Immunoglobulin G1
Chimpanzee Fab Fragments and a Derived Humanized Immunoglobulin G1 Antibody That Efficiently Cross-Neutralize Dengue Type 1 and Type 2 Viruses
... Passive immunization with monoclonal antibodies from humans or nonhuman primates represents an attractive alternative to vaccines for prevention of illness caused by dengue viruses (DENV) and other flaviviruses, ...
9
Coxsackievirus Expression of the Murine Secretory Protein Interleukin-4 Induces Increased Synthesis of Immunoglobulin G1 in Mice
... We cloned the sequence encoding murine interleukin-4 (mIL-4), including the secretory signal, into the genome of CVB3/0, an artificially attenuated strain of coxsackievirus B3, at the junction of the capsid protein 1D ...
11
Monoclonal Immunoglobulin G1 Directed against Aspergillus fumigatus Cell Wall Glycoprotein Protects against Experimental Murine Aspergillosis
... ically improved the specificity of immune procedures. Some of the many applications of MAbs are immunochemical charac- terization and purification of bacterial, fungal, or viral anti- gens; localization of viral and ...
6
Molecular Features of the Broadly Neutralizing Immunoglobulin G1 b12 Required for Recognition of Human Immunodeficiency Virus Type 1 gp120
... of immunoglobulin G1 (IgG1) b12 allowed modeling of the b12-gp120 interaction in which the protruding third complementarity-determining region (CDR) of the heavy chain (H3) was crucial for antibody ...
14
Distinct Contributions of Vaccine-Induced Immunoglobulin G1 (IgG1) and IgG2a Antibodies to Protective Immunity against Influenza
... Vaccination represents the most effective form of protection against influenza infection. While neutralizing antibodies are typically measured as a correlate of vaccine-induced protective immunity against influenza, ...
10
Immunoglobulin G1 Enzyme-Linked Immunosorbent Assay for Diagnosis of Johne's Disease in Red Deer (Cervus elaphus)
... This study was designed to develop a customized enzyme-linked immunosorbent assay (ELISA) for the serodiagnosis of Johne’s disease (JD) in farmed deer. Two antigens were selected on the basis of their superior diagnostic ...
9
Assignment of Immunoglobulin G1 and G2 Concentrations to Pneumococcal Capsular Polysaccharides 3, 6B, 14, 19F, and 23F in Pneumococcal Reference Serum 89-SF
... of immunoglobulin isotypes, including measurement of concentrations of isotypes after purification of specific antibody (26) or measurement of specific antibody after physical separation of immunoglobulin ...
6
Enzyme immunoassay for anti hepatitis B core (HBc) immunoglobulin G1 and significance of low level results in competitive assays for anti HBc
... On class and subclass determination for confirmation of positivity for anti-HBc in 19 serum samples, which was identified by screening of blood from 1,343 donors by a competitive EIA Hep[r] ...
5
An Immunoglobulin G1 Monoclonal Antibody Highly Specific to the Wall of Cryptosporidium Oocysts
... The detection of Cryptosporidium oocysts in drinking water is critically dependent on the quality of immu- nofluorescent reagents. Experiments were performed to develop a method for producing highly specific antibodies ...
6
Anti-Trypanosoma cruzi Immunoglobulin G1 Can Be a Useful Tool for Diagnosis and Prognosis of Human Chagas' Disease
... of immunoglobulin G (IgG) subclasses of CSA and LA were analyzed by flow cytometry using serum samples from chronic chagasic patients with the indeterminate (IND), cardiac (CARD), and digestive (DIG) clinical ...
7
The Binding of Human Immunoglobulin G1 Monomer and Small, Covalently Cross Linked Polymers of Immunoglobulin G1 to Human Peripheral Blood Monocytes and Polymorphonuclear Leukocytes
... In the following studies, comparing the binding of monoclonal human IgGI to PMN and monocytes, marked differences in the number of Fc receptors per cell and in the avidity with which the[r] ...
9
Differential binding of immunoglobulin A and immunoglobulin G1 immune complexes to primate erythrocytes in vivo Immunoglobulin A immune complexes bind less well to erythrocytes and are preferentially deposited in glomeruli
... The results indicate that, compared with IgGl-IC, IgA-IC bind less well to primate erythrocytes, are cleared from the circulation more quickly despite their smaller size, and show increa[r] ...
9
Managing refractory Crohn's disease: challenges and solutions
... humanized immunoglobulin G1 monoclonal antibody to integrin α 4 β 7, demonstrated that patients with active CD treated using vedolizumab were more likely than patients receiving placebo to have a remission ...
10
A role for urokinase-type plasminogen activator in human immunodeficiency virus type 1 infection of macrophages.
... murine immunoglobulin G1 (IgG1) antibody to the uPA catalytic site (antibody 394; American Diagnostica); (ii) IgG1 antibody to the uPA receptor-binding domain (antibody 3921; Amer- ican Diagnostica); (iii) ...
6
Evaluation of Human Monoclonal Antibody 80R for Immunoprophylaxis of Severe Acute Respiratory Syndrome by an Animal Study, Epitope Mapping, and Analysis of Spike Variants
... 80R immunoglobulin G1 (IgG1), a human monoclonal antibody against severe acute respiratory syndrome coronavirus (SARS-CoV) spike (S) protein that acts as a viral entry inhibitor in vitro, was investigated ...
7
Emerging treatments and combinations in the management of NSCLC: clinical potential of nintedanib
... human immunoglobulin G1 monoclonal antibody that targets the extracellular domain of VEGF receptor 2, to docetaxel demonstrated significant improvement in the primary endpoint of median overall sur- vival ...
10
Immunogenic and Functional Organization of Hepatitis C Virus (HCV) Glycoprotein E2 on Infectious HCV Virions
... of immunoglobulin G1 human monoclonal antibodies (HMAbs) to three immunogenic conformational domains (designated A, B, and C) on HCV E2 glycoprotein showed that epitopes within two domains, B and C, ...
5
Levels of Immunoglobulin Classes Are Not Associated with Severity of HIV Infection in Nigerian Patients
... of immunoglobulin concentration in predicting CD4+ cell count may appear limited on its own, measuring levels in conjunction with other bio- chemical parameters (such as the serum albumin levels) may potentially ...
5
A computational model for the coordination of neural progenitor self renewal and differentiation through Hes1 dynamics
... distinct G1 arrest states, in early and late ...exact G1 period at which they initiate differentiation, although the role of Hes1 in this context has not been examined (Pauklin and Vallier, ...
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Assessment of Maternal and Fetal Outcomes Secondary to Symptomatic Urinary Tract Infection during Pregnancy
... This study showed that pregnant women had lower levels of immunoglobulin G, immunoglobulin M and immunoglobulin E in serum and urine as compared to nonpregnant women which was seen at th[r] ...
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