inducible vascular factor 3
Hepatitis C Virus Stabilizes Hypoxia-Inducible Factor 1α and Stimulates the Synthesis of Vascular Endothelial Growth Factor
... The expression of HIF-1 ␣ plays important roles in angio- genesis, tumor growth, invasion, and metastasis (24, 48). Up- regulation of HIF-1 ␣ has been observed in a broad range of cancers, including cancers of the brain, ...
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Hypoxia inducible factor 1α and vascular endothelial growth factor expression in circulating tumor cells of breast cancer patients
... growth factor expression in breast cancer cell lines and in circulating tumor ...2:T47D, 3: SKBR3 4:MDA MB-453, 5: MDA MB-231 (western blot analysis of equal protein amount of cell ...
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Expression of hypoxia-inducible factor-1α and vascular density in mammary adenomas and adenocarcinomas in bitches
... Growth Factor Receptor 2), with mediation of phosphatidylinositol-3-kinase (PI3K), serine/threonine kinases (AKT) and mammalian target for rapamycin (mTOR) ...a factor, which allows the cells to ...
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Normalization of Tumor Vasculature by Oxygen Microbubbles with Ultrasound
... tumor vascular normalization (VN), which inhibits angiogenesis to improve vessel maturity, blood perfusion, and oxygenation, has been demonstrated under the anti-angiogenic ...hypoxia inducible ...
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Hepatoprotective Activities of the Methanol Extract of Angelica shikokiana and Isoepoxypteryxin against Hepatocellular Carcinoma
... to the best of our knowledge, there is no previous report about either the hepatoprotective activity of A. shikokiana or isoepoxypteryxin against HCC or their possible mechanisms of the activity. So, this study was ...
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Original Article Specific silencing of hypoxia inducible factor-1α, hypoxia inducible factor-2α and hypoxia inducible factor-1β by small interference RNA reduces the expression of vascular endothelial growth factor in BGC-823 gastric cancer cells under hypoxia
... ried out. These results showed that HIF-1α pro- tein expression in normoxia group was very low, but it was increased at 2, 4 and 8 h after hypox- ia, reaching a peak at 4 h (P < 0.05). However, HIF-1α protein ...
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A Correlative Study between CT Perfusion Parameters and Angiogenesis in Rabbit VX2 Liver Tumors
... Hypoxia-inducible factor-1 alpha (HIF-1 α ) is the key regulator of an- giogenesis in hypoxia, which directly and indirectly affects angiogenesis by influencing the expression of other angiogenic growth ...
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Original Article Expression of vascular endothelial growth factor and hypoxia-inducible factor 1α in rat traumatic lung injury
... Trauma shows a trend of increase year by year with social development. Trauma has become an important factor of death, while the inci- dence of chest trauma caused by traffic acci- dents was as high as 40% [1, 2]. ...
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Hypoxia-inducible factor-1 α/platelet derived growth factor axis in HIV-associated pulmonary vascular remodeling
... pulmonary vascular bed [4-7], popular hypothesis is that secretary HIV-1 viral proteins in circulation are capable of indu- cing vascular oxidative stress and direct endothelial cell dysfunction and smooth ...
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The prolyl hydroxylase enzymes are positively associated with hypoxia inducible factor 1α and vascular endothelial growth factor in human breast cancer and alter in response to primary systemic treatment with epirubicin and tamoxifen
... Relationship between tumours expressing PHD1, PHD2 and PHD3 at baseline and clinicopathologic variables PHD1 was expressed in 47/176 (26.7%) tumours, PHD2 in 85/163 (52.2%) tumours and PHD3 in 69/177 (39%) tumours at ...
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Effect of low level laser irradiation (llli) on expression of vascular endothelial growth factor (vegf) and inducible nitric oxide synthase (inos) in rats model of myocardial infarction
... Method: 110 SD rats were randomly divided into Sham, control and treatment group. Control and treatme group established rat model of myocardial infarction (RMMI) by ligation of left anterior descending artery while Sham ...
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Type H blood vessels in bone modeling and remodeling
... growth factor type BB (PDGF-BB), slit guidance ligand 3 (SLIT3), hypoxia-inducible factor 1-alpha (HIF-1α), Notch, and vascular endothelial growth factor (VEGF) are involved in ...
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Upregulated hypoxia inducible factor 1α and 2α pathway in rheumatoid arthritis and osteoarthritis
... increases vascular permeabil- ity [20], resulting in edema, protein leakage, and probably granulation tissue formation (pannus) with erosion of the articular cartilage and progressive destruction of the ...potent ...
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Expression of hypoxia inducible factor 1 alpha and its downstream targets in fibroepithelial tumors of the breast
... proteasome [2,3]. Hypoxia inhibits this process, resulting in upregulation of HIF-1 α and its downstream target genes [4]. On the other hand, hypoxia-independent upregulation of HIF- 1 α may be accomplished by loss of ...
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Further investigation into the roles of vascular endothelial growth factor and thymidine phosphorylase in urological malignancy
... on vascular endothelial cells although Flt-1 has been identified on ...the vascular abnormalities and intra-uterine death in knock out mice deficient for either Flt-1 or KDR (70, ...the vascular ...
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Vol 27, No 4 (2014)
... In parallel, most of the affected women are reproductive age individuals without significant comorbidities, desiring to preserve fertility or solve the problem of infertility. For this perspective, promising candidates ...
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Insilico Modeling of Vascular Endothelial Growth Factor and its Interaction with Inhibitor Terrein
... and vascular permeability observed in teeth with pulpitis may contribute to the development of therapeutic strategies designed to control these responses and prevent pulp ...
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Original Article Ginsenoside Rg3 inhibits HIF-1α and VEGF expression in patient with acute leukemia via inhibiting the activation of PI3K/Akt and ERK1/2 pathways
... hypoxia-inducible factor (HIF- 1α) activates the transcription of VEGF and other factors involved in tumor development ...phosphatidylinositol 3-kinase (PI3K)/AKT and mitogen-activated protein kinase ...
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Glioblastoma cancer stem cells: Basis for a functional hypothesis
... growth factor containing media and AC in serum con- dition in 10 and in 13 cases ...growth factor containing media NS grew and behaved like NSCs, with clonogenicity and tumorigenicity and with a gene ...
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Biomarkers Expression in Cervical Cancer and High Grade Squamous Intraepithelial Lesions
... poxia-inducible factor-1(HIF-1α), vascular endothelial growth factor (VEGF) and eritropoyetin receptor (EpoR) in cer- vix cancer stages IIA-IIB and in preinvasive high grade squamous ...
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