Induced cardiac progenitor cells
Astragalus polysaccharides protect cardiac stem and progenitor cells by the inhibition of oxidative stress-mediated apoptosis in diabetic hearts
... diabetic hearts, preserving cardiac homeostasis. Secondly, APS treatment was shown to decrease NT and 8-OH-dG in CSPCs from STZ-induced diabetic hearts, which indicated that APS administration could inhibit ...
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Bmi1 + cardiac progenitor cells contribute to myocardial repair following acute injury
... within the first week of postnatal life [17, 36, 37], primar- ily, by proliferation of pre-existing cardiomyocytes and not by putative population(s) of endogenous CPC [38, 39]. However, the ability to efficiently ...
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MicroRNA-363 negatively regulates the left ventricular determining transcription factor HAND1 in human embryonic stem cell-derived cardiomyocytes
... hESC-derived cardiac progenitor cells and functional CMs, a subset of differentially expressed cardiac miRNAs was identified, and in silico analysis predicted highly conserved binding sites in ...
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Induced pluripotent stem cell-derived endothelial progenitor cells attenuate ischemic acute kidney injury and cardiac dysfunction
... Our echocardiography data indicated that iEPC therapy exhibited a protective effect against AKI-induced cardiac dysfunction. We did not observe any GFP-iEPCs in mouse hearts, suggesting that the possibility ...
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Transplantation of Isl1+ cardiac progenitor cells in small intestinal submucosa improves infarcted heart function
... To further determine the therapeutic effect of SIS- ECM-CPC transplantation, we examined the expression of heart failure markers associated with LV systolic dys- function (Fig. 6). The results of real-time PCR showed ...
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ANGPTL8 reverses established adriamycin cardiomyopathy by stimulating adult cardiac progenitor cells
... stem cells, respectively, and the binding of ANGPTLs to these receptors supported ex vivo expansion of hematopoietic stem ...leukemia cells, revealing that PirB supports leukemia ...stem cells and in ...
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Original Article Exercise-induced physiological hypertrophy initiates activation of cardiac progenitor cells
... The heart responses to the physiological stimu- li, such as exercise in a form called physiologi- cal hypertrophy [5, 6]. Unlike pathological hyp- ertrophy that ultimately decompensate to car- diovascular diseases such ...
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Disruption of histamine/H1R signaling pathway represses cardiac differentiation and maturation of human induced pluripotent stem cells
... differentiation, cardiac progenitor cell for- mation, and cardiac ...inducing cardiac differ- entiation mainly rely on the detailed mechanisms gov- erning heart development ...early ...
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ISL1 cardiovascular progenitor cells for cardiac repair after myocardial infarction
... in cardiac protection mediated by hISL1-CPC spheroids, we screened by quantitative PCR (qPCR) the mRNA expression of multiple candidate genes (Figure 10A and Supplemental Figure ...also induced the ...
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Transplantation of cardiac progenitor cells ameliorates cardiac dysfunction after myocardial infarction in mice
... Cardiac progenitor cells are a potential source of cell therapy for heart ...of cardiac stem/progenitor cells improves function of infarcted hearts, the pre- cise mechanisms of ...
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Single cell mechanical phenotype is an intrinsic marker of reprogramming and differentiation along the mouse neural lineage
... pluripotent cells in mixed ...of cells during reprogramming and the presence of various mechanical populations at the intermediate stages of reprogramming, cell stiffness could be a valuable label-free ...
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The epicardium as a source of multipotent adult cardiac progenitor cells: Their origin, role and fate
... limited, cardiac injury leads to the for- mation of scar tissue and thereby increases the risk of developing compensatory heart ...Epicardial cells undergo epithelial to mesenchymal transition (EMT), thus ...
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Mesodermal iPSC–derived progenitor cells functionally regenerate cardiac and skeletal muscle
... not cardiac, muscles is influenced by MiP myogenic ...MiP-injected cardiac and skeletal muscle 4 weeks after ...showed cardiac functionality that was significantly and comparably ameliorated by f- ...
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Stem Cell Sources for Regenerative Medicine and Cartilage Tissue Engineering.
... CD90+ cells are also found to positively correlate with chondrogenic potential in MSCs (Nagase et ...stromal cells (ADSCs) isolated from the same ...positive cells (Gimble et ...forming cells, ...
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Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model
... stem cells (naive, preconditioned, or genetically modified) have the ability to adopt a cardiomyocyte phenotype in vitro and in vivo [4, ...Stem cells are now being assessed as a therapeutic tool in the ...
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The curative effect of the associated cell transplantation on the rabbit myocardial infarction
... stem cells into cardiac muscle of female Yorkshire pigs whose left anterior de- scending had been ligated ...myocardial cells regenerated between the EPi layer and the Endo layer and the cells ...
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Catechins induced acute promyelocytic leukemia cell apoptosis and triggered PML-RARα oncoprotein degradation
... leukemia cells from the bone mar- row of three APL patients were enriched by Ficoll ...+ cells were purified from human cord blood by density gradient ...dye-excluding cells under light ...of ...
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Differentiation of human adipose-derived stem cells into cardiomyocyte-like cells in fibrin scaffold by a histone deacetylase inhibitor
... stem cells into cardiac cells need to be refined, since none of them couldn’t lead to the creation of functional cardiac cells ...for cardiac differentiation ...of cardiac ...
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A functional analysis of the role of SHP-2 in vertebrate heart development
... mutant cells derived from homozygous mutant embryos, show SHP-2 to be required for full and sustained activation of the MAPK pathway in response to FGF, thus demonstrating SHP-2 functions downstream of the ...
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Transplantation of human fetal pancreatic progenitor cells ameliorates renal injury in streptozotocin induced diabetic nephropathy
... creatic progenitor cannot be ruled out in this ...stem cells is ...mononuclear cells which briefly co-cultures with adherent cord blood-derived multipotent stem ...stem cells modulat- ing ...
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