In-Silico
ANTI BACTERIAL AND TOXICOLOGICAL ACTIVITY IN SILICO OF CINNAMOMUM CASSIA ESSENTIAL OIL
... In silico Analysis (Osiris): The prediction process of the biological effects executed by the Osiris software is based on a pre-computerized set of molecular fragments which give origin to the toxicity alerts, in ...
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Re thinking drug discovery: In silico method
... Insilico methods are the leading-edge potential tools for assessing ADME properties. These Machine learning methods have ability in allocating diverse structures and complex mechanisms, are appropriate for prediction of ...
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In Vivo Antihyperlipidemic Activity of Ethanolic Fruit Extract of Solanum Virginianum Linn. : In Silico Profiling of Some of its Isolated Constituents
... This is to certify that this dissertation work entitled “IN VIVO ANTIHYPERLIPIDEMIC ACTIVITY OF ETHANOLIC FRUIT EXTRACT OF Solanum virginianum LINN., AND IN SILICO PROFILING OF SOME OF ITS ISOLATED CONSTITUENTS” ...
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Insight into the LGP2 Helicase Domain – An in Silico Approach
... Abstract LGP2, a member of retinoic acid inducible gene–I like receptors (RLR), encoded by the gene DHX58 in human induces antiviral response against many RNA viruses. The LGP2 shares a considerable similarity to the ...
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In Silico medicine: Social, Technological and Symbolic Mediation
... . From the outset, potential medical applications were highlighted as motivations for investment in this area of technology development. From its first paragraph, the VPH White Paper published in 2005 presents itself as ...
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INHIBITION OF MYCOBACTERIAL GLYCOSYLTRANSFERASES WITH PHYTOCOMPOUNDS AN IN SILICO APPROACH
... The rapid development of computational tools remarkably helps in narrowing the gap between in vitro and in silico methods. Applications of these tools vary from genome sequencing to drug discovery. New medicines ...
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Flavanones: Potential antidengue targets in silico approach
... Flavanones are known to exhibit anti HIV [5], antimalarial [6], anticancer [7] and antibacterial [8] activities. Flavanones like rutin, fisetin are reported to exhibit antidengue activity [9]. Moreover flavones have ...
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Secretome proteomics reveals candidate non-invasive biomarkers of BRCA1 deficiency in breast cancer
... The applicability of our results from murine breast tumor models to human BRCA1-related breast cancer is well supported by several levels of evidence. Many BRCA1-deficient candidate proteins identified play a role in DNA ...
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Towards radiological diagnosis of abdominal adhesions based on motion signatures derived from sequences of cine-MRI images.
... This paper reports novel development and preliminary application of an image registration technique for diagnosis of abdominal adhesions imaged with cine-MRI (cMRI). Adhesions can severely compromise the movement and ...
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A BAC clone fingerprinting approach to the detection of human genome rearrangements
... To explore the utility of fingerprint-based rearrangement detection, we used computational simulations and fingerprinted a set of clones derived from the MCF7 breast tumor cell line for which ESP data were available ...
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The role of spatial variations of abiotic factors in mediating intratumour phenotypic heterogeneity
... Additional strengths of the present study are that the parameter values used to perform numerical simulations come from existing literature, and the outcomes of our formal analysis are characterised by broad structural ...
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The role of spatial variations of abiotic factors in mediating intratumour phenotypic heterogeneity
... in silico the role played by the spatial distribution of abiotic components of the tumour microenvironment in mediating phenotypic selection of cancer ...in silico multicellular tumour spheroid and on the ...
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X Linked Dominant Congenital Ptosis Cosegregating with an Interstitial Insertion of a Chromosome 1p21 3 Fragment into a Quasipalindromic Sequence in Xq27 1
... in silico search for homologous sequences common to the critical region of chromosome Xq (as defined by FISH) and the dupli- cated fragment of the DPYD gene near the breakpoint areas as defined by array ...in ...
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In silico analysis of the grapefruit sRNAome, transcriptome and gene regulation in response to CTV CDVd co infection
... To determine the biological role that sRNAs play during CTV-CDVd co-infection, all differentially expressed sRNAs were subjected to in silico target pre- diction. Only three sRNAs (one uncharacterised and two ...
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In Silico Analysis of the Protein Structure of Tumor Suppressor Genes in Humans
... In silico analysis of the protein structures of Rb, p53, BRAC1 and BRAC2 genes revealed a high percentage of α-Helix content of the secondary protein structures of the genes; which provides maximal hydrogen ...
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A stereospecific carboxyl esterase from Bacillus coagulans hosting nonlipase activity within a lipase like fold
... In silico docking studies on the BCE structure confirmed that IPG esters with small acyl chains (≤C6) were easily accommodated in the active site pocket, indicating that small conformational changes are necessary ...
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The Role of Frontline Leadership in Organizational Learning: Evidence from Incremental Business Process Improvement
... Rhesus macaques are a widely used animal model of human diseases and related im- mune responses. Fc receptors (FcRs) mediate the interaction between antibody molecules and innate killing mechanisms, consequently ...
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Aloe Vera as an Antagonist for TNF Alpha: In Silico Study
... Abstract:- Rheumatoid arthritis is a chronic inflammatory disease that affects multiple joints. Tumor necrosis factor (TNF-α) is believed to be the major culprit involved in the progression of inflammation. In the ...
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In Silico Modeling of C1 Metabolism
... in silico modeling of complex molecu- lar pathway ...In silico modeling of the individual and integrated C1 metabolism models enables the identification of the most sensitive parameters involved in the ...
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Improved Hybrid/GPU Algorithm for Solving Cardiac Electrophysiology Problems on Purkinje Networks
... High complexity of the network or ionic model will reflect on the computational costs. Currently, it is possible to solve the monodomain equation on the densest of PN within hours, as we will show. For single simulations ...
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