INH resistance
Evolution of extensively drug resistant Mycobacterium tuberculosisfrom a susceptible ancestor in a single patient
... of INH and STR over time could be a cu- mulative effect of multiple ...the resistance to INH conferred by the katG frameshift ...in INH resistance or fitness ...KAN/AMK ...
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Comprehensive Whole Genome Sequencing and Reporting of Drug Resistance Profiles on Clinical Cases of Mycobacterium tuberculosis in New York State
... drug resistance profiles generated by WGS are being reported to physicians an average of 9 days earlier than first-line DST results and 32 days earlier than complete second-line DST ...detected resistance ...
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Isoniazid-Resistance Conferring Mutations in Mycobacterium tuberculosis KatG: Catalase, Peroxidase, and INH-NADH Adduct Formation Activities
... isoniazid resistance have been associated with point mutations, deletions, insertions, or complete loss of the KatG ...to INH-activation processes governed by either the heme cofactor ...of INH- ...
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Evaluation of a new automated Abbott RealTime MTB RIF/INH assay for qualitative detection of rifampicin/isoniazid resistance in pulmonary and extra-pulmonary clinical samples of <em>Mycobacterium tuberculosis</em>
... for resistance, using RealTime MTB INH/RIF (RT MTB ...RIF/ INH, and of the 27 samples that were resistant to RIF, Abbott RealTime MTB INH/RIF detected resistance mutations in 26 of ...
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Concordance between Molecular and Phenotypic Testing of Mycobacterium tuberculosis Complex Isolates for Resistance to Rifampin and Isoniazid in the United States
... drug resistance or were from patients believed to be at high risk for MDR ...were INH susceptible ...RMP resistance (to include the RRDR of rpoB), as well as INH resistance (to include ...
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Validation of the GenoType® MTBDRplus assay for detection of MDR TB in a public health laboratory in Thailand
... been validated as a rapid and reliable first-line diagnostic test on AFB-positive sputum or MTB isolates for INH resistance, RIF resistance, and MDR-TB in Bangkok, Thailand. Whether it should be ...
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Original Article Comparison of genotype MTBDR plus results between TB patients with different levels of drug resistance: a retrospective study in China
... drug resistance and the timely initiation of effective therapy are essential for treating and preventing transmission of ...of INH and RIF resistance in TB isolates with two different lev- els of ...
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Diversity and evolution of drug resistance mechanisms in <em>Mycobacterium tuberculosis</em>
... of resistance to multiple ...RIF resistance but intact katG, inhA, and oxyR-ahpC, indicating that efflux pumps, rather than mutations alone, were responsible for the INH ...and resistance to ...
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Genotypic detection of rifampicin and isoniazid resistant Mycobacterium tuberculosis strains by DNA sequencing: a randomized trial
... Direct sequencing of KatG gene revealed point mutation in 24/26 (92.3%) and the remaining 2/26 (7.7%) had wild type KatG (no evidence of mutation) with high sta- tistical significant difference between them (P < ...
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Treatment of isoniazid resistant pulmonary tuberculosis
... comprised INH, RIF, EMB, and PZA, which was strongly recommended by the National Tuberculosis Program [13- ...the INH- resistance of the isolated M. tuberculosis strains, INH treat- ment was ...
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Application of Deletion- Targeted Multiplex PCR technique for detection of Mycobacterium tuberculosis Beijing strains in samples from tuberculosis patients.
... for resistance to isoniazid (INH), and rifampin (RIF) by PCR using relevant ...to INH resistance and 20 ...RIF resistance, and 8 (5%) were detected as Beijing strain using multiplex ...
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Occurrence of disputed rpoB mutations among Mycobacterium tuberculosis isolates phenotypically susceptible to rifampicin in a country with a low incidence of multidrug resistant tuberculosis
... acquire resistance to additional drugs [34, ...itional resistance to SM and EMB and are more likely to cause unfavourable treatment outcome while inhA-RR mutations are mainly associated with additional ...
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Pilot Study of Isoniazid Acetylation in Melanesian Healthy Subject from Indonesia
... of INH and Ac-INH were identified by organoleptic observation and analyzed by using FTIR (Shimadzu 8400S, Kyoto, ...reacting INH and acetic anhydride over a water bath (Julabo TW20, Allentown, USA) ...
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Detection of Multidrug Resistance in Mycobacterium tuberculosis
... Drug resistance in ...drug resistance, including rpoB for rifampin (RIF), katG and the mabA (fabG1)-inhA promoter for isoniazid (INH), embB for ethambutol (EMB), pncA for pyrazinamide (PZA), rpsL and ...
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The effect of low growth temperature on Hill reaction and Photosystem 1 activities in three biotypes of Kochia scoparia (L ) Schrad with different sensitivity to atrazine and ALS inhibiting herbicides
... double resistance to both atrazine and acetolactate synthase (ALS) inhibitors (Bubny biotype), resistance to ALS inhibitors but not to atrazine (Jihlava biotype), or sensitivity to both types of herbicides ...
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Utility of Second Generation Line Probe Assay (Hain MTBDRplus) Directly on 2 Month Sputum Specimens for Monitoring Tuberculosis Treatment Response
... A strength of this study was that the same 2-month sputum specimen was utilized for carrying out both direct MTBDRplus testing and liquid culture. This reduced the variability associated with cough efforts and M. ...
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Primary drug resistance of mycobacterium tuberculosis in Shandong, China, 2004–2018
... Our study had enrolled 11,467 newly diagnosed TB cases with DST results at 36 TB surveillance centers across Shandong, China from 2004 to 2018 to evaluate the epi- demiology and high risk factors of primary TB drug re- ...
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Health-related quality of life of patients with multidrug-resistant tuberculosis in Yemen: prospective study
... HPA: Hypothalamic-Pituitary-Adrenal; HRQoL: Health-Related Quality of Life; INH: Isoniazid; IP: Initial Phase; MCS: Mental Component Summary; MDR: Multi-Drug Resistance; MH: Mental Healt[r] ...
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Diagnosing Drug Resistant Tuberculosis with the Xpert®MTB/RIF The Risk for Rifampin Susceptible Cases
... H resistance is remarkably prevalent globally ...H resistance is much higher than that of R, detection of H-resistance has received lower priority, largely because the clinical impact of H ...
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Susceptibility testing of slowly growing mycobacteria by a microdilution MIC method with 7H9 broth
... As previously noted, the current single-drug concentrations of INH and STR which are used in the proportion method usually do not allow one to distinguish primary drug resistance from ac[r] ...
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