inhibitory mechanism
Inhibition of human carboxylesterases by ginsenosides: structure–activity relationships and inhibitory mechanism
... Over the past decade, ginseng-related products have been widely used in combination with a variety of ther- apeutic drugs to treat various types of cancer in clinical settings. In addition to enhancing efficacy and ...
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Probing the Inhibitory Mechanism of Calcite Precipitation by Organic Phosphonates in Industrial Water Cooling System
... Moreover, Franca et al. have studied the adsorption of two phosphonate groups from different amine groups on barite crystal. It has been found that both stereochemical hindrance and complexation strength differences ...
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Inhibitory Mechanism of the CXCR4 Antagonist T22 against Human Immunodeficiency Virus Type 1 Infection
... In this study, we demonstrated that T22 inhibits replication of T-tropic strains of HIV-1, including primary isolates, but not of non-T-tropic strains in PHA-stimulated PBMC (Table 1). Viral determinants for T22 ...
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Neurophysiological correlates of the dopaminergic cilio inhibitory mechanism of Mytilus edulis
... It would appear that the recorded activity represents the activity of those fibres which carry inhibitory impulses to the lateral cilia because there is a graded dose/response relationsh[r] ...
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Lower Esophageal Sphincter Relaxation: Studies on the Neurogenic Inhibitory Mechanism
... acetylcholine produced tension and occurred at 80 V. Upper esophageal and gastric muscle were not inhibited. The inhibitory response of the LES muscle was antagonized by tetrodotoxin and hexamethonium but not by ...
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Csk-homologous kinase (Chk) is an efficient inhibitor of Src-family kinases but a poor catalyst of phosphorylation of their C-terminal regulatory tyrosine
... non-catalytic inhibitory mech- anism, it is not suitable for quantitative analysis to com- pare the efficiencies of the non-catalytic inhibitory mechanism of Csk and ...
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Beneficial Bacillus Strains Improve Plant Resistance to Phytopathogens: A Review
... Rhizopus stolonifer and Verticillium dahliae was possible with lipopeptide antibiotics produced by B.subtilis [19, 20]. When biocontrol bacteria associate antibiotic synthesis with the production of another ...
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Studies on Substituted Thienopyridine Carbonitriles as Src Inhibitors Using a Comprehensive In Silico Method
... and inhibitory mechanism of Src inhibitors, the comparative molecular field analysis, comparative molecular similarity indices analysis and three-dimensional quantitative structure-activity relationship and ...
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Comparing sequence and structure of falcipains and human homologs at prodomain and catalytic active site for malarial peptide based inhibitor design
... prodomain inhibitory mechanism, residue interactions between prodomain and catalytic domain of plasmodial and human partial zymogen com- plexes were evaluated using the Protein Interaction Cal- culator ...
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Autoinhibition of the Ron receptor tyrosine kinase by the juxtamembrane domain
... the inhibitory mechanism imposed by the JM-C region, we compared the kinase domain sequences of 150 receptors by mapping them onto the crystal structure of the Ron kinase domain (3PLS) [48] (Figure ...
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Isolation and characterization of an antifungal compound 5 hydroxy 7,4’ dimethoxyflavone from Combretum zeyheri
... The mechanism of action of 5-hydroxy-7,4 ’ -dimethoxyflavone as a potent antifungal agent was investigated by determining its inhibitory activity on Candida albicans drug efflux pumps using the ...
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IN SILICO MOLECULAR DOCKING STUDIES OF SOME ISOLATED COMPOUNDS FROM NAUCLEA LATIFOLIA FOR Α AMYLASE INHIBITORY ACTIVITY AND ADME/T PROPERTY ANALYSIS OF THE COMPOUNDS
... the mechanism of action of the isolated compounds from Nauclea latifolia was explored the α-amylase inhibitory activity by molecular docking analysis used for five phytoconstituents namely beta-sitosterol, ...
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TAR-independent transactivation of the murine cytomegalovirus major immediate-early promoter by the Tat protein.
... To investigate i the mechanism of the inhibitory effect on gene expression by the farupstream sequences of the MCMV MIEP and ii Tatmediated transactivation of the MCMV MIEP, we transfect[r] ...
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Hormonal Control of Sexual Maturity in Octopus
... The mechanism of hormonal control of gonad maturation in Octopus, a Situation in an immature, unoperated Octopus, where secretion by the optic glands is held in check by an inhibitory ne[r] ...
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Polypyridylruthenium(II) complexes exert in vitro and in vivo nematocidal activity and show significant inhibition of parasite acetylcholinesterases
... their inhibitory effects through a combination of electrostatic and hy- drophobic interactions at the peripheral anionic (PAS) site of AChE, which is located at the gate of the enzyme's catalytic gorge (Bourne et ...
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The Inhibitory Effect of Heme on Heme Formation In Vivo: Possible Mechanism for the Regulation of Hemoglobin Synthesis
... 7) Data are presented to show that the effect of hemin is not by a dilution mechanism nor by a decrease in red cell maturation and subsequent release of reticulocytes into the peripheral blood. The findings are ...
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The Physiology and Computation of Pyramidal Neurons
... of inhibitory input can independently affect somatic and dendritic regions such that the effect of plateau potentials on the soma is reduced without directly changing the properties of the dendritic plateau ...
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Postinfection control by bacteriophage T4 of Escherichia coli recBC nuclease activity.
... In this work we are dealing with a control mechanism involving a host enzyme, namely Escherichia coli recBC DNase, and its interaction with an inhibitory substance induced by bacteriopha[r] ...
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REVIEW ARTICLE Is depression an inflammatory condition? A review of available evidence
... Mood disorders, especially depressive disorders are prevalent, hard to treat and cause considerable morbidity. There is a bidirectional relationship between mood disorders, especially depression and markers of the ...
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Mechanism of the inhibitory effect of ghrelin in sepsis
... the mechanism of action of ghrelin in sepsis, highlight the role ghrelin plays in attenuating the hepatic dysfunction induced by sepsis and septic shock and suggest in developing ghrelin as a potential therapy for ...
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