Immunity and Malaria
Population level effects of clinical immunity to malaria
... clinical immunity to malaria are more complex than those in our simple model: in particular, clinical immunity continues to develop, there is not sim- ply one kind of clinical ...planning ...
11
Gradual acquisition of immunity to severe malaria with increasing exposure
... of immunity to severe disease to the age distribution of severe malaria cases stratified by symp- toms from a range of transmission settings in Tanzania, combined with data from several African countries on ...
8
Gradual acquisition of immunity to severe malaria with increasing exposure
... of immunity to severe disease to the age distribution of severe malaria cases stratified by symp- toms from a range of transmission settings in Tanzania, combined with data from several African countries on ...
9
Malaria preventive therapy in pregnancy and its potential impact on immunity to malaria in an area of declining transmission
... low malaria prevalence may have reduced the power to observe any potential im- pact of different treatment arms on the acquisition of pregnancy-associated malaria ...duced malaria exposure in this ...
8
Cross species malaria immunity induced by chemically attenuated parasites
... of malaria has focused on the induction of antibodies to parasite surface antigens, most of which are highly ...independent immunity to different ...profound immunity to different malaria ...
11
Opsonising antibodies to P. falciparum Merozoites associated with immunity to clinical malaria
... Interestingly, no association with reduced incidence of clinical episodes and opsonising antibody responses was observed in children who were parasitaemic at baseline. Asymptomatic carriage of P. falciparum, as ...
8
Age structured gametocyte allocation links immunity to epidemiology in malaria parasites
... by malaria prevalence rates that provide a gross measure of the force of infection and gradual development of immu- ...of immunity that generates age structure and is thus pre- ...contrast, malaria ...
9
Innate immunity in the malaria vector Anopheles gambiae: comparative and functional genomics
... innate immunity and the molecular interactions occurring between the vector and the parasite was a distant ...human malaria parasite, ...rodent malaria parasite, ...rodent malaria parasite ...
13
Loss and recovery of Humoral Immunity to Influenza Virus following Malaria Infection
... acquired immunity to malaria is gradual and requires uninterrupted heavy exposure, and protective Abs are rapidly lost upon cessation of exposure or after receiving medical treatment (Cavanagh et ...to ...
247
Innate immunity in HIV, helminth and malaria co-infections : effects on experimental TB vaccination and clinical malaria presentation
... during malaria infection, as one part of malaria pathogenicity is gut barrier dys- function and e ux of endotoxins into the ...asymptomatic malaria and co-infection was ...
246
Implications of population level immunity for the emergence of artemisinin resistant malaria: a mathematical model
... resistant malaria falciparum strains to the detection of confirmed partial artemisinin resistance is multifactorial and inde- pendently related to malaria prevalence, immunity and drug ...
11
Evaluation of immunity against malaria using luciferase expressing Plasmodium berghei parasites
... direct comparison of the characteristics of P. yoelii and P. berghei in vivo. Evaluation of immunity against malaria by biolumines- cent imaging offers many advantages over conventional qRT-PCR analysis. ...
7
Quantification of anti-parasite and anti-disease immunity to malaria as a function of age and exposure.
... symptomatic malaria upon each subsequent ...in malaria transmission in sub-Saharan Africa that are largely attributable to increased access to effective control measures, including insecticide- treated ...
21
Evidence for significant influence of host immunity on changes in differential blood count during malaria
... The distinct difference of relative white blood cell count and both ratios depending on the immune status against malaria was the most interesting finding in this study. However, data have to be interpreted with ...
9
Linking environmental variability to village scale malaria transmission using a simple immunity model
... of immunity, preva- lence in Zindarou significantly decreases and approaches Banizoumbou ...scale malaria prevalence is largely independent of hydro- logic conditions, according to the model the danger to ...
14
The Role of Complement in Antibody-Dependent Acquired Immunity to <i>Plasmodium falciparum</i> Malaria
... power and using carefully selected cases and control and head to head comparison using similar antigens are warranted to shed a light of the importance of antibody levels and susceptibility to severe malaria ...
251
Neutralization of the Plasmodium-encoded MIF ortholog confers protective immunity against malaria infection
... from malaria caused by parasites of the genus Plasmodium 1 ...of malaria 2 ...lethal malaria but survivors may develop partial immunity and tolerance to disease manifes- ...sterilize ...
13
Bridging the Knowledge Gap in Transmission Blocking Immunity to Malaria: Deciphering Molecular Mechanisms in Mosquitoes
... of malaria does not mean an end to the universal problem of malaria pathogenesis in those afflicted by ...of malaria has impeded progress towards a transmission-blocking ...transmission-blocking ...
9
Impact of Human Immunodeficiency Virus Infection in Pregnant Women on Variant-Specific Immunity to Malaria
... Our observation that HIV ⫹ multigravidae were more likely than primigravidae and secundigravidae to have impaired an- tibody responses to pediatric isolates was unexpected. The levels of immunosuppression (as measured by ...
5
Opsonic phagocytosis of Plasmodium falciparummerozoites: mechanism in human immunity and a correlate of protection against malaria
... protective immunity against Plasmodium falciparum malaria in humans is currently very limited, and this has been a major barrier to vaccine ...In malaria-endemic areas the severity and frequency of ...
15