IL-6/STAT3
<p>Bit1 Silencing Enhances the Proliferation, Migration, and Invasion of Glioma Cells Through Activation of the IL-6/STAT3 Pathway</p>
... an IL-6 regulated pathway. IL-6 induces STAT3 activation and phos- phorylation through its receptor ...vated STAT3 then inhibits cancer cells apoptosis by regulating the ...
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Original Article IL-6/STAT3 signaling pathway is activated in plasma cell mastitis
... (for IL-6 and Bcl-2 staining) or 1 mmol/L Tris/EDTA buffer (PH ...with IL-6 polyclonal antibody (1:500, Abcam, Cambridge, UK), phos- pho-STAT3-Tyr705 rabbit monoclonal antibody (1:200, ...
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Icaritin suppresses multiple myeloma, by inhibiting IL-6/JAK2/ STAT3
... Activated STAT3 promotes tumorigenesis by blocking apoptosis and enhancing proliferation and angiogenesis, and increases cell multidrug-resistance [33, ...inhibited IL-6/STAT3 activities, ...
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Reciprocal activation between IL-6/STAT3 and NOX4/Akt signalings promotes proliferation and survival of non-small cell lung cancer cells
... on IL-6 expression in NSCLC cells was first evaluated in A549 cells stably expressing ectopic ...promoted IL-6 production in A549 cells assayed by ...to STAT3 activation and mediates ...
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Original Article Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium
... of IL-6 and STAT3 in cholesteatoma epithelium [6, ...between IL-6 and p-STAT3 expression, namely, obvi- ously increased p-STAT3 expression existed in cholesteatoma ...
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Original Article N-myc downstream-regulated gene 2 is related to insulin resistance through IL-6/STAT3 pathways in type 2 diabetic mice
... related IL-6/STAT3 ...and IL-6 levels of the two groups were ...Ndrg2, IL-6, STAT3, and p-STAT3 in pancreatic tissues were also identified by ...
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The inflammatory/cancer-related IL-6/STAT3/NF-κB positive feedback loop includes AUF1 and maintains the active state of breast myofibroblasts
... that STAT3 is phosphorylated, IL-6 as well as the NF-kB sub-units (p50 and p65) are up-regulated, while PTEN is repressed in most CAFs as compared to their counterparts ...TCFs. IL-6 is ...
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Inflammation, cytokines, the IL-17/IL-6/STAT3/NF-κB axis, and tumorigenesis
... secrete IL-17A, IL-17F, IL-21, and IL-22 to fight extracellular bacteria and fungi by stimulating epithelial cells to produce chemokines and cytokines, which drive the immune ...secrete ...
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TLR2 ligation induces the production of IL 23/IL 17 via IL 6, STAT3 and NF kB pathway in patients with primary Sjogren's syndrome
... and IL-1b (Santa Cruz Biotechnology, Inc., Santa Cruz, CA, USA) and IL- 17, IL-23, and TNF- a (R&D Systems, ...and IL-6 (Abcam, Cambridge, ...
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Ribonucleic acid interference knockdown of IL-6 enhances the efficacy of cisplatin in laryngeal cancer stem cells by down-regulating the IL-6/STAT3/HIF1 pathway
... of IL-6, as achieved using a siRNA technique, can increase the chemo- drug efficacy of cisplatin in laryngeal ...that IL-6 knockdown can increase chemo-drug efficacy, reduce drug resistance, ...
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The Akt1/IL-6/STAT3 pathway regulates growth of lung tumor initiating cells
... regulates IL-6 production in NSCLC cells by inducing IkB degradation, which allows NF-kB to enter the nucleus and activate IL-6 transcription [61, 62] and, on the other hand, that a critical ...
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IRE1α XBP1 pathway promotes melanoma progression by regulating IL 6/STAT3 signaling
... upregulated IL-6 induced by the activation of the IRE1α-XBP1 branch, we evaluated the phosphorylation levels of STAT3 in Mel-RMu cells with IRE1α or XBP1s ...in STAT3 phosphorylation was ...
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Quercetin inhibits epithelial–mesenchymal transition, decreases invasiveness and metastasis, and reverses IL-6 induced epithelial–mesenchymal transition, expression of MMP by inhibiting STAT3 signaling in pancreatic cancer cells
... the IL-6-induced increase in malignancy via inhibition of the STAT3 signaling ...that IL-6 can induce EMT and the secretion of MMPs. IL-6-induced EMT and the secre- tion ...
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Associations of potentially functional variants in IL-6 JAKs and STAT3 with gastric cancer risk in an eastern Chinese population
... In the present study, we also found that the JAK1 rs2230587 SNP was associated with an increased GC risk in a dominant model, and elevated mRNA expression levels of the gene were also associated with the A variant ...
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miR 146a modulates autoreactive Th17 cell differentiation and regulates organ specific autoimmunity
... autocrine IL-6 and ...autocrine IL-6 and IL-21 in mod- ulating Th17 polarization of miR-146a–deficient autoreactive CD4 T cells, we stimulated 2D2 and 2D2-KO T cells in vitro and ana- ...
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The fiber metabolite butyrate reduces gp130 by targeting TRAF5 in colorectal cancer cells
... JAK2/ STAT3 signaling was not naturally activated in vitro because there no cytokine was detected in the RPMI- 1640 ...Thus, IL-6 was added to activate JAK2/ STAT3 ...and STAT3. The ...
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Blocking interleukin-6 trans-signaling protects against renal fibrosis by suppressing STAT3 activation
... 1A), IL-6 and sIL-6R in plasma (Supplementary Figure S1A-B) were significantly increased on day 14 after UUO as compared with levels in those receiving sham ...in IL-6, sIL-6R, mIL-6R, and ...
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Avian leukosis virus subgroup J induces VEGF expression via NF-κB/PI3K-dependent IL-6 production
... the STAT3 pathway was activated upon IL-6-induced VEGF-A and VEGFR-2 expression, VECs were transfected with the IL-6 gene expression vector or control vector for 48 ...
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Docosahexaenoic acid-containing choline phospholipid modulates LPS-induced neuroinflammation in vivo and in microglia in vitro
... LPS-induced IL-1β, IL-6, and TNFα through its effect on LPS receptors and signaling path- way ...on IL-6 receptors and STAT3 phosphorylation, which is a hallmark of ...
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An Autocrine IL-6/IGF-1R Loop Mediates EMT and Promotes Tumor Growth in Non-small Cell Lung Cancer
... used IL-6 to induce EMT in EGFR-TKI sensitive NSCLC ...both STAT3 and IGF-1R were activated. Interestingly activation of STAT3 and JAK1 was blocked by inhibiting IGF-1R, suggesting that IGF-1R ...
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