IL-6/STAT3 pathway
Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats
... hepatotoxicity, IL-6 acts on hepatocytes to stimulate liver regeneration and ...Secreted IL-6 binds to its receptor through the gp130 receptor, activating ...kinases pathway, which is ...
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The Akt1/IL-6/STAT3 pathway regulates growth of lung tumor initiating cells
... signalling pathway regulates generation and stem cell-like properties of Non-Small Cell Lung Cancer (NSCLC) tumor initiating cells ...identified IL-6 as a critical target of Akt signalling in NSCLC ...
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<p>Cinobufagin Suppresses The Characteristics Of Osteosarcoma Cancer Cells By Inhibiting The IL-6-OPN-STAT3 Pathway</p>
... Generally, IL-6 is known to modulate the self-renewal of stem cells by phosphorylating the STAT3, MAPK and Akt signaling ...and IL-6-inducible activation of STAT3 (Tyr705) and ...
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<p>Bit1 Silencing Enhances the Proliferation, Migration, and Invasion of Glioma Cells Through Activation of the IL-6/STAT3 Pathway</p>
... Corylifol A, a member of the iso fl avone subclass, has been shown to possess speci fi c inhibitory effects on IL-6-induced activation and phosphorylation of STAT3, thereby blocking the ...
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The IL 6–gp130–STAT3 pathway in hepatocytes triggers liver protection in T cell–mediated liver injury
... The IL-6–triggered molecular mechanisms leading to liver protec- tion are not completely ...transduction, IL-6 binds the membrane-bound IL-6 receptor α ...The ...
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Original Article IL-6/STAT3 signaling pathway is activated in plasma cell mastitis
... IL-6/STAT3 pathway rescues T cells and plasma cells from apoptosis, and promotes chronic inflammatory cells infiltration [30, ...that IL-6/STAT3 pathway may inhibit ...
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IL-6 and IL-8 secreted by tumour cells impair the function of NK cells via the STAT3 pathway in oesophageal squamous cell carcinoma
... drive IL-5 and IL-13 production in cultured NK cells and to limit cytotoxic responses ...after IL-6 or IL-8 stimulation. Additionally, the addition of IL-6 or IL-8 ...
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Prostate-specific IL-6 transgene autonomously induce prostate neoplasm through amplifying inflammation in the prostate and peri-prostatic adipose tissue
... of IL-6 in prostate cancer pro- gression is well established, whether IL-6 plays a causative role in prostate cancer risk and early development is not clearly well ...of IL-6 ...
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Original Article Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium
... the STAT3 expression in cholesteatoma has been carried ...of STAT3 in cholesteatoma tis- sues and EAC skin, and discovered an obvious- ly increased expression of p-STAT3 in choleste- atoma tissues as ...
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Associations of potentially functional variants in IL-6 JAKs and STAT3 with gastric cancer risk in an eastern Chinese population
... the IL-6/JAK/ STAT3 pathway and GCa risk with a relatively large sample ...the pathway and may have missed some important, truly functional ...the IL-6/JAK/STAT3 ...
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Avian leukosis virus subgroup J induces VEGF expression via NF-κB/PI3K-dependent IL-6 production
... the STAT3 pathway was activated upon IL-6-induced VEGF-A and VEGFR-2 expression, VECs were transfected with the IL-6 gene expression vector or control vector for 48 ...
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Effects of IL-6 and AG490 on regulation of Stat3 signaling pathway and invasion of human pancreatic cancer cells in vitro
... Cell viability was determined by 3-(4,5-dimethylthiazole- 2-yl)-2.5-diphenyltetrazolium bromide (MTT) assay. Pancreatic cancer cells were seeded in 96-well culture plates in culture medium. After 24 hours, the medium was ...
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TLR2 ligation induces the production of IL 23/IL 17 via IL 6, STAT3 and NF kB pathway in patients with primary Sjogren's syndrome
... human IL-23, IL-17, and b-actin were amplified for IL-23 p19 by using the sense primer 5’-GCA GAT TCC AAG CCT CAG TC-3’ and the anti-sense primer 5’-TTC AAC ATA TGC AGG TCC CA-3’, for IL-17 by ...
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Reciprocal activation between IL-6/STAT3 and NOX4/Akt signalings promotes proliferation and survival of non-small cell lung cancer cells
... ROS/PI3K/Akt pathway is the well-documented downstream signaling of NOX ...on IL-6 expression, as well as JAK1/STAT3 activation in A549 cells, ...PI3K/Akt pathway inhibitors, LY294002 ...
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Mechanisms of tumor necrosis factor-α-induced interleukin-6 synthesis in glioma cells
... B pathway, the main intra- cellular signaling pathway activated by cytokines is the Janus family of tyrosine kinase (JAK)-signal transducer and activator of transcription (STAT) ...JAK-STAT pathway ...
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Ribonucleic acid interference knockdown of IL-6 enhances the efficacy of cisplatin in laryngeal cancer stem cells by down-regulating the IL-6/STAT3/HIF1 pathway
... The findings that HIF1 is increased in laryngeal CSC may indicate another factor that contributes to drug- resistance in CSC. HIF1 is comprised of α subunit which is oxygen-dependent and β subunit which is continu- ally ...
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IRE1α XBP1 pathway promotes melanoma progression by regulating IL 6/STAT3 signaling
... upregulated IL-6 induced by the activation of the IRE1α-XBP1 branch, we evaluated the phosphorylation levels of STAT3 in Mel-RMu cells with IRE1α or XBP1s ...in STAT3 phosphorylation was ...
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Original Article Downregulation of HSF2 inhibits inflammation in human intestinal epithelial cells by regulating IL-6/STAT3 signaling pathway
... (IL-1), IL-6 and IL-10 levels were analyzed by ...and STAT3 signaling pathway-associated mol- ecules were detected by Western ...inhibited, IL-1 and IL-6 ...
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Acquisition of resistance to trastuzumab in gastric cancer cells is associated with activation of IL-6/STAT3/Jagged-1/Notch positive feedback loop
... 49]. IL-6 is also capable of expanding CSCs and inducing EMT ...identified IL-6 as a target of Notch in breast cancer ...the IL-6 transcription via interaction with the ...
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Icaritin suppresses multiple myeloma, by inhibiting IL-6/JAK2/ STAT3
... signaling pathway, not associated with estrogen ...with STAT3-directed siRNA and non-specific siRNA (control), the success of STAT3 silencing was confirmed by western ...with STAT3 siRNA or ...
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