, we stimulated esophageal carcinoma cells with IL-6 to detect the effect of CTS on the STAT3 signaling ...of IL-6 (25 ng/mL) for 30 minutes could effectively ...
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Epigallocatechin-3-gallate attenuates apoptosis and autophagy in concanavalin A-induced hepatitis by inhibiting BNIP3
... , IL-6, IFN- γ , and IL-1 β were purchased from R&D Systems (Minneapolis, MN, ..., IL-6, IFN- γ , IL-1 β , Bcl-2, Bax, Caspase-3, Caspase-9, Beclin-1, LC3I/II, LC3II, P62, ...
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Ilamycin C induces apoptosis and inhibits migration and invasion in triple-negative breast cancer by suppressing IL-6/STAT3 pathway
... , IL-6), and non-receptor tyro- sine kinases (Src and Janus kinase family proteins) [9– ...family, JAK2 can be activated by IL-6 and further recruits and phosphory- lates STAT3, ...
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Induction of metastatic potential by TrkB via activation of IL6/ JAK2/STAT3 and PI3K/AKT signaling in breast cancer
... the JAK2/STAT3 pathway, we assessed IL-6-induced JAK2 and STAT3 activation in MBA-MB-231 and Hs578T control-shRNA or TrkB-shRNA ...of JAK2/STAT3, as well as Twist-1 ...
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The Influence of Gastrodin on Expression of IL 10, STAT3 and JAK2 in Epileptic Rats’ Hippocampus
... of JAK2/STAT3 target, our experimental results show that the JAK2 and STAT3 expression in EP Group is significantly higher than that in NC group, and the JAK2 and STAT3 positive ...
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LPS induced release of IL 6 from glia modulates production of IL 1? in a JAK2 dependent manner
... phosphorylated JAK2 with TNFR1. A similar association between JAK2 and the receptor has been reported in HEK293, H1299 lung adenocarcinoma and MCF7 human breast carcin- oma cells ...activated JAK2 ...
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Adenovirus-mediated delivery of bFGF small interfering RNA reduces STAT3 phosphorylation and induces the depolarization of mitochondria and apoptosis in glioma cells U251
... of STAT3 inactivation, the activation of the JAK2-STAT3 pathway was ...or IL-6 family cytokines, JAK2 proteins bind receptors and trans- or auto-phosphory- late themselves as ...
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LPS-induced release of IL-6 from glia modulates production of IL-1β in a JAK2-dependent manner
... phosphorylated JAK2 with TNFR1. A similar association between JAK2 and the receptor has been reported in HEK293, H1299 lung adenocarcinoma and MCF7 human breast carcin- oma cells ...activated JAK2 ...
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An Autocrine IL-6/IGF-1R Loop Mediates EMT and Promotes Tumor Growth in Non-small Cell Lung Cancer
... Technologies), STAT3 (Cell Signaling Technologies), phospho-STAT3 (Cell Signaling Technologies), phospho-IGF-I (Cell Signaling Technologies, Danvers, MA, USA), JAK1, phospho-Jak1 (Tyr1022/1023) (Cell ...
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The JAK2 pathway is activated in idiopathic pulmonary fibrosis
... or IL-6 (50 ng/mL; Sigma) together with IL-13 (50 ng/mL; Sigma) for the indicated times, replacing the culture medium and stimulus every 24 ...ng/mL), IL-6 (50 ng/mL), and IL-13 ...
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Mechanisms of SOCS3 phosphorylation upon interleukin 6 stimulation: Contributions of Src and receptor tyrosine kinases
... of JAK2-JH1, whereas the inactive mutant JAK2-JH1FF is not able to induce SOCS3 phosphorylation (lanes 1 and ...or JAK2-JH1, ...upon IL-6 Stimulation Can Be Blocked by the Src Kinase ...
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Associations of potentially functional variants in IL-6 JAKs and STAT3 with gastric cancer risk in an eastern Chinese population
... JAK1, JAK2, and STAT3 are considered the essential components of the IL-6/JAK/STAT3 signaling pathway involved in promoting tumorigenesis [11], and these genes were observed to be ...
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Original Article IL-9 promotes proliferation and metastasis of hepatocellular cancer cells by activating JAK2/STAT3 pathway
... JAKs, STAT3 translocate to nucleus and induce expression of down- stream molecules, such as vascular endotheli- al growth factor (VEGF), matrix metalloprotein- ase (MMP)-2, and MMP-9 [6], which are ...
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<p>Bit1 Silencing Enhances the Proliferation, Migration, and Invasion of Glioma Cells Through Activation of the IL-6/STAT3 Pathway</p>
... the IL-6/STAT3 signaling pathway plays a crucial role in ...the IL-6/STAT3 signaling pathway in gliomas, but also its role in their biological processes as well as the under- ...
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Reciprocal activation between IL-6/STAT3 and NOX4/Akt signalings promotes proliferation and survival of non-small cell lung cancer cells
... of IL-6 in exhaled breath condensate (EBC) and in serum were confirmed to be related to tumor size in patients with NSCLC ...Circulating IL-6 level is also a prognostic marker for survival in ...
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The JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance
... of JAK2 was significantly increased after RT in all tested CRC cells, including patient-derived primary CRC cells and human CRC cell lines, while the in- crease in ATM transcription was statistically significant ...
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Prostate-specific IL-6 transgene autonomously induce prostate neoplasm through amplifying inflammation in the prostate and peri-prostatic adipose tissue
... of IL-6 in prostate cancer pro- gression is well established, whether IL-6 plays a causative role in prostate cancer risk and early development is not clearly well ...of IL-6 ...
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