Immunogenic cell death
Immunogenic cell death due to a new photodynamic therapy (PDT) with glycoconjugated chlorin (G-chlorin)
... for immunogenic cell ...cancer cell selectivity and effectively suppresses the growth of xenograft ...induced immunogenic cell death in a mouse model, where the immunogenicity of ...
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Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma
... Recently, immunogenic cell death (ICD) has been considered as the best way to induce an adaptive immune response and improve the efficacy of anti- cancer treatment ...a cell death ...
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DNA damage predicts prognosis and treatment response in colorectal liver metastases superior to immunogenic cell death and T cells
... In murine models, tumor-derived deoxyribo- nucleic acid (DNA), incorporated by DCs, is capable of activating the stimulator of interferon genes (STING) pathway, resulting in type I IFN production [22, 23]. The STING ...
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Complementary Induction of Immunogenic Cell Death by Oncolytic Parvovirus H-1PV and Gemcitabine in Pancreatic Cancer
... of immunogenic cell death (ICD), coupling oncolysis with immune responses via calreticu- lin, ATP, and high-mobility group box protein B1 (HMGB1) release from dying tumor ...interconnected ...
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Dinaciclib induces immunogenic cell death and enhances anti PD1–mediated tumor suppression
... induce immunogenic cell death (ICD) within the ...or cell-surface expression of highly immunostimulatory damage- associated molecular patterns (DAMPs) by the dying tumor ...cancer ...
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Immunogenicity of oncolytic vaccinia viruses JX-GFP and TG6002 in a human melanoma in vitro model: studying immunogenic cell death, dendritic cell maturation and interaction with cytotoxic T lymphocytes
... an immunogenic type of cell death in a human melanoma cell model using SK29-MEL melanoma ...on cell viability followed a time- and multiplicity of infection dependent ...of cell ...
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Concepts and mechanisms underlying chemotherapy induced immunogenic cell death: impact on clinical studies and considerations for combined therapies
... tumor cell antigens (generated by heat shock or irradiation), levels of CALR exposure on cancer cells provided an independent prognostic marker ...a cell signaling cascade that inhibits phagocytosis [136, ...
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Immunogenic cell death
... the cell death stimulus and the mo- lecular nature and mediators of the danger signalling it ...of cell stress pathways, such as autophagy, which are clinically ...
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Immunogenic cell death induced by a new photodynamic therapy based on photosens and photodithazine
... the cell death induced by PD-PDT was blocked only by the apoptosis in- hibitor ...ferroptotic cell death in GL261 cells. Ferroptosis is a regulated type of cell death resulting ...
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Resveratrol induces immunogenic cell death of human and murine ovarian carcinoma cells
... MTT cell viability assay ...1c. Cell apoptotic response to RES was further assessed, and the viable cells were tremendously decreased, as indicated by the green fluorescence accompanying with oppositely in- ...
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Measles virus causes immunogenic cell death in human melanoma
... Around six OV have made progress into early phase clinical trials 21 . MV, in addition to its long history of administration as a vaccine, has been safely delivered in patients with a variety of tumours by intravenous, ...
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Oncolytic viruses as immunotherapy: progress and remaining challenges
... Abstract: Oncolytic viruses (OVs) comprise an emerging cancer therapeutic modality whose activity involves both direct tumor cell lysis and the induction of immunogenic cell death (ICD). ...
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Capsaicin triggers immunogenic PEL cell death, stimulates DCs and reverts PEL-induced immune suppression
... apoptotic cell death in PEL cells correlated with the inhibition of ...mediated cell death and autophagy ...an immunogenic cell death, directly promoted DC activation and, ...
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Specific microtubule-depolymerizing agents augment efficacy of dendritic cell-based cancer vaccines
... Apoptotic cell death was previously recognized mainly as being tolerogenic, whereas necrosis was considered ...apoptotic cell death also can induce immunogenic cell death ...
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Combining DNA damaging therapeutics with immunotherapy: more haste, less speed.
... Kepp O, Senovilla L, Vitale I, Vacchelli E, Adjemian S, Agostinis P, Apetoh L, Aranda F, Barnaba V, Bloy N, Bracci L, Breckpot K, Brough D, Buqué A, Castro MG, Cirone M, Colombo MI, Cremer I, Demaria S, Dini L, ...
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Cancer immunotherapy via combining oncolytic virotherapy with chemotherapy: recent advances
... Abstract: Oncolytic viruses are multifunctional anticancer agents with huge clinical potential, and have recently passed the randomized Phase III clinical trial hurdle. Both wild-type and engineered viruses have been ...
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Virotheranostics, a double-barreled viral gun pointed toward cancer; ready to shoot?
... ICD: Immunogenic cell death; APCs: Antigen present- ing cells; NK: Natural killer; MHC-I: Major histocompatibility complex class-I; CTL: Cytotoxic T-lymphocytes; PRRs: Pattern recognition receptors; ...
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Hardanahalli
... Background: In India, presently there are two purified chick embryo cell culture vaccines (PCECV) viz., Rabipur (Flury LEP strain) and Vaxirab – N (Pitman Moore strain) which are commonly used both in public as ...
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“Prediction of Peptide Vaccine Candidate for Dairy Products Borne Human Botulism” by Pallavi Mishra, S.Velavan, India.
... To overcome the human botulism caused by Neurotoxin (BoNT) A, B, E and F of C. botulinum is a major challenge to scientific community. This challenge can be faced successfully either with antibiotics or with immunologic ...
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K+ATP CHANNELS MODULATE HAEMODYNAMICS, BIOCHEMICAL AND HEMATOLOGICAL AFTER PRETREATMENT WITH THE K (ATP) OPENER PINACIDIL AND PHOSPHOLIPASE C INHIBITOR ON ETOMIDATE IN THE MICE
... induce cell death in different cell lines, being reported mainly apoptosis and necrosis as the principal pathways of cell death mediated by blockage of K + channels or the Na, K-ATPase, ...
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