iNKT cell
Disposal of iNKT cell deficiency and an increase in expression of SLAM signaling factors characterizes sarcoidosis remission: a 4-year longitudinal study
... an iNKT cell deficiency affects their Th1- related immunoregulatory ...lower iNKT cell numbers, which are char- acterized by a Th1-biased hyperactive response, and in which the adoptive ...
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The effect of stimulation with TSLP and KRN7000 on iNKT cell proliferation and cytokine production
... of! iNKT! cells! ...of! iNKT! cells! in! blood! of! healthy! volunteers! was! ...achieved!the!best!iNKT!cell!proliferation.!This!was!followed!by!investigating!iNKT! cell! ...
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Mouse and human iNKT cell agonist β mannosylceramide reveals a distinct mechanism of tumor immunity
... (iNKT) cell agonists, epitomized by α-galactosylceramide, protect against cancer largely by IFN-γ–dependent ...of iNKT cell agonist, with an unusual β-linked ...activates iNKT cells ...
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Adipocytes harbor a glucosylceramide biosynthesis pathway involved in iNKT cell activation
... altered iNKT phe- notype and ultimately reduced iNKT cell numbers ...proper iNKT cell development, proliferation and ...which iNKT cells have been im- plicated ...
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Alterations of the iNKT cell compartment in brain injured patients
... the iNKT compartment, we then unex- pectedly observed a clear over-expression of CD1d both in monocytes and B ...activate iNKT cells in an antigen-dependent ...of iNKT cells using PBMCs from patients ...
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Deficiency of innate-like T lymphocytes in chronic obstructive pulmonary disease
... T cell subsets are in the center of intensive research in this dis- ease [4, ...9]. iNKT and MAIT cells represent unique, unconventional T cell popu- lations characterized by the co-expression of ...
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Activation of human invariant natural killer T cells with a thioglycoside analogue of ? galactosylceramide
... Expanded iNKT cells were co-cultured with mock-transfected or CD1d-transfected C1R cells or the CD1d-positive transformed cells lines Jurkat and THP-1 in the absence or presence of 100 ng/ml α-GalCer or ...the ...
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PubMedCentral-PMC5289534.pdf
... sickle cell disease (SCD), interruption of iNKT cell activity prevents tissue injury from ...anti-iNKT cell monoclonal antibody that has the potential to rapidly and specifically ...
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Spontaneous focal activation of invariant natural killer T (iNKT) cells in mouse liver and kidney
... of iNKT cell behaviour are puzzling: their thy- mic ontogeny and relation to the classical pathways of T-cell mediated differentiation; the relative importance of endogenous and exogenous ligands in ...
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Adipose tissue invariant NKT cells protect against diet induced obesity and metabolic disorder through regulatory cytokine production
... that iNKT cells, previ- ously thought to be rare in humans, were highly en- riched in human and murine adipose tissue, and that as adipose tissue expanded in obesity, iNKT cells were depleted, correlating ...
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Temporal differences in the dependency on Phosphoinositide dependent kinase 1 distinguish the development of V?14 iNKT cells, regulatory T cells and conventional T cells
... of iNKT cell ...mediated iNKT cell ...for iNKT cells and in its absence there is a block in normal iNKT cell development in the thymus whereas the development of ...
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Novel thioglycoside analogs of α galactosylceramide stimulate cytotoxicity and preferential Th1 cytokine production by human invariant natural killer T cells
... of iNKT cells with the xenogeneic glycolipid α -galactosylceramide ( α -GalCer) can prevent and reverse tumor growth in murine models, but clinical trials using α -GalCer-stimulated human iNKT cells have ...
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Induction of antiinflammatory purinergic signaling in activated human iNKT cells
... T cell–intrinsic purinergic regulation, it was previously shown that the phenotypes of DCs also have a strong influence on iNKT cell cytokine ...Th2/IL-4 iNKT cell response to antigen ...
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Type II NKT cell–mediated anergy induction in type I NKT cells prevents inflammatory liver disease
... recruited iNKT cells were anergic and prevented concanavalin A–induced (ConA-induced) hepatitis by specifically blocking effector pathways, including the cytokine burst and neutrophil recruitment that follow ConA ...
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Natural killer T cells in adipose tissue prevent insulin resistance
... Finally, iNKT cells are known to bridge innate and adaptive immunity, as they can rapidly release high doses of immune polar- izing cytokines upon lipid/CD1d complex binding ...stimulation, iNKT cell ...
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Utilizing the adjuvant properties of CD1d dependent NK T cells in T cell–mediated immunotherapy
... of iNKT cell ...by iNKT cell activity (Figure ...and iNKT cell–mediated signals induced significantly greater T cell responses than exposure to either stimulus ...for ...
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Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells
... NK cell, γδ T cell, and CD8+ T cell populations used for comparison to iNKT cells can be found at the ImmGen ...For iNKT cells, thymocytes, splenocytes, liver and lung mononuclear cells ...
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Longitudinal analysis of immune abnormalities in varying severities of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients
... months. iNKT cells had not pre- viously been examined in CFS/ME and the current study found expression of CD62L was significantly increased in moderate CFS/ME patients between 0 and 6 ...in iNKT cells is ...
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Distinct and Overlapping Effector Functions of Expanded Human CD4, CD8? and CD4CD8? Invariant Natural Killer T Cells
... + iNKT cells in freshly-isolated PBMC and among in vitro expanded iNKT cells from healthy donors were examined by flow cytometric analysis of Va24 + Vb11 + CD3 + ...Since iNKT cells generally ...
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Impact of bacteria on the phenotype, functions, and therapeutic activities of invariant NKT cells in mice
... mouse iNKT cells with the gly- colipid α-galactosylceramide (α-GalCer) results in the acquisition of a hyporesponsive (anergic) phenotype by these ...Because iNKT cells can become activated in the context ...
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