Immune Tolerance
Cytokine regulation of immune tolerance
... It is well-recognized that not all self-reactive T cells are eliminated in the thymus. A traditional viewpoint suggests that peripheral tolerogenic mechanisms (e.g., T cell anergy, exhaustion, deletion, or Treg ...
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Apoptotic cell-linked immunoregulation: implications for promoting immune tolerance in transplantation
... Notably, iDCs also produce TGF-β through the phago- cytosis of apoptotic cells and thus contribute to apop- totic cell-linked immune tolerance. iDCs express lower levels of the co-stimulatory molecules ...
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Durable and sustained immune tolerance to ERT in Pompe disease with entrenched immune responses
... long-term immune tolerance in the setting of an entrenched immune response to a lifesaving therapeutic ...While immune tolerance in IPD has been achieved in the ERT-naive setting using ...
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The expression of selected molecular markers of immune tolerance in psoriatic patients
... Background. Psoriasis is a chronic autoinflammatory disease whose underlying molecular mechanisms remain unclear. The disease is mediated by the cells and molecules of both the innate and adaptive immune systems. ...
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Goblet cell loss abrogates ocular surface immune tolerance
... conjunctival immune tolerance in Spdef-KO ...surface immune tolerance has been observed in experimentally induced mouse dry eye models where GC loss occurs (9, ...induce tolerance to ...
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High-dose of intravenous immunoglobulin modulates immune tolerance in premature infants
... temporary immune tolerance could be a benefit in premature infants for restoring system homeo- stasis; however, the cytokine profile changes, such as in- creasing TGF- β and decreasing IL-6, which also ...
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A20 as an immune tolerance factor can determine islet transplant outcomes
... heavy immune suppression to prevent ...of immune cells by raising NF-kB signaling ...favor immune tolerance and promotes islet allogeneic ...
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Cost-utility analysis of immune tolerance induction therapy versus on-demand treatment with recombinant factor VII for hemophilia A with high titer inhibitors in Iran
... QoL, immune tolerance induction (ITI), eg, the regular infusion of FVIII concentrates over a time period ranging from months to years, is usually attempted to overpower high responding (anamnesis) FVIII ...
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Analysis on Immune Tolerance and Resistance Mechanism of Cryptococcus albidus of AIDS Patients with Opportunistic Cryptococci Infection
... Objective: To explore more about the immune tolerance and drug resistance of white Cryptococci albidus in AIDS patients with opportunistic Cryptococcus infection. Methods: To analyze drug re- sistance of ...
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Immune tolerance improves the efficacy of enzyme replacement therapy in canine mucopolysaccharidosis I
... made immune tolerant to rhIDU using the 60-day immunosuppressive regimen (cyclosporine A and azathioprine) coupled with weekly infusions of low-dose ...patients. Immune tolerance was defined as a ...
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Immune cell trafficking from the brain maintains CNS immune tolerance
... to immune surveillance has been characterized for preventing the anti-CNS immune responses that develop in autoimmune neuroinflammatory ...for immune cells to traffic from the brain that is ...
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Working toward immune tolerance in lung transplantation
... host immune regulation, even without generating durable spe- cific immune tolerance, is a worthwhile goal for ...prope tolerance was advanced origi- nally to explain success achieved in kid- ...
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Gene Therapy Approaches To Immune Tolerance Induction In Canine Hemophilia
... first described when it was observed that frequent administration of large doses of FVIII could reduce inhibitor titers over time 91 . Currently, there are many variations of ITI, but they all have in common continuous ...
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Viral Infections and Autoimmune Disease: Roles of LCMV in Delineating Mechanisms of Immune Tolerance
... of tolerance to islet antigens through mechanisms known today as molecular mimicry (a phenomenon where sequence similarities between foreign and self-peptides result in the cross-activation of autoreactive T or B ...
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Inhibition of hyaluronan synthesis restores immune tolerance during autoimmune insulitis
... It is notable that substantial intraislet HA deposits persisted, despite 4-MU treatment. Since 4-MU works at the level of HA synthesis (rather than clearance or catabolism), we suspect that it may take time for HA at ...
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T cells expressing chimeric antigen receptor promote immune tolerance
... Here, we used multiple systems to demonstrate that the introduction and transient expression of a CAR construct in adoptively transferred Tcons or Tregs permitted remarkable experimental control of T cell local- ization ...
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Immune Tolerance Split between Hepatitis B Virus Precore and Core Proteins
... anti-HBe (Fig. 11, top panel). Induced anti-HBc/HBe antibody production in TCR/Ag double-Tg mice was examined by in- jecting the 7/16–5 TCR-specific peptide p129-140. High- and low-HBcAg-expressing double-Tg mice could ...
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Recombinant Lactococcus lactis can make the difference in antigen-specific immune tolerance induction, the Type 1 Diabetes case
... lifestyle [97,98]. The manifestations of these diseases come in a wide variety, from “unpleasant” to “life threa- tening when left untreated” . Despite our growing mechanistic understanding, the current standard of care ...
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A Golden Anniversary: Cattle Twins and Immune Tolerance
... RAY OWEN, a postdoctoral fellow in the laboratory and already interested in blood groups of cattle twins, thought they would provide an interesting opportunity for blood [r] ...
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Poly and autoreactivity of HIV 1 bNAbs: implications for vaccine design
... immunological tolerance plays in barring the generation of many bNAbs, there are at least two potential strategies for a universal HIV-1 vac- ...“breaks” tolerance to gain access to bNAb pre- cursors in the ...
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