Imiquimod-induced
Caspase 11 Mediated Cell Death Contributes to the Pathogenesis of Imiquimod Induced Psoriasis
... Please cite this article as: Kenealy S, Manils J, Raverdeau M, Munoz-Wolf N, Barber G, Liddicoat A, Lavelle EC, Creagh EM, Caspase-11 Mediated Cell Death Contributes to the Pathogenesis of Imiquimod-Induced ...
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The human papillomavirus (HPV) E7 protein antagonises an Imiquimod-induced inflammatory pathway in primary human keratinocytes
... for imiquimod, TLR7, and as such are stimulated by imiquimod through a novel ...of imiquimod induced cytokine production required residues in the CR1 and CR3 regions of E7 and resulted in ...
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Original Article Suppressive effect of β, β-dimethylacryloyl alkannin on activated dendritic cells in an imiquimod-induced psoriasis mouse model
... Abstract: Purpose: To investigate the effect of β, β-dimethylacryloyl alkannin, a main component of Lithospermum erythrorhizon, on activated dendritic cells (DCs) in a psoriasis mouse model. Methods: BALB/c mice were ...
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Anti inflammatory effects of a methanol extract of Dictamnus dasycarpus Turcz root bark on imiquimod induced psoriasis
... MEDD effects on STAT1 and STAT3 in IMQ-induced psoriasis STAT1 and STAT3 are the major factors that stimulate helper T cells to produce IFNγ and IL-17, respectively [26]. The levels of these STAT proteins were ...
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Comprehensive, Multimodal Characterization of an Imiquimod-Induced Human Skin Inflammation Model for Drug Development
... Figure 1 (a) Treatment schedule of the study. Treatment areas 1 and 2 served as biopsy sites for biopsies after 1 (24 hours) and 2 (48 hours) days of treatment. Treatment sites 3 and 4 served as sites for all erythema ...
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Epigallocatechin 3 gallate (EGCG) inhibits imiquimod induced psoriasis like inflammation of BALB/c mice
... Numerous studies have demonstrated that EGCG has anti-inflammatory, anti-carcinogenic, antioxidant, anti- aging and anti-mutagenic effects [17, 29]. Stephen Hsu et al. found that the symptoms of flaky skin in mice were ...
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Chitosan-based nanoformulated (–)-epigallocatechin-3-gallate (EGCG) modulates human keratinocyte-induced responses and alleviates imiquimod-induced murine psoriasiform dermatitis
... Background: Psoriasis is a chronic and currently incurable inflammatory skin disease characterized by hyperproliferation, aberrant differentiation, and inflammation, leading to disrupted skin barrier function. The use of ...
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Original Article Matrine alleviates imiquimod-induced psoriasiform dermatitis in BALB/c mice via dendritic cell regulation
... Research on Sophora flavescens (Ku shen) has increased in recent years. Sophora flavescens, a well-known, traditional Chinese medicine, is extensively used for treating various inflamma- tory disorders, such as eczema, ...
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Original Article Pilose antler extracts protect against imiquimod-induced psoriasis-like inflammation
... Abstract: Psoriasis is a chronic inflammatory skin disease characterized by excessive proliferation of keratino- cytes. Current existing therapies only relieve symptoms but cannot cure disease. Pilose Antler (PA) is a ...
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Collagen induced arthritis and imiquimod induced psoriasis develop independently of interleukin 33
... Background: Interleukin (IL)-33 is a dual cytokine with both an alarmin role and a T helper 2 cell (Th2)-like inducing effect. It is involved in the pathogenesis of rheumatoid arthritis (RA) and its models; we recently ...
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Comparison of normal versus imiquimod-induced psoriatic skin in mice for penetration of drugs and nanoparticles
... IMQ-induced psoriasis-like mouse model is a widely used pathological model for various in vivo evaluations. Besides the apparent simulation of psoriatic symptoms, the IL-23/ IL-17 axis also takes an important role ...
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The Toll-Like Receptor 7 (TLR7) Agonist, Imiquimod, and the TLR9 Agonist, CpG ODN, Induce Antiviral Cytokines and Chemokines but Do Not Prevent Vaginal Transmission of Simian Immunodeficiency Virus When Applied Intravaginally to Rhesus Macaques
... and imiquimod to prevent HSV-2 infec- tion in rodent models stands in stark contrast to the failure of these compounds to blunt vaginal SIV ...study induced inflammation in the vaginal mucosa of monkeys; in ...
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Imiquimod Cream in Low Concentrations as a New Topical Therapy for Melasma
... of imiquimod may occasionally occur. Among its adverse effects imiquimod – induced vitiligo which should be anticipated when dermatologists prescribe this drug ...
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<p>Cathepsin G cleaves and activates IL-36γ and promotes the inflammation of psoriasis</p>
... Taken together, our study has confirmed that CG has the ability to cleave and activate IL-36 γ to promote CXCL-1 and CXCL-8 expression by human keratinocytes, and CG can aggravate imiquimod-induced mouse ...
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Induction of vitiligo after imiquimod treatment of condylomata acuminata
... that imiquimod 5% cream was effective in treating condylomata ...ever, imiquimod not only kills the HPV but also destroys ...of imiquimod- induced vitiligo may be that the medication activates ...
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Cytokine Dermatitis and Febrile Seizure From Imiquimod
... topical imiquimod to systemic adverse ...“ imiquimod, ” “ seizure, ” “ carcinoma, ” and “ cytokine ...of imiquimod- induced dermatitis and subsequent fe- brile ...
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Imiquimod Suppresses Propagation of Herpes Simplex Virus 1 by Upregulation of Cystatin A via the Adenosine Receptor A1 Pathway
... with imiquimod under various conditions (pretreatment times and concentrations), infected with HSV-1 at an MOI of 1 or 10, and then incubated for 24 ...h. Imiquimod treatment (1 or 10 g/ ml) did not show ...
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Anti Cancer Activities and Interaction of Imiquimod and Flex Het, SHetA2, in Melanoma and Ovarian Cancer
... cancer. Imiquimod is an immune stimulant that induces apoptosis in cancer ...Both imiquimod and SHetA2 inhibited growth and induced apoptosis in the B16 melanoma cell line and cisplatin-sensitive ...
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Plasmacytoid dendritic cells lead the charge against tumors
... of imiquimod suppresses cutaneous melanoma by TLR7-dependent recruitment and transformation of plasmacytoid dendrit- ic cells into killer cells; this occurs independently of conventional adaptive immune ...
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Management of superficial basal cell carcinoma: focus on imiquimod
... comparing imiquimod with other interventions are not yet available although these are ...that imiquimod should not be first-line treatment for superficial BCC, as surgical excision is more ...
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