immune-checkpoint inhibition
Neurotoxicity from immune-checkpoint inhibition in the treatment of melanoma: a single centre experience and review of the literature.
... Immune-checkpoint inhibition is an established and effective treatment paradigm for patients with metastatic ...as immune-related neurological toxicities, which may have lasting ...
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Enhanced Anti-Tumor Efficacy through a Combination of Integrin αvβ6-Targeted Photodynamic Therapy and Immune Checkpoint Inhibition
... and immune checkpoint inhibition for inhibiting tumor growth and suppressing metastases in a 4T1 mouse breast cancer mouse ...metastasis inhibition were partial ra- ther than ...of ...
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The rationale for including immune checkpoint inhibition into multimodal primary treatment concepts of head and neck cancer
... multiple studies. Almost 20 years ago molecular pathways were first described that were activated by treatment- induced cell stress (in particular after treatment with anthracyclins and ionizing radiation) and which in- ...
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Seronegative autoimmune autonomic ganglionopathy from dual immune checkpoint inhibition in a patient with metastatic melanoma
... Hypothetically, the autoimmunity causing AAG and other ICI-related toxicities is triggered by autoreactive T-cells. Blocking PD-1 and CTL4 can disrupt important self-tolerance balances, thereby causing a host of auto- ...
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The complex relationship between body mass index and response to immune checkpoint inhibition in metastatic melanoma patients
... Conversely, an association with worse progression-free survival was observed in patients who received non-first line immune checkpoint inhibitors. Specifically, overweight and obese patients receiving ...
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Biomarkers in immune checkpoint inhibition therapy for cancer patients: what is the role of lymphocyte subsets and PD1/PD-L1?
... ICI: immune checkpoint therapy; ICOS: inducible co-stimulator; IFN: interferon; IFN- γ : interferon gamma; IHC: immuno histochemistry; IL-10: interleukin 10; IL-13/4: interleukin 13/4; IL-15: interleukin ...
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Isolated neutropenia as a rare but serious adverse event secondary to immune checkpoint inhibition
... Compared to conventional chemotherapy, ICIs have been noted to display distinct patterns of immune toxic- ities, commonly labeled as immune-related adverse events (irAEs). IrAEs differ from usual toxicities ...
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Immune checkpoint inhibition-related colitis: symptoms, endoscopic features, histology and response to management
... In this retrospective study on IRC, we have shown that there is no significant difference between patients with grade 2 or 3 diarrhoea with regard to endoscopic severity scores, histopathological features, the ...
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Thrombocytopenia in patients with melanoma receiving immune checkpoint inhibitor therapy
... by immune checkpoint inhibitors appears to be a relatively uncom- mon irAE that is manageable with standard treatment ...subsequent immune checkpoint ...the immune system, such as an ...
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Influenza vaccination of cancer patients during PD-1 blockade induces serological protection but may raise the risk for immune-related adverse events
... undergoing immune checkpoint inhibition, safety profiles for different vaccines has to be ...with immune checkpoint in- hibitors received a total of 53 prophylactic vaccinations ...
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The role of neoantigen in immune checkpoint blockade therapy
... Immune checkpoint inhibitor induces tumor rejection by activated host immune ...anti-tumor immune response consists of capture, presentation, recognition of neoantigen, as well as subsequent ...
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Is CD47 an innate immune checkpoint for tumor evasion?
... immune checkpoint to send a “don’t eat me” signal to en- sure that healthy autologous cells are not inappropriately phagocytosed. Consistent with this notion, CD47 −/− cells are cleared rapidly when they ...
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Immune-related adverse events and anti-tumor efficacy of immune checkpoint inhibitors
... IRAEs are thought to represent bystander effects from activated T-cells and it is plausible that patients responding to ICIs would have greater likelihood of autoimmune toxicities (e.g. due to a more ...
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Predictive biomarkers for tumor immune checkpoint blockade
... We have found that cancer patients with positive PD-L1 expression have a greater clinical benefit for immuno- therapy, but the detection of PD-L1 expression alone is not sufficient for most tumor subtypes. In this ...
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34th Annual Meeting & Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2019): part 1
... cells, checkpoint inhibitors, or novel bispecific antibodies, the ultimate goal is to modulate the immune system to harness its tumor killing ...in immune-regulated clearance of both liquid and solid ...
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Cancer immunotherapy beyond immune checkpoint inhibitors
... with immune checkpoint therapy are of concern including a response heterogeneity where some patients achieve a complete response (CR) but others never ...alternative immune escape mechanisms, and ...
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Monalizumab: inhibiting the novel immune checkpoint NKG2A
... Immuno-oncology has emerged as a revolution in cancer treatment. Unprecedented improvements in tumor control have been achieved with therapeutic blocking antibodies that release immune inhibitory ‘checkpoints’ ...
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Tumor Interferon Signaling Initiates And Sustains A Multigenic Resistance Program To Immune Checkpoint Blockade
... 2: Immune cells expressing PD-L1 mediate resistance to anti-CTLA4 and radiotherapy in relapse but not parental tumor lines ...to immune checkpoint blockade occurs in both mice and patients ...
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Exploiting Autoimmunity Unleashed by an Off-Label Low-Dose Immune Checkpoint Blockade to Treat Advanced Cancer
... immunotherapy. Immune-related adverse events (IrAEs) could affect any tissue, their incidence may reach up to 90% of patients and toxicity is ...two immune checkpoint inhibitors (ICIs) increased ...
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Smoldering myocarditis following immune checkpoint blockade
... following immune CPB has not been previously described, the natural history of this entity is unclear but may parallel viral ...auto- immune where initial viral infection of the myocardium leads to ...
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