Immunodominant Region
Human organ specific autoimmune disease Molecular cloning and expression of an autoantibody gene repertoire for a major autoantigen reveals an antigenic immunodominant region and restricted immunoglobulin gene usage in the target organ
... The most common organ-specific autoimmune disease in humans involves the thyroid. Autoantibodies against thyroid peroxidase (TPO) are present in the sera of virtually all patients with active disease. We report the ...
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Hybrid hepatitis B virus nucleocapsid bearing an immunodominant region from hepatitis B virus surface antigen.
... 3696-3701 0022-538X/93/063696-06$02.00/0 Copyright © 1993, American Society for Microbiology Hybrid Hepatitis B Virus Nucleocapsid Bearing an Immunodominant Region from Hepatitis B Virus[r] ...
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Evaluation of the Recombinant 10-Kilodalton Immunodominant Region of the BP26 Protein of Brucella abortus for Specific Diagnosis of Bovine Brucellosis
... Cloning and expression of the 10-kDa gene fragment. The gene fragment (282 bp) encoding the immunodominant region of BP26 was amplified by PCR, and the amplicon was cloned into the pQE-30 UA vector. The ...
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Antibody responses to Four Corners hantavirus infections in the deer mouse (Peromyscus maniculatus): identification of an immunodominant region of the viral nucleocapsid protein.
... nus deletions up to aa 59 (pFCV-S-CEx220) (Fig. 2, panels 2B and 3B, lanes 19 to 23). There was no detectable reactivity with the pFCV-S-CEx170 protein (aa 1 to 41) and proteins that contained more extensive ...
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Dogs Vaccinated with Common Lyme Disease Vaccines Do Not Respond to IR6, the Conserved Immunodominant Region of the VlsE Surface Protein of Borrelia burgdorferi
... In fact, serum specimens from dogs that had received the recommended two-dose regimen of whole-cell (bacterin) or recombinant OspA vaccines had IFA titers rang- ing from 800 to 1,600 at [r] ...
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Molecular analyses of a five-amino-acid cytotoxic T-lymphocyte (CTL) epitope: an immunodominant region which induces nonreciprocal CTL cross-reactivity.
... In contrast, the four anti-NP clones shown here mirrored the Primary anti-LCMV ARM splenic CTL and various CTL clones were incubated with H-2d targets which were either uninfected, coate[r] ...
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Conservation of Type Specific B Cell Epitopes of Glycoprotein G in Clinical Herpes Simplex Virus Type 2 Isolates
... limited region of mgG-2 (10, 17, 22), the fine specificity of those epitopes may differ, or residues other than those described here for the MAbs may have a key im- portance for ...the immunodominant ...
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Continuous epitopes of the human immunodeficiency virus type 1 (HIV-1) transmembrane glycoprotein and reactivity of human sera to synthetic peptides representing various HIV-1 isolates.
... 18 identified only one or possibly two epitopes in the immunodominant region of gp4l recognized by HIV-1 antibody-positive human sera; this was done by using variants of a 23-aa peptide [r] ...
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Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer’s disease and frontotemporal dementia
... Methods: In this study, we genetically fused tau 294 – 305 epitope to the hepatitis B virus core protein (HBc) major immunodominant region (MIR) (with the resultant protein termed T294-H[r] ...
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Identification of Human Immunodeficiency Virus Type 1 Subtype C Gag-, Tat-, Rev-, and Nef-Specific Elispot-Based Cytotoxic T-Lymphocyte Responses for AIDS Vaccine Design
... highlighting immunodominant regions ...The immunodominant region is delineated with a dashed ...identified immunodominant region within HIV-1C ...identified immunodominant ...
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Bacillus pumilus: Possible Model for the Bioweapon Bacillus anthracis
... Mujer, “Proteomic Profiling and Identification of Immunodominant Spore Antigens of Bacillus anthracis, Bacillus cereus and Bacillus thuringiensis,” Applied and Environmental Microbiology[r] ...
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Determination of Immunodominant Antigens of Dicrocoelium Dendriticum by Hyperimmune Sera
... as immunodominant protein, could be considered for the immunodiagnosis of dicrocoeliasis and it probably induces protective immunity against Dicrocoelium ...
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Specificity of antibodies to immunodominant mycobacterial antigens in pulmonary tuberculosis
... RESULTS Definition of cutoff points between patient and control The titers of IgG antibodies in human sera were determined in groups of patients with active smear-positive or smear-negat[r] ...
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BBK07 Immunodominant Peptides as Serodiagnostic Markers of Lyme Disease
... The B. burgdorferi lipoprotein BBK07 was identified as an immunodominant antigen in a study by Barbour et al. (6). We have recently shown that BBK07 is an in vivo-induced surface antigen which is selectively ...
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An immunodominant domain in adenovirus type 2 early region 1A proteins.
... antibodies in the rabbit mately 90% of the protein A-binding polyclonal antiserum bind to the sa'me epitope or overlapping epitopes that are recognized by the s'ix rat MAbs and substanti[r] ...
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B-Cell Responses in Patients Who Have Recovered from Severe Acute Respiratory Syndrome Target a Dominant Site in the S2 Domain of the Surface Spike Glycoprotein
... the immunodominant sites responsible for the beneficial humoral and cellular immune responses in convalescent SARS patients, such as the antigens determined in this study and the T-cell epitopes that have begun to ...
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Designing and Construction of Recombinant Plasmid Consisting of Basic Fibroblast Growth Factor and Immunodominant Fragments of Pseudomonas Exotoxin
... the bFGF and immunodominant epitopes of Pseudomonas toxin. Material and Methods: Different types of peptide linker, codon adaptation index (CAI) and adding signal peptide were considered in designing of ...
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Diagnostic value of anti Candida enolase antibodies
... An immunodominant antigen with enolase enzyme activity was purified and used for the development of an assay to detect antibodies directed against this antigen in sera from patients with[r] ...
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Designing, Optimizing, and Structure Prediction of Chimeric Protein CTB-IpaD for Expression in E.coli
... The most common cause of diarrhea is Shigella and no vaccine has been found to provide protection against it. IpaD play an important role in invasion, infection, and pathogenesis caused by Shigella. This protein has been ...
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CD8+ Lymphocytes from Simian Immunodeficiency Virus-Infected Rhesus Macaques Recognize 14 Different Epitopes Bound by the Major Histocompatibility Complex Class I Molecule Mamu-A*01: Implications for Vaccine Design and Testing
... For example, it is interesting that in animals 95024 and 95114, the Gag_CM9 epitope was not the most immunodominant, and Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest [r] ...
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