inflammasome activation
Silica-induced NLRP3 inflammasome activation in vitro and in rat lungs
... the inflammasome pathway in silica-induced lung inflammation and tissue remodel- ing has been emerging ...(NLRP3) inflammasome belongs to the NLR subfamily of pattern- recognition receptors ...the ...
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Evasion of inflammasome activation by microbial pathogens
... caspase-3 activation is an active process or a consequence of caspase-1 ...to activation of the innate immune ...of inflammasome activation by ExoS- and ExoU-containing ...
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Original Article Obeticholic acid improves hepatic steatosis and inflammation by inhibiting NLRP3 inflammasome activation
... NLRP3 inflammasome activation by down-regulating the expressions of NLRP3 and ...that activation of farnesoid X nuclear receptor could interfere with NLRP3 inflamma- some activation by ...
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Caffeine Inhibits NLRP3 Inflammasome Activation by Suppressing MAPK/NF-κB and A2aR Signaling in LPS-Induced THP-1 Macrophages
... Recent experiments have shown that treatment with A2aR antagonists either prevents or reverses the ability of inflammatory stimuli to activate human alveolar macrophages [31]. In addition, A2aR acts as a key regulator of ...
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Novel perspectives on non-canonical inflammasome activation
... Canonical inflammasome activation (canonical ...the inflammasome. (vi) This initiates cleavage and activation of pro-caspase-1, pro-IL-1β, and pro-IL-18, (vii) allowing secretion of IL-1β and ...
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Exposure to nickel oxide nanoparticles induces pulmonary inflammation through NLRP3 inflammasome activation in rats
... NLRP3 inflammasome is involved in NiONP- induced pulmonary inflammation and ...NLRP3 inflammasome activation requires particle uptake and reactive oxygen species ...NLRP3 inflammasome ...
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NLRC4 suppresses melanoma tumor progression independently of inflammasome activation
... ies highlight the role of AIM2, independent of the inflammasome, in suppression of colorectal cancer (45, 46). Man et al. showed that AIM2 played a role in suppressing aberrant proliferation of intestinal stem ...
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Medical Sciences The stimulation of inflammasome activation and modulation of proinflammatory cytokine production by house dust mite major allergen in patients with SLE
... The most prevalent and well-investigated indoor perpetual allergen source is House Dust Mites (HDM). HDM major allergen, Der p 2, can induce proinflammatory cytokine production which is conducted by NLRP3 ...
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TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy
... TNF/pyrin inflammasome axis, with TNF signaling and inflam- masome activation synergistically amplifying the inflammatory ...pyrin inflammasome–mediated IL-1β promotes TNF production to modulate ...
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Age-related increases in amyloid beta and membrane attack complex: evidence of inflammasome activation in the rodent eye
... mediate activation of the NLRP3 inflammasome [15, 16]. The inflammasome is a multi-protein complex that activates caspase-1 and pro- duces the pro-inflammatory cytokines IL-1β and IL-18, which in ...
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Inflammasome Activation Contributes to Interleukin 23 Production in Response to Clostridium difficile
... tive during challenge with toxins A and B (12) but pathogenic in an infection model (17). IL-1 is thought to play an essential role in the induction of CXCL1 and recruitment of neutrophils, which may be pathogenic ...
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Inflammasome Activation in Response to the Yersinia Type III Secretion System Requires Hyperinjection of Translocon Proteins YopB and YopD
... NLRP3 inflammasome activation, as mutations in the T3SS chaperone gene lcrH that do not affect YopE or YopM trans- location, but are not capable of forming pores in RBCs, are also incapable of triggering ...
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Original Article Inhibition of ER stress by 4-PBA protects MCT-induced pulmonary arterial hypertension via reducing NLRP3 inflammasome activation
... NLRP3 inflammasome activation and endoplasmic-reticulum (ER) stress contribute to the pathogenesis and development of pulmonary arterial hypertension ...NLRP3 inflammasome activation in ...
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Tenuigenin protects dopaminergic neurons from inflammation via suppressing NLRP3 inflammasome activation in microglia
... NLRP3 inflammasome is in- volved in the progression of PD [10, 11, 22, ...NLRP3 inflammasome-mediated IL-1 β production requires two ...inflammasome activation. The second signal directly ...
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Inflammasome Activation by Bacterial Outer Membrane Vesicles Requires Guanylate Binding Proteins
... caspase-11 activation in macrophages exposed to ...caspase-11 activation through ...inflammasome activation in response to purified OMVs added to macrophages ...pronounced activation of ...
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Shigella sonnei O Antigen Inhibits Internalization, Vacuole Escape, and Inflammasome Activation
... Once S. sonnei and S. flexneri cytosolic numbers were normalized, pyroptosis pro- ceeded via similar pathways and to similar levels. For both species, cell death was predominantly dependent on GSDMD and caspase-1, ...
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Original Article Activation of NLRP3 inflammasome in the ovaries during the development and treatment of polycystic ovary syndrome
... the activation of nucleotide leukin rich polypeptide 3 (NLRP3) inflammasome in the ovaries during the development and treatment of ...caspase-1 activation, and IL-1β production were unregulated, ...
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Tyrosine dephosphorylation of ASC modulates the activation of the NLRP3 and AIM2 inflammasomes
... FIGURE 1 | PAO inhibits NLRP3 inflammasome activation. THP-1 macrophages (A,C–E) and BMDMs (B,D) were primed with LPS (1 µg/ml) for 3 h followed by treatment with PAO (0.01–10 µM) or vehicle for 30 min. ...
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Activation and Evasion of the Inflammasome by Yersinia
... for inflammasome recognition of the T3SS as Yptb expresses an archetypal T3SS and is a genetically tractable, natural rodent ...inhibit inflammasome activation, until this work very little was known ...
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Inflammasomes and IL 1 biology in the pathogenesis of allograft dysfunction
... of inflammasome activation and IL-1 expression is the upregulation of adhesion molecules and chemokines, which leads to allograft neutrophil sequestration, mononuclear phagocyte recruitment, and T cell ...
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