Inositol trisphosphate
Enhanced inositol trisphosphate response to alpha 1 adrenergic stimulation in cardiac myocytes exposed to hypoxia
... of inositol trisphosphate was quantified by a novel procedure developed in our laboratory that circumvents problems associated with using labeled ...in inositol trisphosphate levels of three- ...
6
Ambient C1 ions modify rat mesangial cell contraction by modulating cell inositol trisphosphate and Ca2+ via enhanced prostaglandin E2
... mesangial cells showing contraction responding to AII and AVP was decreased from 72 +/- 9 to 33 +/- 10% and from 60 +/- 4 to 24 +/- 11%, respectively. Ca2+ transients induced by AII and AVP, measured in mesangial cells ...
8
Diminished agonist stimulated inositol trisphosphate generation blocks stimulus secretion coupling in mouse pancreatic acini during diet induced experimental pancreatitis
... Young female mice fed a choline-deficient, ethionine-supplemented (CDE) diet rapidly develop acute hemorrhagic pancreatitis. We have observed that pancreatic acini prepared from these mice are unable to secrete amylase ...
8
Endothelin B receptor Ca2+ signaling in shark vascular smooth muscle: participation of inositol trisphosphate and ryanodine receptors
... antagonizes inositol 1,4,5- trisphosphate-induced calcium release, inhibits calcium pumps and has a use-dependent and slowly reversible action on store-operated calcium entry ...
7
Stimulation of inositol trisphosphate and diacylglycerol production in renal tubular cells by parathyroid hormone
... of inositol triphosphate and diacylglycerol production in the opossum kidney cell line, primary culture proximal tubular cells, and basolateral membranes from canine proximal tubular ...in inositol ...
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Mitochondrial ATP production provides long-range control of endothelial inositol trisphosphate–evoked calcium signaling : mitochondrial control of endothelial Ca2+ signaling
... i, composite Ca2⫹ images illustrating Ca2⫹ activity in the same field of endothelial cells during a 1-min period before left and after right pharmacological intervention; each image pair[r] ...
23
Regulation of ion channels by inositol trisphosphate and diacylglycerol
... In these permeabilized cells, the release of calcium from the endoplasmic reticulum by Ins 1,4,5P3 occurs fast enough for it to be able to stimulate various physiological processes such [r] ...
14
Chronic ethanol administration to rats decreases receptor operated mobilization of intracellular ionic calcium in cultured hepatocytes and inhibits 1,4,5 inositol trisphosphate production: relevance to impaired liver regeneration
... such concentrations of ethanol stimulate hydrolysis of mem- brane inositol phosphatides. It should be noted, however, that the nature of hepatocytes studied in suspensions or cultures on some matrices is different ...
9
Pathogenesis of Nonsteroidal Anti-inflammatory Drug (NSAID)-induced Renal Damage.
... iNOS Inducible nitric oxide synthase IP3 Inositol trisphosphate JNK c-Jun N-terminal kinase Keap 1 Kelch-like ECH-associated protein 1 LDH Lactate dehydrogenase LT SDS PAGE Low-temperatu[r] ...
301
Restoration of Na+/H+ exchanger NHE3 containing macrocomplexes ameliorates diabetes associated fluid loss
... We found that the expression of Na+/H+ exchanger NHE3 and several scaffold proteins, including NHE3 regulatory factors NHERFs, inositol trisphosphate IP3 receptor-binding protein release[r] ...
14
Portraying the effect of source influx on interdependent calcium and inositol 1,4,5−trisphosphate dynamics in cardiac myocyte
... Abstract. Calcium governs the most versatile and universal signaling mechanism in living systems which includes contraction of the cardiac tissues, information processing in the brain, release of digestive enzymes by the ...
17
Inositol 1,4,5-trisphosphate receptor type 1 autoantibodies in paraneoplastic and non-paraneoplastic peripheral neuropathy
... ITPR1: Inositol 1,4,5- trisphosphate type 1 receptor; MoL: Molecular layer; MRC: Medical Research Council scale; NMOSD: Neuromyelitis optica spectrum disorders; PBMC: Peripheral blood mononuclear cell; PBS: ...
17
Inositol 1,4,5 trisphosphate may regulate rat brain Cai++ by inhibiting membrane bound Na(+) Ca++ exchanger
... To determine if 1,4,5-IP3 may regulate cell cytosolic Ca++ by acting on plasma membrane bound Na+-Ca++ exchanger, we investigated Ca++ transport in synaptosomes using 45Ca++ as tracer.. [r] ...
6
Neural modulation of salt secretion in teleostopercular epithelium by 2 adrenergic receptors and inositol 1,4,5 trisphosphate
... This research was undertaken to provide evidence for at least partial control of salt secretion in fish via the autonomic nervous system using experiments on isolated opercular epithelia[r] ...
7
Regulation of inositol 1,4,5 trisphosphate kinase activity after stimulation of human T cell antigen receptor
... phosphorylated by a cytoplasmic kinase, yielding inositol 1,3,4,5-tetrakisphosphate (Ins- 1,3,4,5-P3). We observed that stimulation of the antigen receptor on a malignant human T cell line, Jurkat, led to ...
5
Interactions Between the Inositol 1,4,5-Trisphosphate and Cyclic AMP Signaling Pathways Regulate Larval Molting in Drosophila
... Larval molting in Drosophila, as in other insects, is initiated by the coordinated release of the steroid hormone ecdysone, in response to neural signals, at precise stages during development. In this study we have ...
10
Three-dimensional structure of recombinant type 1 inositol 1,4,5-trisphosphate receptor.
... ( C ) Similar class averages obtained after three iterative alignments using the filtered three-dimensional structure of native IP 3 R [23] as a reference for the first alignment.. ( D )[r] ...
9
Regulation of inositol 1,4,5 trisphosphate receptors
... Ins1,4,5P3 is produced at the plasma membrane following receptor activation, but rapidly diffuses into the cytosol, where it binds to specific receptors through which it mobilizes intrac[r] ...
22
Pregnancy block by MHC class I peptides is mediated via the production of inositol 1,4,5 trisphosphate in the mouse vomeronasal organ
... Exposure of C57BL/6 female mice mated with BALB/c males to urine of castrated or juvenile C57BL/6 males resulted in a significant pregnancy failure rate, whereas, exposure to urine of BA[r] ...
7
Inositol 1,4,5 trisphosphate (IP3) dependent Ca2+ signaling mediates delayed myogenesis in Duchenne muscular dystrophy fetal muscle
... As Ryr1 and IP3R belong to the same class of calcium channels and intracellular calcium increase can be mediated by IP3/IP3R binding, we firstly investigated the expression of IP3R in mu[r] ...
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