iNKT cells
iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions
... of iNKT-1/iNKT-17 dichotomy in TSC1-deficient iNKT ...of iNKT cells in TSC1KO mice allowed us to exam- ine how TSC1 deficiency may affect iNKT effector ...WT iNKT ...
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Induction of antiinflammatory purinergic signaling in activated human iNKT cells
... on iNKT cells (19), is induced as a consequence of ...circulating iNKT cells from 8 healthy con- trols as well as 8 adult SCD patients at steady state and 13 adult SCD patients during acute ...
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Original Article A critical role of CXCR6 in murine myocardial ischemia-reperfusion injury through activating IL-17a producing iNKT cells
... than iNKT cells themselves contributed to the pro- tection against cardiac ischemic injury ...Besides iNKT cells, many other immune cells, such as macro- phages, Th2 cells and B ...
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Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells
... last iNKT cell maturation stage, many of the most strongly upregulated genes belonged to the killer lectin receptor family, which encodes activating and inhibitory NK receptors (NKRs) ...ontogeny, iNKT ...
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Temporal differences in the dependency on Phosphoinositide dependent kinase 1 distinguish the development of V?14 iNKT cells, regulatory T cells and conventional T cells
... of iNKT cell ...mediated iNKT cell ...for iNKT cells and in its absence there is a block in normal iNKT cell development in the thymus whereas the development of conventional Į/ȕ T ...
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Development of genetically engineered iNKT cells expressing TCRs specific for the M tuberculosis 38 kDa antigen
... gene-modified iNKT cells specific- ally killed Mtb antigen-loaded target cells directly by granule-dependent mechanisms, and simultaneously ex- hibited an enhanced regulating function in the early ...
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Spontaneous focal activation of invariant natural killer T (iNKT) cells in mouse liver and kidney
... (iNKT) cells are activated spontaneously in mouse liver and ...tissue cells, namely hepatic parenchymal cells and renal tubular epithelial ...that iNKT cells are rendered ...
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Deficiency of innate-like T lymphocytes in chronic obstructive pulmonary disease
... the iNKT proportions isolated from controls and COPD ...study iNKT cells and not NKT-like cells were analyzed, however the staining combination was different from our approach applying ...
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Type I Interferons Triggered through the Toll-Like Receptor 3–TRIF Pathway Control Coxsackievirus A16 Infection in Young Mice
... host cells in vitro and in vivo upon infection ...(iNKT) cells were later found to be crucial antiviral effector cells to protect young mice from EV71 ...of iNKT cells dependent ...
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Intracellular Bacterial Infection and Invariant NKT Cells
... on iNKT cells even if the marker was ...+ iNKT cells are detected in the liver of recipient re-arrangement gene-1 -/- mice lacking all T cells, including iNKT cells, which ...
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PubMedCentral-PMC5289534.pdf
... (iNKT) cells can be activated to stimulate a broad inflammatory ...of iNKT cell activity prevents tissue injury from ...deplete iNKT cells and, potentially, prevent vaso-occlu- ...
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Natural killer T cells in adipose tissue prevent insulin resistance
... Finally, iNKT cells are known to bridge innate and adaptive immunity, as they can rapidly release high doses of immune polar- izing cytokines upon lipid/CD1d complex binding ...stimulation, iNKT cell ...
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Accumulation of invariant NKT cells with increased IFN-γ production in persistent high-risk HPV-infected high-grade cervical intraepithelial neoplasia
... how iNKT cells function in cervical tissues. INKT cells produce IFN-γ in several diseases ...with iNKT cell accumula- ...that iNKT cells induce a local immune-suppressive ...
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Elevated expression of LAG 3, but not PD 1, is associated with impaired iNKT cytokine production during chronic HIV 1 infection and treatment
... T cells during chronic HIV infection and its expression on innate lymphocyte subsets is not well ...T cells, NK cells and iNKT cells among a cohort of healthy and HIV-infected female ...
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TIM-4 is expressed on invariant NKT cells but dispensable for their development and function
... T cells, mouse hepatic iNKT cells and ...hybridoma cells constitutively expressed TIM-4 and TIM-1 at a substantial level ...DN32.D3 cells in vitro. Hence, we hypothesized that TIM-4 ...
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iNKT/CD1d-antitumor immunotherapy significantly increases the efficacy of therapeutic CpG/peptide-based cancer vaccine
... CD1d-restricted iNKT cells in the transactivation of innate and adaptive immune responses has been well demonstrated [7,23], and several studies have exploited iNKT cells for therapeutic ...
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TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury
... of iNKT cells in vivo requires caspase 1 ...of iNKT cells in vivo, ...in iNKT cells (28–30). As shown in Figure 2A, freshly isolated iNKT cells from the liver ...
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Cytotoxic lymphocytes in COPD airways: increased NK cells associated with disease, iNKT and NKT-like cells with current smoking
... Functionally, iNKT cells are thought to play an important role in the pathogenesis of ...activated iNKT cells in the lungs ...induce iNKT cell ...
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Longitudinal analysis of immune abnormalities in varying severities of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients
... months. iNKT cells had not pre- viously been examined in CFS/ME and the current study found expression of CD62L was significantly increased in moderate CFS/ME patients between 0 and 6 ...in iNKT ...
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Novel thioglycoside analogs of α galactosylceramide stimulate cytotoxicity and preferential Th1 cytokine production by human invariant natural killer T cells
... tumor cells and by releasing soluble factors (cytokines) that selectively activate and regulate other cells of the immune ...antigen-presenting cells (APC). However, some T cells respond to ...
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