Inositol monophosphatase
Loss-of-function mutation in inositol monophosphatase 1 (IMPA1) results in abnormal synchrony in resting-state EEG
... the inositol cycle is implicated in a wide variety of human diseases, including developmental defects and neurological ...enzyme inositol monophosphatase 1 (IMPase), has recently been associated with ...
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Mechanistic and structural studies on myo inositol monophosphatase: the emerging target for lithium therapy
... by inositol monophosphatase, albeit slower than the phosphate versions, is another indication that inositol monophosphatase might operate via an adjacent displacement ...
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Mechanistic studies on myo inositol monophosphatase
... inositol monophosphatase and the inositol cycle have been studied in a variety of tissue types from various sources but the most concentrated research has been conducted with bovine®®»®'* and rat ...
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Synaptic Polarity Depends on Phosphatidylinositol Signaling Regulated by myo-Inositol Monophosphatase in Caenorhabditis elegans
... conserved inositol-producing enzyme myo-inositol monophosphatase (IMPase) is essential for polarized localization of synaptic mol- ecules in Caenorhabditis elegans and can be inhibited by lithium, a ...
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Comparative Genomics of Pneumocystis Species Suggests the Absence of Genes for myo Inositol Synthesis and Reliance on Inositol Transport and Metabolism
... the inositol phosphate me- tabolism pathway compared to that in the fission ...encoding inositol- polyphosphate multikinase (EC 2.7.1.151), inositol-pentakisphosphate 2-kinase (EC ...and ...
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Role of an Expanded Inositol Transporter Repertoire in Cryptococcus neoformans Sexual Reproduction and Virulence
... and inositol monophosphatase were found to be abundant in a SAGE library generated from RNAs isolated during brain infec- tion, suggesting that the myo-inositol internal synthesis pathway is ...
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A biocatalytic approach towards the stereoselective synthesis of protected inositols
... The eukaryotic de novo biosynthesis of myo-inositol (3), shown in Scheme 1, involves the sequential action of two enzymes: L-myo-inositol 1-phosphate synthase (INO1, E.C.5.5.1.4) and myo-inositol ...
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Functional Characterization of Pneumocystis carinii Inositol Transporter 1
... 43). Inositol monophosphatase is one putative target for lithium therapy, one of the primary treatments for bipolar ...myo- inositol transport has not been reported, and the effects on ...
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Two Major Inositol Transporters and Their Role in Cryptococcal Virulence
... high inositol levels found in mammalian brains (38). The inositol concentration in human cerebrospinal fluid (CSF) is around 22 mg/liter, compared to an average ...free inositol (17, 55–58). High ...
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ASSOCIATION BETWEEN THE RS650727 POLYMORPHISM IN MYO-INOSITOL MONOPHOSPHATASE2 (IMPA2) AND BIPOLAR DISORDER IN A TURKISH POPULATION
... 2. Ohnishi T, Kazuo Y, Ohba H, Iwayama Y, Toyota T, Hattori E, Inada T, Kunugi T, Tatsumi M, Ozaki N, Iwata N, Sakamoto K, Iijima Y, Iwata Y, Tsuchiya K J, Sugihara G, Nanko S, Osumi N, Detera Wadleigh S D, Kato T, ...
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A cell factory of Bacillus subtilis engineered for the simple bioconversion of myo-inositol to scyllo-inositol, a potential therapeutic agent for Alzheimer's disease
... the inositol bio- conversion medium (Figure 3A), almost half of the myo - inositol was converted to scyllo ...two inositol isomers; because myo -inositol is pre- ferentially converted to ...
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Benign versus secondary progressive multiple sclerosis: the potential role of proton MR spectroscopy in defining the nature of disability
... of inositol at 3.54 ppm. Inositol was elevated in lesions of both benign and secondary-progressive forms of MS during the acute phase (Fig 1), whereas chronic lesions were characterized by high ...
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Robust Utilization of Phospholipase-Generated Metabolites, Glycerophosphodiesters, by Candida albicans: Role of the CaGit1 Permease
... Several lines of evidence support the notion that GroPIns is transported intact across the plasma membrane via CaGit1, even though a second, CaGit1-independent, mechanism also exists for acquiring phosphate from GroPIns ...
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Copurification of chicken liver soluble thiamine monophosphatase and low molecular weight acid phosphatase
... Thiamine monophosphatase (ThMPase) is an enzyme of thiamine metabolism in animals whose mo- lecular nature has still to be elucidated. In this study we have achieved a 714-fold purification of a soluble enzyme ...
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Properties of deoxynucleoside 5'-monophosphatase induced by bacteriophage T5 after infection of Escherichia coli.
... When 5'-dNMPase activity was measured in the presence of CaCl2 in fractions 20 to 30 from the high-salt buffer column, a peak of activity was found that was comparable to the activity in[r] ...
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Effects of myo-inositol plus alpha-lactalbumin in myo-inositol-resistant PCOS women
... α -LA: α -lactalbumin; BMI: Body mass index; COX 2: Type 2 cyclooxygenase; DCI: D-chiro-inositol; FSH: Follicle-stimulating hormone; GDM: Gestational diabetes mellitus; GLP-2: Glucagon-like peptide-2; HOMA: ...
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<p>Combination of Inositol Hexaphosphate and Inositol Inhibits Liver Metastasis of Colorectal Cancer in Mice Through the Wnt/β-Catenin Pathway</p>
... Phytic acid sodium salt hydrate was purchased from Macklin Biochemical (Shanghai, China). Inositol was pur- chased from Yuanye Biochemical (Shanghai, China). D-Luciferin Potassium Salt was purchased from Solarbio ...
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Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study
... Background: Aim of this pilot study is to examine the effects of myo-inositol administration on ovarian response and oocytes and embryos quality in non PolyCystic Ovary Syndrome (PCOS) patients undergoing multiple ...
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INOSITOL PREVENTS SENESCENCE OF GLADIOLUS FLOWERS
... of inositol treated florets than control ...of inositol decreased the TBARS content and LOX ...with inositol reduced the production of free radicals during progressive senescence hence reduced the ...
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THE RENAL EXCRETION OF INOSITOL BY NORMAL AND DIABETIC RATS
... When insulin was given to diabetic rats in doses adequate to eliminate most of the glucose from the urine, the excretion of inositol was found to be nearly normal.. Inosituria has previo[r] ...
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