Induced Hepatocarcinogenesis
Garlic Oil Attenuated Nitrosodiethylamine-Induced Hepatocarcinogenesis by Modulating the Metabolic Activation and Detoxification Enzymes
... ultimately result in oncogenesis [8-9]. NDEA is pri- marily metabolized to α-hydroxy derivative (ethyl-acet-oxyethyl-nitrosamine) by CYPs, especially CYP2E1. The intermediate could either be conjugated by phase I enzymes ...
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Implication of protein kinase R Gene quantification in hepatitis C Virus Genotype 4 induced Hepatocarcinogenesis
... PKR (protein kinase RNA-regulated) is a double stranded RNA (dsRNA) activated protein kinase that activates cellular apoptosis pathways [15-17]. PKR is present in a latent or inactive state in cells and is acti- vated by ...
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“The Potential Chemopreventive Efficacy of β-ionone against Diethylnitrosamine-induced Hepatocarcinogenesis in Male Wistar Rats” by Mohamed Abd-Elbaset, Ahmed M. Mansour, Amira M. Abo-Youssef, Egypt.
... Oxidative stress plays a crucial role in hepatocellular carcinoma (HCC) pathogenesis. HCC was associated with increased lipid peroxidation (LPO) resulting in disturbance of the equilibrium between the production of ...
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Effect of a homeopathic drug, Chelidonium, in amelioration of p DAB induced hepatocarcinogenesis in mice
... In the homeopathic mode of treatment, various micro doses (potencies) of Chelidonium herb extract are rou- tinely used against several forms of liver disorders, includ- ing liver cancer [6] with good effect. But, to our ...
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HINOKITIOL AMELIORATED DIETHYLNITROSAMINE INDUCED HEPATOCARCINOGENESIS THROUGH ANTIOXIDANT MECHANISM IN RATS: IN VITRO AND IN VIVO STUDY
... N-Nitrosodiethylamine displayed as important environmental carcinogen in N-Nitrosamine classification, and it induces the liver cancer by damaging the DNA of hepatocytes [5]. Hence, the nitrosoamines influence the role ...
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EVI1 promotes cell proliferation in HBx-induced hepatocarcinogenesis as a critical transcription factor regulating lncRNAs
... HBx-induced hepatocarcinogenesis acting as an oncogene, and the inhibition expression of EVI1 can suppress cell proliferation of HCC in vitro and in ...
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Gene modulation during peroxisome proliferator-induced hepatocarcinogenesis
... cyclosporin-induced hepatocarcinogenesis is not some proliferator-activated receptor α may mediate known, but it is possible that cyclophilin-mediated regulation of PP-induced alterations in ...
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Chemopreventive and Antioxidant Activity of Cichorium Intybus Leaves against Ndea Induced Hepatocarcinogenesis in Wistar Rats
... ethyl deoxy thymidine in liver which are responsible for its carcinogenic effects (Verna et al., 1996). It is also reported that the generation of reactive oxygen species (ROS) by NDEA causes carcinogenic effects. ...
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Protective Potential of Bioflavonoid: Hesperidin against Diethylnitrosamine Induced Hepatocarcinogenesis in Rats
... China. Hepatocarcinogenesis is a multistage process, normally resulting in a highly malignant tumour; however, progressive growth of hepatocytes from their normal state to malignancy is not clear ...
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Chronic liver inflammation modifies DNA methylation at the precancerous stage of murine hepatocarcinogenesis
... at the age of 12 months compared to the age of 9 months. The absence of this age-dependent hypomethylation in the Mdr2-KO liver could be explained by an age- dependent active demethylation of these CGIs in the control, ...
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COMPARISON BETWEEN THE EFFECT OF SOYBEAN AND GOATS MILK ON TUMOR-MARKER ENZYME ACTIVITIES DURING HEPATOCARCINOGENESIS IN RATS
... The optimum approach to conquering cancer is prevention. Although human diet contains components which promote cancer, it also contains components which may prevent it (2). Observations from animal studies have shown ...
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Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress
... is induced in response to chemical (DEN treatment) and genetic-induced hepatocarcinogenesis (disruptions in LKB1, p53, MST1/2, SAV1 and ...also induced in response to loss of liver mass due to ...
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SKP2 cooperates with N-Ras or AKT to induce liver tumor development in mice
... SKP2-associated hepatocarcinogenesis, we found a strong activation of the AKT/mTOR and Ras/ MAPK cascades in preneoplastic and neoplastic lesions from SKP2/N-RasV12 and SKP2/myr-AKT1 ...AKT-induced ...
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Distinct anti-oncogenic effect of various microRNAs in different mouse models of liver cancer
... along hepatocarcinogenesis remains largely ...tumors induced in mice by c-Myc overexpression or AKT/Ras co-expression exhibit distinct miRNA expression ...affects hepatocarcinogenesis depending on ...
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The chemopreventive effect of Ginkgo biloba and Silybum marianum extracts on hepatocarcinogenesis in rats
... tumors including HCC which is a typical hypervascular tumor [45]. Data in the present study showed that the serum VEGF level in NDEA treated rats was signifi- cantly elevated compared to the normal healthy rats. Liu et ...
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Mechanisms by which obesity accelerates hepatocarcinogenesis: molecular studies in foz/foz mice
... Chapter 3 HCC is accelerated in mice genetically predisposed to obesity and diabete s 111 Adiponectin is produced by white and brown adipose tissue. Unlike leptin, serum adiponectin levels are reduced in obese, diabetic ...
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Proton-Induced X-ray Emission (PIXE) Analysis and DNA-chain Break study in rat hepatocarcinogenesis: A possible chemopreventive role by combined supplementation of vanadium and beta-carotene
... Proton induced X-ray emission (PIXE) analysis was studied during a necrogenic dose (200 mg/kg of body weight) of Diethyl Nitrosamine (DENA) induced rat liver ...
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Re evaluation of the carcinogenic significance of hepatitis B virus integration in hepatocarcinogenesis
... in hepatocarcinogenesis, a systematic comparative study of both tumor and their corresponding non-tumor derived tissue has been conducted in a cohort of 60 HBV associated hepatocellular carcinoma (HCC) ...
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Atg9b Deficiency Suppresses Autophagy and Potentiates Endoplasmic Reticulum Stress-Associated Hepatocyte Apoptosis in Hepatocarcinogenesis
... during hepatocarcinogenesis, microarray study was conducted to analyse the differential expression of hepatic murine microRNAs (miRNAs) that may regulate broad biological processes in ...
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Mouse models of hepatocarcinogenesis: What can we learn for the prevention of human hepatocellular carcinoma?
... subunits, IKK1 (IKKa) and IKK2 (IKKb), as well as a regulatory subunit called NEMO (IKKg). Upon activation of this pathway by TNF, the IKK complex is recruited to adaptor proteins like TRAF2 and RIP1 and is activated by ...
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