Implications of Nucleotide Mutations for M005 Protein Expression 190
GBM-associated mutations and altered protein expression are more common in young patients
... key mutations and increased expression of two biomarkers, TUBB3 and ALK, which also have a known role in nervous system ...GBM mutations in younger patients, with the sole exception of PTEN, offers ...
13
Mutations in Sensor 1 and Walker B in the Bovine Papillomavirus E1 Initiator Protein Mimic the Nucleotide-Bound State
... initiator protein based on the recent structural ...bind nucleotide represent the Walker B motif (D478 and D479) and Sensor 1 (N523), three residues that are in close proximity to each other and generally ...
8
Interpretation of Mutations, Expression, Copy Number in Somatic Breast Cancer: Implications for Metastasis and Chemotherapy
... 117 provided that the variant-containing experimental sample(s) show a statistically significant increase in the presence of either form of intron inclusion corroborating reads. Veridical is able to automatically process ...
362
Identification of single nucleotide non-coding driver mutations in cancer
... of expression quantitative trait loci (eQTL) and disease-associated ...non-coding mutations are not usually tested within full length regulatory elements (that can be up to several kilobases), which may be ...
11
Analysis of single nucleotide polymorphism in the promoter and protein expression of the chemokine Eotaxin 1 in colorectal cancer patients
... One SNP of the eotaxin-1 gene, -384A>G, has been showed to have a functional role in regulation of gene expression, and thus influences the eotaxin-1 synthesis. The presence of allele G is associated with higher ...
7
Original Article Clinical implications of β-catenin protein expression in breast cancer
... its expression appeared to increase as tumors progressed: histological stage I tumors had the lowest β-catenin protein expression levels, while stage III tumors had the ...Ki-67 expression ...
6
Unique Classes of Mutations in the Saccharomyces cerevisiae G-Protein Translation Elongation Factor 1A Suppress the Requirement for Guanine Nucleotide Exchange
... guanine nucleotide exchange factor of eEF1A, eEF1Ba, is essential for cell viability, recent studies showed that eEF1A is able to dissociate GDP without its GEF although with a 700-fold slower rate (P ittman et ...
13
Modeling Effects of Human Single Nucleotide Polymorphisms on Protein-Protein Interactions
... In general any substitution can lead to ionization changes. The above results indicate that amino acid substitutions cor- responding to nsSNPs not only change the binding energy but could also result in changes in the ...
11
MYH7 Gene Mutations in Dilated Cardiomyopathy Patients: About 190 Cases at the Institute of Cardiology, Abidjan
... The mutations reported were classified as (i) silent mutation for nucleotide change in MYH7 gene without amino acid change in beta-myosin protein sequence, (ii) missense mutation for ...
6
Expression of Hepatitis B Virus X Protein Does Not Alter the Accumulation of Spontaneous Mutations in Transgenic Mice
... and nucleotide-excision-medi- ated ...HBx expression on DNA repair pathways other than ...of mutations in- curred by mouse hepatocyte DNA under the conditions used for the present study was the ...
7
Variable cardiac myosin binding protein-C expression in the myofilaments due to MYBPC3 mutations in hypertrophic cardiomyopathy
... decreased expression of cMyBP-C at mRNA and protein level in MYBPC3 mut con firming previous observations ...of protein translation and degradation is present ...cell, protein translation and ...
5
Prognostic Implications of ER, PR and HER2/Neu Protein Expression in a Cohort of Breast Carcinoma
... Seneviratne Bimalka, Seneviratne Senali, Adikaram Lakna. Prognostic Implications of ER, PR and HER2/Neu Protein Expression in a Cohort of Breast Carcinoma. American Journal of Laboratory Medicine. ...
6
Protein Expression and Purification
... multidimensional protein purification strategy for the parallel production of the catalytic G-do- mains of KRas, Rac1 and RalB GTPases in the active ...fluorescent nucleotide exchange ...in protein ...
10
Nucleotide Polymorphism at the RpII215 Gene in Drosophila subobscura: Weak Selection on Synonymous Mutations
... synonymous mutations can be explained by neutral mutational ...preferred mutations segregate at significantly higher frequency than unpreferred mutations, suggesting the action of natural ...gene ...
8
The effect of single nucleotide polymorphisms and mutations on congenital thrombotic thrombocytopenic purpura phenotype
... ADAMTS13 expression between the mutation and mutation + SNPs either singly or in ...ADAMTS13 expression in conditioned media as analysed by ELISA in ...ADAMTS13 expression levels in conditioned media ...
211
Naturally Occurring Mutations Define a Novel Function of the Hepatitis B Virus Core Promoter in Core Protein Expression
... promoter mutations (C to T at nucleotide [nt] 1768 and T to A at nt 1770) result in enhanced viral encapsidation and ...these mutations leading to increased encapsidation is mediated through enhanced ...
11
Original Article Expression of mini chromosome maintenance protein 7 in esophageal carcinoma and clinical implications
... MCM7 expression level and clinical indexes was analyzed. The expression of MCM7 mRNA and protein was significantly elevated in tumor tissues compared to adjacent tissues (P < ...MCM7 ...
6
GOLPH2 protein expression as a novel tissue biomarker for prostate cancer: implications for tissue-based diagnostics
... this expression analysis was a striking difference in GOLPH2 expression in normal and neoplastic prostate ...GOLPH2 expression excelled by 1 scoring point, in 51 cases ...
33
Nucleotide sequence and expression of the capsid protein gene of feline calicivirus.
... determined from this analysis that the amino acid sequence derived from the nucleotide sequence of the FCV cDNA clones matches the amino acid sequence experimentally derived from purifie[r] ...
8
Nucleotide and protein databases
... - Links between nucleic an protein sequences records - Updates by NCBI staff and record status indication - Data validation and format consistency. - Overview of information from several[r] ...
59