Induced pluripotent stem cell (iPSC)
Transplantation of induced pluripotent stem cell-derived mesenchymal stem cells improved erectile dysfunction induced by cavernous nerve injury
... Induced pluripotent stem cells (iPSC) are pluripotent stem cells generated by reprogramming somatic cells ...[22]. iPSC can differentiate into MSC (induced ...
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Integration of induced pluripotent stem cell-derived endothelial cells with polycaprolactone/gelatin-based electrospun scaffolds for enhanced therapeutic angiogenesis
... on iPSC-ECs in vivo, tracking cell survival and re- tention using non-invasive imaging of the luciferase cell ...of iPSC-ECs alone resulted in poor survival consistent with the weight of ...
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Generation of HLA-Universal iPSC-Derived Megakaryocytes and Platelets for Survival Under Refractoriness Conditions
... HLA-universal induced pluripotent stem cell (iPSC) line that can be used as a renewable cell source for the generation of low immunogenic cell ...HLA-universal iPSC ...
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Induced pluripotent stem cells in medicine and biology
... the pluripotent cells of the embryo. The recently developed induced pluripotent stem cell (iPSC) technology, which enables the induction of pluripotency in mature somatic cells ...
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Fast Adipogenesis Tracking System (FATS)—a robust, high-throughput, automation-ready adipogenesis quantification technique
... of stem cells, and therefore, its accurate measurement is ...large cell clumps or high cell ...various cell lines including 3T3-L1 cells, adipose- derived mesenchymal stem cells (ASCs), ...
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Human development, heredity and evolution
... embryonic stem cell (ESC) and induced pluripotent stem cell (iPSC) technology have enabled the generation of human organoids (miniature versions of human tissues and ...
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Histone Variant Macroh2a In The Gut And Beyond: A Study Of Intestinal Fortitude
... adult stem cell identity and function in ...use induced pluripotent stem cell (iPSC) reprogramming and the murine intestinal stem cell (ISC) system to model ...
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Down-regulation of ghrelin receptors on dopaminergic neurons in the substantia nigra contributes to Parkinson’s disease-like motor dysfunction
... PD-specific induced pluripotent stem cell (iPSC)-derived dopaminergic (DAnergic) neurons generated from patients carrying parkin gene (PARK2) mutations compared to those from healthy ...
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The secretome of induced pluripotent stem cells reduces lung fibrosis in part by hepatocyte growth factor
... [20]. Cell-free methods carrying a similar therapeutic potential could therefore offer an obvious advantage for a clinical translation in the ...of cell-conditioned media obtained from stem cells, ...
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The potential and limitations of induced pluripotent stem cells to achieve wound healing
... multiple cell types and ...therapies. Stem cell therapy is emerging as a potential treatment for chronic wounds, and adult-derived stem cells are currently employed in several commercially ...
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Directly induced human Schwann cell precursors as a valuable source of Schwann cells
... iSCPs: Induced-Schwann cell precursors; iSCs: iSCP-derived Schwann cells; iPSC: Induced pluripotent stem cells; hESCs: Human embryonic stem cells; NCSCs: Neural crest ...
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Induced pluripotent stem cells in infections
... therapeutic cell replacement purposes ...sickle cell mice, in which the mouse α-globin genes were replaced with the human sickle globin variants ...as cell-based therapy in various immune deficient ...
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Establishment of a complex skin structure via layered co-culture of keratinocytes and fibroblasts derived from induced pluripotent stem cells
... major cell types in the epidermal and dermal layers of skin, ...using iPSC-Ks and iPSC-Fs. iPSC-Fs were stratified in type I collagen and overlaid with ...seeding iPSC-Ks (day 9), the ...
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The immune response of stem cells in subretinal transplantation
... potential cell for grafting, immunogenicity has been extensively ...embryonic stem cells (ESCs) and their derivatives escaped host immune attack and survived for long pe- riods in animal ...dendritic ...
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Neuronal maturation reduces the type I IFN response to orthobunyavirus infection and leads to increased apoptosis of human neurons
... While well defined in immune cells, the type I IFN re- sponse to virus infection in human neural-lineage cells has not been well characterized. We found that CO neural progenitors, but not committed neurons have a robust ...
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ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration
... We next assessed whether this acidification deficit is asso- ciated with impaired degradation of endocytosed proteins. We analyzed ligand-induced degradation of epidermal growth factor receptor (EGFR) (38) using a ...
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Genetically Encoded Photoactuators and Photosensors for Characterization and Manipulation of Pluripotent Stem Cells
... Inhibition of cell excitability via membrane hyperpolarization has traditionally been achieved using either light-gated inward chloride pumps (halorhodopsin, HR; Fig. 1) [35] or light-gated outward proton pumps ...
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Genome-wide interaction target profiling reveals a novel Peblr20-eRNA activation pathway to control stem cell pluripotency
... to transcribe eRNAs. Kim et al [67] estimated that only about half of the intergenic enhancers can transcribe eRNAs. Enhancer transcription is a widespread phenomenon observed across multiple cell types in ...
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Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome
... shown, iPSC lines were validated and the stages of neural differentiation in vitro were carefully characterized using a variety of immunocy- tochemical, physiological, and molecular assays, including Fluidigm ...
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C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+ permeable AMPA receptor mediated excitotoxicity
... performed by submerging slides in BaseScope 1 × target retrieval reagent at 99 °C in a Braun Multiquick FS 20 steamer for 15 min. The tissue was then permeabilised using BaseScope protease III at 40 °C for 30 min. Probe ...
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