induced pluripotent stem
Pluripotency of induced pluripotent stem cells
... into induced pluripotent stem (iPS) cells by the ectopic expression of four transcription factors that are highly expressed in embryonic stem (ES) ...
7
Induced pluripotent stem cells: An update
... iPSCs. Induced pluripotent stem cells (iPSCs) have become important cell sources for genetic disease models, and they have the potential to be cell sources for future clinical ...
8
Generation of induced pluripotent stem cells from large domestic animals
... iPSCs: Induced pluripotent stem cells; OSKM: Oct4, Sox2, KFL4, and c-Myc; biPSCs: Bovine induced pluripotent stem cells; miPSCs: Mouse induced pluripotent ...
12
Disruption of histamine/H1R signaling pathway represses cardiac differentiation and maturation of human induced pluripotent stem cells
... using pluripotent stem cell-derived CMs, including both hu- man embryonic stem cells (hESCs) and human induced pluripotent stem cells (hiPSCs), is propitious due to the ...
20
Mouse induced pluripotent stem cells
... (MEFs) by retrovirus-mediated transfection and these cells were subsequently cultured on ES cell medium containing G418. While no drug-resistant colonies were observed following introduction of any single factor, a ...
9
Induced pluripotent stem cells in infections
... of induced pluripotent stem cells (iPSCs) in differentiating into any type of cell in the human system we extrapolate the application of the iPSC technology to give rise to more lineage specific ...
5
The potential and limitations of induced pluripotent stem cells to achieve wound healing
... therapies. Stem cell therapy is emerging as a potential treatment for chronic wounds, and adult-derived stem cells are currently employed in several commercially available products; however, stem ...
10
Exosomes Secreted from Human-Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Prevent Osteonecrosis of the Femoral Head by Promoting Angiogenesis
... human-induced pluripotent stem cell-derived mesenchymal stem cells (hiPS-MSC-Exos) could promote angiogenesis of ischemic tissue in limb ischemia and skin defects [17, ...and stem cells ...
13
Transplantation of induced pluripotent stem cell-derived mesenchymal stem cells improved erectile dysfunction induced by cavernous nerve injury
... Induced pluripotent stem cells (iPSC) are pluripotent stem cells generated by reprogramming somatic cells ...(induced pluripotent stem cell-derived mesenchymal ...
15
Role of tumor suppressor genes in the cancer-associated reprogramming of human induced pluripotent stem cells
... their pluripotent characteristics, human induced pluripotent stem cells (iPSCs) possess great potential for therapeutic application and for the study of degenerative ...multipotent stem ...
9
Induced Pluripotent Stem Cells: History, Properties and Potential Applications
... of induced pluripotent stem cells (iPSCs) has been met with much enthusiasm and hailed as a breakthrough discovery by the scientific and research communities amidst the divisive and ongoing debates ...
6
Induced pluripotent stem cells: advances to applications
... Abstract: Induced pluripotent stem cell (iPS) technology has enriched the armamentarium of regenerative medicine by introducing autologous pluripotent progenitor pools bioengineered from ...
9
Manifestation of Huntington’s disease pathology in human induced pluripotent stem cell-derived neurons
... human pluripotent stem cells (PSCs), have jointly engendered new disease models based on induced PSCs (iPSCs) derived from the som- atic cells of patients with particular afflictions [9, ...
15
Cardiotoxicity evaluation using human embryonic stem cells and induced pluripotent stem cell-derived cardiomyocytes
... Cardiac toxicity remains a major cause of restriction or withdrawal of drugs from the market [1]. Between 1990 and 2001, eight non-cardiovascular drugs were with- drawn at an estimated cost of $12 billion due to drug- ...
7
DeepNEU: cellular reprogramming comes of age – a machine learning platform with application to rare diseases research
... expressed pluripotent transcription factors and the efficiency of inducting protocols for PSCs [18, ...artificially-induced pluripotent stem cells (aiPSCs), artificially-induced neural ...
13
BMP4 directed trophoblast differentiation of human embryonic stem cells is mediated through a ΔNp63+ cytotrophoblast stem cell state
... human pluripotent stem cells (hPSCs), including embryonic (hESCs) and induced pluripotent stem cells (hiPSCs), as useful models for trophoblast differentiation; specifically, in the ...
12
Understanding Regenerative Medicine and Its Position in Healthcare
... heal. Induced pluripotent stem cells will likely focus more on disease treatment while embryonic stem cells will concentrate on debilitating injuries and degenerative disorders (Hanley, ...
12
Stem cells: a model for screening, discovery and development of drugs
... cancerous stem cells and the recent advances made in isolation and culture of stem cells have rapidly gained attention in the field of drug discovery and regenerative ...using stem cells offers a ...
9
Stem cell therapies for age-related macular degeneration: the past, present, and future
... required. Stem cells are able to differentiate into several cell types as well as self- ...into pluripotent stem cells (embryonic stem cells [ESCs] and induced pluripotent ...
10
Stem Cell Sources for Regenerative Medicine and Cartilage Tissue Engineering.
... The research described in this dissertation covers both induced pluripotent stem cells and adult tissue progenitors as clinical cell sources for regenerative medicine. We were able to derive canine ...
85