immune-related adverse effects
Characteristics and management of immune-related adverse effects associated with ipilimumab, a new immunotherapy for metastatic melanoma
... common immune-related AEs that affect the gas- trointestinal tract manifest as diarrhea or ...gastrointestinal immune-related AEs include any changes in normal bowel habits or changes from ...
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Immune Checkpoint Inhibitor Related Neuropathic Adverse Effects on Cancer Patients
... application, immune checkpoint inhibitors (ICIs) intervention is being increasingly common for multiple ...as immune-related adverse effects (irAEs) ...of immune-modulating ...
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Durvalumab-induced diabetic ketoacidosis followed by hypothyroidism
... Immune-related adverse effects are being increasingly recognised as the use of ICIs rapidly rises (1). More agents are becoming available, as clinical indications for their use in advanced ...
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Immune-related adverse events and anti-tumor efficacy of immune checkpoint inhibitors
... bystander effects from activated T-cells and it is plausible that patients responding to ICIs would have greater likelihood of autoimmune toxicities ...competent/treatment-responsive immune system, or ...
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Unchecked immunity: a unique case of sequential immune-related adverse events with Pembrolizumab
... In this case, two of the four complications occurring many months after cessation of treatment, demonstrat- ing that checkpoint inhibition may result in long-lasting immune activation. Sequential irAEs affecting ...
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Concurrent therapy with immune checkpoint inhibitors and TNFα blockade in patients with gastrointestinal immune-related adverse events
... Patient 3 is a 70-year-old woman who was first diagnosed with melanoma at the age of 40 and underwent a surgical resection at the time. At the age of 62, she was diagnosed with recurrent metastatic melanoma to the bone ...
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Isolated neutropenia as a rare but serious adverse event secondary to immune checkpoint inhibition
... of immune toxic- ities, commonly labeled as immune-related adverse events ...ICI related clinical trials and retrospective studies have indicated the incidence of irAEs such as colitis, ...
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<p>Correlation of Immune-Related Adverse Events and Effects of Pembrolizumab Monotherapy in Patients with Non-Small Cell Lung Cancer</p>
... Pembrolizumab is highly effective in patients with PD-L1 positivity ≥ 50%. In this study, we showed that patients who developed irAEs had signi fi cantly increased PFS. Even in the landmark analysis, although the ...
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Multiple nivolumab-induced CNS demyelination with spontaneous resolution in an asymptomatic metastatic melanoma patient
... unregulated immune re- sponse with inflammatory or autoimmune side effects ...of immune-related adverse events (irAEs) [2–9, 11], includ- ing rare but severe (grade 3–4) neurological ...
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Combination regimens with PD-1/PD-L1 immune checkpoint inhibitors for gastrointestinal malignancies
... to immune monotherapy, several studies have shown that combined immunological regimens increase the in- cidences of all grade irAEs, especially for double im- munotherapy ...of adverse events in combination ...
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Management of pulmonary toxicity associated with immune checkpoint inhibitors
... specific immune-related adverse ...of immune-checkpoint inhibitors, the incidence of immune toxicity will continue to ...of immune-related adverse events is key to ...
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Immune-related adverse events with immune checkpoint inhibitors affecting the skeleton: a seminal case series
... Like the aforementioned conditions, ICI therapy pro- motes a pro-inflammatory state. In the setting of ICIs, activated T-cells secrete cytokines that assist in tumor cell destruction [24]. Cytokines implicated in ...
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<p>Immune-related adverse events following administration of anti-cytotoxic T-lymphocyte-associated protein-4 drugs: a comprehensive systematic review and meta-analysis</p>
... xed effects model or random effects model (using the inverse var- iance method) was adopted for the meta-analysis accord- ing to the ...random effects model was ...
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Weighing up the pros and cons of immune checkpoint inhibitors in the treatment of melanoma.
... al. Immune-Related Adverse Events, Need for Systemic Immunosuppression, and Effects on Survival and Time to Treatment Failure in Patients With Melanoma Treated With Ipilimumab at Memorial ...
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Neurologic immune-related adverse events associated with adjuvant ipilimumab: report of two cases
... A 39-year-old Caucasian female was diagnosed with nodular melanoma of the right upper back following a biopsy. Wide local excision (WLE) and right axillary sentinel lymph node (SLN) biopsy were performed; al- though WLE ...
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<p>Risk of immune-related adverse events associated with ipilimumab-plus-nivolumab and nivolumab therapy in cancer patients</p>
... clinical trials. However, their search strategy was limited and included cases only up to December 2016. Anti-CTLA4 therapy was associated with a higher risk of overall irAEs. Anti-PD1 therapy was associated with a ...
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Pembrolizumab-induced Hemophagocytic Lymphohistiocytosis: an immunotherapeutic challenge
... HLH is an uncommon yet life-threatening hematologic dis- order characterized by aberrant immune-cell activation, pro-inflammatory cytokine release, and multi-organ dys- function. HLH is diagnosed based on meeting ...
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Pericardial Effusion with Tamponade, an Immune Related Adverse Event Associated with Nivolumab Therapy: A Case Report and Review of the Literature
... cardiovascular adverse events reported in patients who received immune check- point inhibitors ...after immune checkpoint inhibi- tors administration with a median time to the onset of pericardial ...
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The role of placebo effects in immune-related conditions: Mechanisms and clinical considerations
... placebo effects as efficacy was found to be much greater for placebo administration through injections than placebo ’ s in pill form ...placebo effects in osteoar- thritis patients, where more invasive ...
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Effect of the protein corona on nanoparticles for modulating cytotoxicity and immunotoxicity
... control immune responses and ...the immune system, the adverse aspects of NPs will be antici- pated in advance and inhibited through rational ...
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