in vacuo
Photoexcitation of Adenosine 5'-Triphosphate Anions in Vacuo : Probing the Influence of Charge State on the UV Photophysics of Adenine
... However, while the photofragments observed following photoexcitation of the monoanionic species, [AMP*H]* to [ADP*H]* to [ATP*H]* are entirely consistent with statistical decay, an addit[r] ...
45
Rapid Discovery of Pyrido[3,4-d]pyrimidine Inhibitors of Monopolar Spindle Kinase 1 (MPS1) Using a Structure-Based Hybridization Approach.
... The combined organics were washed with water, brine, dried, concentrated in vacuo and purified by flash column chromatography (0 - 100% EtOAc in cyclohexane) to give the title. compoun[r] ...
7
Investigating the Structural Compaction of Biomolecules Upon Transition to the Gas-Phase Using ESI-TWIMS-MS
... flexible linker or hinge regions are susceptible to gas-phase collapse. To determine how linear, elongated molecules with- out any distinct linker regions behave upon transition to the gas phase, we studied the protein ...
8
Synthesis of macrolactam analogues of radicicol and their binding to heat shock protein Hsp90
... (16.99 mL, 97.55 mmol, 3.0 eq.) was added slowly and the reaction mixture was stirred for 30 min, before being allowed to warm to room temperature and stirred for a further 2 h. Saturated aqueous ammonium hydroxide ...
41
Preparation and compounds of (8 methoxynaphth 1 yl)diphenylphosphine
... 7 powdered sulfur (0.03 g, 0.927 mmol) was added in small batches at 0 o C. The mixture was stirred for ½ hour at 0 o C and another 2 hours at ambient temperature. The resulting cloudy solution was filtered, the solvent ...
13
P stereogenic wide bite angle diphosphine ligands
... was slowly added to a suspension of NaH (1.7 g, 70.87 mmol) in THF (20 mL) at 0 °C over 20 min. After 20 min at 0 °C, the reaction mixture was allowed to warm to r.t., where after it was stirred for an additional 2 h to ...
11
Phosphonomethyl Oligonucleotides as Backbone Modified Artificial Genetic Polymers
... trimethylsilylbromide (0.95 mL, 7.22 mmol) at room temperature, and the mixture was stirred overnight. The volatiles were removed under reduced pressure and co-evaporated three times with anhydrous methanol to leave a ...
85
1′ Benzyl 3 (2,6 dichlorophenyl) 1′′ methyl 4,4′′ diphenyloxazole 5(4H) spiro 3′ piperidine 5′ spiro 3′′ pyrrolidine 2′′ spiro 3′′′ 1H indole 2′′′(3′′′H),4′ dione benzene hemisolvate
... A mixture of 1-benzyl-3,5-dibenzylidenepiperidin-4-one (2 mmol), isatin (2 mmol) and sarcosine (2 mmol) was re¯uxed in methanol (80 ml) until the disappearance of the starting material, as evidenced by thin-layer ...
15
Application of copper(II)-mediated radical cross-dehydrogenative coupling to prepare spirocyclic oxindoles and to a formal total synthesis of Satavaptan
... To a stirred solution of (Z)-N-(4-methoxybenzyl)-7-oxo-N- phenylcyclohept-3-enecarboxamide 21e (0.122 g, 0.348 mmol) in acetone (2 mL) at 0 °C was added a solution of DMDO (0.06 M in acetone, 11.1 mL, 0.696 mmol). The ...
13
Trivalent Gd-DOTA reagents for modification of proteins
... added to a cooled (0 C), stirred solution of HATU (546 mg, 1.41 mmol), 6 (400 mg, 1.14 mmol), and 2-amino-3-(4 00 -nitrophenyl) propyl (2 0 -aminoethyl)amine trihydrochloride 9 (55 mg, 0.32 mmol) in DMF (6 mL). The ...
7
Mechanism of pharmacophore biosynthesis for epoxyketone proteasome inhibitors
... organic layer was dried MgSO4, solvent removed in vacuo and resulting residue purified by silica gel chromatography ethyl acetate to yield a mixture of diastereomers demonstrated to have[r] ...
176
Biotransformations with yeasts and their applications in organic synthesis
... The quenched reaction mixture was diluted with ethyl acetate, washed with 1M aqueous sodium carbonate, dried MgS04 and the solvent removed in vacuo.. The residue thus obtained was azeotr[r] ...
182
Improving alkynyl(aryl)iodonium salts: 2 anisyl as a superior aryl group
... added m-CPBA (70–75% purity, 1.22 g, 4.90 mmol, 1 equiv.) slowly over a period of 1 hour. The resulting solution was slowly warmed to room temperature and stirred for 24 h after which it was reduced to half volume ...
7
Synthesis of Different Heterocyclic Compounds of Pharmaceutical Relevance
... Meerwein’s reagent (878 mg, 5.94 mmol, 1.2 eq.) was added in one portion to pyrrolidine-2- thione (500 mg, 4.95 mmol, 1 eq) in anhydrous DCM (10 ml) and the mixture was stirred for 1 hour at ambient temperature under an ...
298
Synthesis of Diazepine fused Porphyrinoids and Annulated Porphyrin Arrays
... mmol,) and N,N-dicyclohexylmethylamine (0.32 mL, 0.15 mmol) were added, and the flask was sealed and the mixture stirred at 120 °C for 24 h in the dark. The solvent was evaporated under reduced pressure and the crude ...
21
Alternative Methods for Analysis of Cyanobacterial Populations in Drinking Water Supplies: Fluorometric and Toxicological Applications Using Phycocyanin
... Cyanobacteria have gained attention from professionals and the public in light of the biotoxins they produce. Regulatory agencies responsible for recreational and drinking water supplies can utilize contact and/or ...
22
The difluoromethylene (CF2) group in aliphatic chains : synthesis and conformational preference of palmitic acids and nonadecane containing CF2 groups
... S10 18 h at rt. The reaction was quenched with water (102 mL) and EtOAc (102 mL). The precipitated white solid was filtered and the filtrate collected. The organic layer was separated and washed with water (2 × 102 mL) ...
45
Synthesis and Characterisation of Polystyrene Supported Chelating Ligands and their Transition and Inner Transition Metal Complexes
... The polystyrene-anchored Schiff base(PS- LH 2 ) (0.5.g) was suspended in DMF (20.ml) for 45 min. To this suspension, a DMF solution of appropriate metal salt was added. The mixture was refluxed for 8h with magnetic ...
7
(+)-Desoxoprosopinine: A Model for the Total Asymmetric Synthesis of Prosopis Alkaloids
... dropwise. This solution was allowed to stir at –30 o C for 1 h, and then was cooled to –78 o C. Through a double-tipped stainless steel needle, surrounded by a layer of dry ice, the cuprate solution was slowly ...
98
Cationic lipids and investigations into non-viral gene delivery systems
... extract was dried (magnesium sulfate) and concentrated in vacuo. Further[r] ...
267