Induced pluripotent
Generation of induced pluripotent stem cells from large domestic animals
... iPSCs: Induced pluripotent stem cells; OSKM: Oct4, Sox2, KFL4, and c-Myc; biPSCs: Bovine induced pluripotent stem cells; miPSCs: Mouse induced pluripotent stem cells; eiPSCs: ...
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Induced pluripotent stem cells: An update
... become pluripotent increased the enormous interest in induced pluripotent stem cell (iPsc) technology for their potential application in biomedical ...of pluripotent status in somatic cells by ...
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Role of tumor suppressor genes in the cancer-associated reprogramming of human induced pluripotent stem cells
... their pluripotent characteristics, human induced pluripotent stem cells (iPSCs) possess great potential for therapeutic application and for the study of degenerative ...exogenous pluripotent ...
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Induced pluripotent stem cells in the study of neurological diseases
... Five years after their initial derivation from mouse somatic cells, induced pluripotent stem (iPS) cells are an important tool for the study of neurological diseases. By off ering an unlimited source of ...
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Pluripotency of induced pluripotent stem cells
... into induced pluripotent stem (iPS) cells by the ectopic expression of four transcription factors that are highly expressed in embryonic stem (ES) ...
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Mouse induced pluripotent stem cells
... (MEFs) by retrovirus-mediated transfection and these cells were subsequently cultured on ES cell medium containing G418. While no drug-resistant colonies were observed following introduction of any single factor, a ...
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Induced pluripotent stem cells in infections
... of induced pluripotent stem cells (iPSCs) in differentiating into any type of cell in the human system we extrapolate the application of the iPSC technology to give rise to more lineage specific cells ...
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The potential and limitations of induced pluripotent stem cells to achieve wound healing
... Wound healing is the physiologic response to a disruption in normal skin architecture and requires both spatial and temporal coordination of multiple cell types and cytokines. This complex process is prone to ...
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Experimental approaches for the generation of induced pluripotent stem cells
... culture- induced reprogramming [1], these procedures are tech- nically demanding and ineffi cient and therefore unlikely to become a common approach for producing patient- specifi c pluripotent ...of ...
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Exosomes Secreted from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Osteonecrosis of the Femoral Head by Promoting Angiogenesis
... human-induced pluripotent stem cell-derived mesenchymal stem cells (hiPS-MSC-Exos) could promote angiogenesis of ischemic tissue in limb ischemia and skin defects [17, ...
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Therapeutic effects of proteoliposomes on X-linked chronic granulomatous disease: proof of concept using macrophages differentiated from patient-specific induced pluripotent stem cells
... In this study, we optimized the production of recombinant proteoliposomes containing an active human cytochrome b 558 and we characterized their biophysical and biochemical properties. In addition, we evaluated its ...
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Cardiotoxicity evaluation using human embryonic stem cells and induced pluripotent stem cell-derived cardiomyocytes
... at 24 h post administration. On the other hand, high concentration (10 μmol/L) of haloperidol abolished the spontaneous beating of hESC-CMs and no self-recovery was observed during the investigation period. Calculation ...
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Induced pluripotent stem cells in medicine and biology
... the pluripotent cells of the embryo. The recently developed induced pluripotent stem cell (iPSC) technology, which enables the induction of pluripotency in mature somatic cells by treatment with ...
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The Induced Pluripotent Cell: Development & Clinical Applications
... produce pluripotent cells without the use of oocytes and, most importantly, without the use of ...create pluripotent cells from previously differentiated ...in pluripotent cells (Tokuzawa, et ...as ...
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Biomedical Applications of Induced Pluripotent Stem Cells
... Takahashi and Yamanaka in 2006 ,discovered that somatic mouse fibroblasts could be reprogrammed into ESC-like colonies by the introduction of four transcription factors: Oct 3/4 , Sox2, Klf4 and c-Myc which are called ...
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Use Of Induced Pluripotent Stem Cell Models To Elucidate Retinal Disease Pathogenesis And To Develop Gene-Based Therapies
... of induced pluripotent stem cell-derived models of retinal pigment epithelium (iPSC- RPE) to study disease pathogenesis and a potential gene-based intervention in four different genetically distinct forms ...
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Generation of pig induced pluripotent stem cells using an extended pluripotent stem cell culture system
... Human induced pluripotent stem (iPS) cells hold great therapeutic promise for regenerative medicine. Human iPS cells can proliferate indefinitely in culture and differ- entiate into all cell types in an ...
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Induced Pluripotent Stem Cells: History, Properties and Potential Applications
... as induced pluripotent stem cells (iPSCs) have been shown to be greatly similar to the embryonic stem cells ...unique pluripotent property has placed them as the most suitable candidate for clinical ...
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Disruption of histamine/H1R signaling pathway represses cardiac differentiation and maturation of human induced pluripotent stem cells
... using pluripotent stem cell-derived CMs, including both hu- man embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), is propitious due to the similarities with human ...
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Transplantation of induced pluripotent stem cell-derived mesenchymal stem cells improved erectile dysfunction induced by cavernous nerve injury
... Induced pluripotent stem cells (iPSC) are pluripotent stem cells generated by reprogramming somatic cells ...(induced pluripotent stem cell-derived mesenchymal stem cells, iMSC), ...
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