INDOLIN-2-ONE
![(Z) 5 Fluoro 3 [(1H pyrrol 2 yl)methylene]indolin 2 one](data:image/gif;base64,R0lGODlhAQABAIAAAP///wAAACH5BAEAAAAALAAAAAABAAEAAAICRAEAOw==)
(Z) 5 Fluoro 3 [(1H pyrrol 2 yl)methylene]indolin 2 one
... bond length C – Cl 1.736 (5) Å, the C – F is 1.364 (2) Å in the current structure, similar to other indolin-2-one compounds (Ali, et al., 2008; De, 2008; Zhang, et al., 2008;) which contain ...
6
Microwave-assisted Synthesis, Characterization, Antimicrobial and Antioxidant Activities of 1-Benzyl-3-[(4-Methylphenyl)Imino]-Indolin-2-One and Its Co(II) Complex
... Microwave irradiation technique has been successfully developed for the synthesis of 1- Benzyl-3-[(4-methylphenyl)imino]-indolin-2-one (L) and its Co(II) complex. The in-vitro antibacterial ...
12
5′ Chlorospiro[1,3 dioxolane 2,3′ indolin] 2′ one: a potential anticonvulsant
... Anti-epileptic drugs have diverse chemical structures and complex physiological and pharmacological actions. The search for potential drugs and their mechanism of action has been difficult because of their complexity. A ...
7
Crystal structure of 3 {5 [3 (4 fluorophenyl) 1 isopropyl 1H indol 2 yl] 1H pyrazol 1 yl}indolin 2 one ethanol monosolvate
... The asymmetric unit of the title compound (Fig. 1) comprises of a 3-{5-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-1H- pyrazol-1-yl}indolin-2-one and an ethanol solvent molecule. The ...
12
(3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one attenuates hyperglycemia, increased hepatic glycogen content and hepatic damage induced by malathion acute exposure in rats
... grade. (3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one (OX- IME) was synthesized at the School of Chemistry and Food of Federal University of Rio Grande (FURG), RS, Brazil as described [31]. For this, an ...
9
Crystal structure of 6 chloro 5 (2 chloroethyl) 3 (propan 2 ylidene)indolin 2 one
... idene)indolin-2-one core with a Cl atom and a chloroethyl substituent attached to the aromatic ring. Two atoms of the aromatic ring and the chloroethyl substituent atoms are disordered over two sets ...
9
(E) 5 Chloro 3 (2,6 dichlorobenzylidene)indolin 2 one
... essentially in the plane of the indole ring. The indolyl plane with that of phenyl are twisted, with the dihedral angles between the rings are 62.16 (10), 63.06 (6)°, respectively, for each independent molecule. It's ...
9
6a Nitro 6 phenyl 6,6a,6b,7,8,9,10,12a octahydrospiro[chromeno[3,4 a]indolizine 12,3′ indolin] 2′ one
... The other pyrrolidine ring (N3/C21/C22/C27/C28) makes a dihedral angle of 39.60 (9)° with the pyran ring, it makes a dihedral angle of 88.12 (9)° with the piperidine ring which shows that they are almost at right angles ...
10
6 (4 Methoxyphenyl) 6a nitro 6,6a,6b,7,8,9,10,12a octahydrospiro[chromeno[3,4 a]indolizine 12,3′ indolin] 2′ one
... C1 0.128 (2) 0.0676 (13) 0.0613 (12) −0.0123 (13) −0.0229 (13) −0.0090 (10) C2 0.0710 (11) 0.0486 (9) 0.0556 (10) −0.0075 (8) −0.0074 (8) −0.0206 (7) C3 0.0848 (13) 0.0505 (9) 0.0519 (9) −0.0195 (9) 0.0094 (9) ...
11
2 Methyl 4 (naphthalen 2 yl) 3a nitro 3,3a,4,9b tetrahydro 2H spiro[chromeno[3,4 c]pyrrole 1,3′ indolin] 2′ one
... 4H-chromenes are biologically important compounds used as synthetic ligands in the design of drugs and discovery processes. They exhibit numerous biological and pharmacological properties, such as anti-viral, ...
