Immunodominant Epitopes
Identification of Immunodominant Epitopes on the Membrane Protein of the Severe Acute Respiratory Syndrome Associated Coronavirus
... the immunodominant epitopes induced potent antibody re- sponses in the immunized rabbits, highlighting the immunoge- nicity of M ...The immunodominant sequences that elicit neutraliz- ing antibodies ...
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Identification of immunodominant epitopes of e1 and nucleocapsid proteins of chikungunya virus with neutralizing capacity
... and nsP4) and five structural proteins viz. Capsid, E1, E2, E3 and 6K (Jose et al., 2009). E2 glycoprotein interacts with a cellular receptor while E1 glycoprotein mediates virus fusion to host cell under low pH ...
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Analysis of Genetic Variability within the Immunodominant Epitopes of Envelope gp41 from Human Immunodeficiency Virus Type 1 (HIV 1) Group M and Its Impact on HIV 1 Antibody Detection
... The serodiagnosis of human immunodeficiency virus type 1 (HIV-1) infection primarily relies on the detec- tion of antibodies, most of which are directed against the immunodominant regions (IDR) of HIV-1 structural ...
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Anti-adenovirus type 5 cytotoxic T lymphocytes: immunodominant epitopes are encoded by the E1A gene.
... Lisle Research Laboratory in Immunology and Tumor Cell Biology, Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Departments of Medicine4 a[r] ...
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Antibody reactivity to the immunodominant epitopes of the caprine arthritis-encephalitis virus gp38 transmembrane protein associates with the development of arthritis.
... By combining library screening with sera from naturally infected Swiss goats with an enzyme immunoassay with overlapping peptides pepscan, four group-specific epitopes could be precisely[r] ...
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Immunogenicity of Recombinant Proteins Consisting of Plasmodium vivax Circumsporozoite Protein Allelic Variant-Derived Epitopes Fused with Salmonella enterica Serovar Typhimurium Flagellin
... central immunodominant repeat re- ...3 immunodominant epitopes of the ...representative epitopes from the 3 allelic forms (All-CS-epitopes) was ...3 immunodominant ...
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Inexpensive Designer Antigen for Anti-HIV Antibody Detection with High Sensitivity and Specificity
... HIV-specific immunodominant epitopes from all known genotypes and ex- pressed to high levels in an ...selected immunodominant, linear, and phylogenetically conserved epitopes from these ...
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Peptide-Based Antibody Detection for Tuberculosis Diagnosis
... Tuberculosis (TB) is a major cause of morbidity and mortality, especially in developing countries. Despite significant limitations, microscopy remains the cornerstone of the global TB control strategy. As the TB epidemic ...
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Characterization and Epitope Mapping of the Polyclonal Antibody Repertoire Elicited by Ricin Holotoxin-Based Vaccination
... four immunodominant epitopes, three of which are located on the A subunit and one on the B subunit of ...four epitopes were found to have a significant role in ricin neutral- ...
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Immunodominant CD4+ T-Cell Responses to Influenza A Virus in Healthy Individuals Focus on Matrix 1 and Nucleoprotein
... antigenic epitopes even during immune responses to complex an- tigens or pathogens in immunized or infected ...ally, immunodominant T cells are not only more prevalent, but also provide better protection ...
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Variability and Immunogenicity of Caprine Arthritis-Encephalitis Virus Surface Glycoprotein
... B epitopes. No group-specific epitopes were identified within the V1 and V2 hypervariable regions and the less-variable V3 ...two immunodominant epitopes included in peptide P75, suggesting ...
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Analysis of Pigtail Macaque Major Histocompatibility Complex Class I Molecules Presenting Immunodominant Simian Immunodeficiency Virus Epitopes
... at immunodominant epitopes, resulting in disease progression (10, 11, 13, ...subdominant epitopes in this study, such as YP8 (restricted by Mane-A*11/ Mane-A*12) and KW9 (restricted by Mane-A*14 or ...
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Generation of cytotoxic T lymphocytes against immunorecessive epitopes after multiple immunizations with adenovirus vectors is dependent on haplotype.
... CTL epitopes, the CTL response is dominated by a few immunodominant epitopes (3, ...three epitopes that vary with the major histocompatibility complex (MHC) class I allele (28, ...
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Design and evaluation of a recombinant multi epitope antigen for serodiagnosis of Toxoplasma gondii infection in humans
... the epitopes of several ...synthesized immunodominant epitopes within ...peptide epitopes are effective in dis- criminating between recently acquired infection and past infection; thus, they ...
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Identification of Immunodominant and Conformational Epitopes in the Capsid Protein of Hepatitis E Virus by Using Monoclonal Antibodies
... against immunodominant epitopes in HEV (21), and an analogous protein, ...2E2 epitopes in full-length ...the epitopes for MAbs 4B2 and 2E2 are of particular ...
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Manipulation of immunodominant dengue virus E protein epitopes reduces potential antibody dependent enhancement
... pathogenic, immunodominant epitopes, we have altered the antibody response to reduce the potential for ADE and begin to scratch the surface of immune re- focusing approaches in DENV vaccine ...
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Characterization of Immunodominant Linear B-Cell Epitopes on the Carboxy Terminus of the Rinderpest Virus Nucleocapsid Protein
... especially immunodominant epitopes, that would be very use- ful for diagnostic applications remain ...contain immunodominant antigenic sites, as found in N protein of Sendai virus, one of the mor- ...
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Development of Recombinant Chimeric Antigen Expressing Immunodominant B Epitopes of Leishmania infantum for Serodiagnosis of Visceral Leishmaniasis
... carry immunodominant epitopes which can be useful for serological diagnosis of canine ...Leishmania immunodominant epitopes se- lected; notably, none of 13 sera from Chagas’ disease patients ...
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Identification of Immunodominant B- and T-Cell Combined Epitopes in Outer Membrane Lipoproteins LipL32 and LipL21 of Leptospira interrogans
... engineer epitopes for increased potency and breadth, and the ability to focus immune responses on conserved epitopes ...effective immunodominant epitopes is an initial and critical ...combined ...
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Identification of Immunodominant Neutralizing Epitopes on the Hemagglutinin Protein of Rinderpest Virus
... The immunodominant epitopes on the hemagglutinin protein of rinderpest virus (RPV-H) were determined by analyzing selected monoclonal antibody (MAb)-resistant mutants and estimating the level of antibody ...
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