11
1′ Allyl 1 (3,4 dimethylbenzoyl) 2 (4 methyl 1,3 thiazol 5 yl) 1,2,5,6,7,7a hexahydrospiro[pyrrolizine 3,3′ indolin] 2′ one
... C1 0.0442 (10) 0.0379 (10) 0.0324 (10) −0.0008 (8) 0.0013 (8) 0.0026 (8) C2 0.0567 (12) 0.0521 (13) 0.0457 (12) 0.0046 (10) −0.0018 (10) 0.0158 (10) C3 0.0466 (12) 0.0744 (16) 0.0514 (13) 0.0104 (11) −0.0084 (10) 0.0065 ...
11
1 [1 (trans 4 Isopropylcyclohexyl)piperidin 4 yl]indolin 2 one, one of a novel series of nociceptin receptor ligands
... Ligands in this series were synthesized by reductive amination of the appropriate aldehyde or ketone with the common intermediate N-1- (4-piperidinyl)-1,3-dihydroindol-2-one (Zaveri et al., 2004). Suitable ...
7
Crystal structure of 1′ (prop 2 yn 1 yl) 1,4 dihydrospiro[benzo[d][1,3]oxazine 2,3′ indolin] 2′ one
... Data collection: APEX2 Bruker, 2008; cell refinement: SAINT Bruker, 2008; data reduction: SAINT; programs used to solve.. AaminaNaaz et al...[r] ...
9
A COMPARATIVE GROUP QSAR AND MOLECULAR DOCKING STUDIES OF 4 THIAZOLIDINONE CONTAINING INDOLIN 2 ONE MOIETY AS VGEFR INHIBITORS
... It is a part of the system that restores the oxygen supply to tissues when blood circulation is inadequate 2, 3 . It is up regulated in cases of tumours. It acts as an essential growth factor and has important ...
10
1 (2,6 Dichlorophenyl)indolin 2 one
... of 2-(2-(2,6-dichloro- phenylamino)phenyl)acetate ...obtain 2-(2-(2,6-dichlorophenylamino)phenyl)acetic ...ethanol. 2-(2-(2,6-dichlorophenylamino)- phenyl)acetic acid ...
7
5 Amino 6 benzoyl 8 nitro 2,3 dihydro 1H spiro[imidazo[1,2 a]pyridine 7,3′ indolin] 2′ one dimethyl sulfoxide monosolvate
... intramolecular hydrogen bond with the benzoyl group, giving a S(6) motif. In the crystal, N—H O hydrogen bonds lead to the formation of chains along the c-axis direction. Within the chains there are further N—H O and C—H ...
11
Metal complexes of schiff base ligand 3-(((3-(2-hydroxyphenyl)-1-phenyl-1h-pyrazol-4-yl)methylene)hydrazono)indolin-2-one: preparation, characterization and biological studies
... All the complexes are coloured, stable, insoluble in water but soluble in organic solvents like DMF and DMSO. The complexes have characteristic colour (Zamir et al., 2015). The molar conductance of metal complexes was ...
8
Crystal structure, Hirshfeld analysis and molecular docking with the vascular endothelial growth factor receptor 2 of (3Z) 5 fluoro 3 (hydroxyimino)indolin 2 one
... For a lock-and-key supramolecular analysis, a molecular docking evaluation between the title compound and the vascular endothelial growth factor receptor-2 (VEGFR-2) was carried out. Initially, the ...
10
1 [1 (Decahydronaphthalen 1 yl)piperidin 4 yl]indolin 2 one: one of a novel series of nociceptin receptor ligands:
... C21 0.156 (3) 0.0800 (18) 0.0666 (17) 0.0029 (17) −0.0410 (17) 0.0009 (14) C22 0.094 (2) 0.0705 (15) 0.0695 (16) −0.0082 (12) −0.0293 (13) 0.0069 (12) C23 0.104 (2) 0.101 (2) 0.100 (2) −0.0165 ...
8
3 (2 Ethyl 2 phenylhydrazin 1 ylidene)indolin 2 one
... Data collection: SMART Bruker, 2000; cell refinement: SAINT Bruker, 2000; data reduction: SAINT; programs used to solve structure: SHELXS97 Sheldrick, 2008; programs used to refine struc[r] ...
8