inotropic effect
Influence of Histidine on the contractility and adrenaline inotropic effect in the experiments with myocardium of right ventricular of Non pregnant and Pregnant Rats
... negative inotropic effect of propranolol and atenolol may lie at least three ...exert effect, which is to stabilize the plasma membrane ...negative inotropic effect when it acts ...
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The negative inotropic effect of beta3 adrenoceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle
... negative inotropic effect through NOS activa- ...net effect of the adrenergic input on car- diac inotropism is likely to be influenced by changes in the ex- pression and coupling of each adrenoceptor ...
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The Mechanics of Esophageal Muscle Contraction EVIDENCE OF AN INOTROPIC EFFECT OF GASTRIN
... minor effect on the maximum velocity of shortening (V ...This inotropic effect of gastrin I occurred at lower concentrations in LES muscle than in muscle from the ...
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β3 adrenoceptor deficiency blocks nitric oxide–dependent inhibition of myocardial contractility
... The negative inotropic effect of β3-adrenoreceptor stimulation is mediated by activation of a nitric oxide synthase pathway in human ventricle.. Functional β3-adrenoceptor in the human h[r] ...
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Calcium Sensitizing and Phosphodiesterase-III Inhibitory Activity of Pyridazine Compounds: A Review
... Receive Date: 19 December 2018, Revise Date: 22 December 2018, Accept Date: 27 December 2018 Abstract: Congestive heart disease is one of the main causes of death in the globe, affecting more than 1% of the world ...
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Molecular and cellular actions of platelet activating factor in rat heart cells
... negative inotropic effect on myocardial tissue; (b) the effects of PAF are mediated by a specific, high affinity cardiac receptor; (c) an underlying biochemical mechanism for the action of PAF includes the ...
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Ryanodine wastes oxygen consumption for Ca2+ handling in the dog heart A new pathological heart model
... negative inotropic effect of RYA at a low concentration (up to 30 +/- 13 nM) on left ventricular (LV) mechanoenergetics using frameworks of LV Emax (a contractility index) and the myocardial oxygen ...
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Role of Tachycardia as an Inotropic Stimulus in Man
... the inotropic effect of tachycardia in nine postsurgical aortocoronary bypass graft patients (with intact cardiac innervation) and nine cardiac allograft recipients (with denervated ...
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The effect of chronic digitoxin administration on the contractile state of normal and nonfailing hypertrophied myocardium
... significantly reduced mortality from heart failure and enhanced the recovery of contractile function; contractile function in the 6 wk banded treated group approached that of untreated control and 24-wk banded groups. ...
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Effects of Acetylcholine on Resting and Action Potentials, and on Contractile Force in the Ventricle Of Dolabella Auricularia
... At these concentrations the negatively inotropic effect of ACh on a beating ventricle Hill, 1964 may be due to an indirect effect on E-C coupling, whereas the positively inotropic and ch[r] ...
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Gentamicin blockade of slow Ca++ channels in atrial myocardium of guinea pigs
... dependence of myocardial fibers on influx of Ca++ through specific "slow channels" of the sarcolemma), the cardiac depressant activity of gentamicin (0.1 mM) was profoundly augmented. Conversely, the negative ...
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Cardiotonic activity of Petrolium Ether and alcoholic extract of Seeds of Cassia Tora Linn.
... Pharmacological effect was studied by using ringer Locke solution and isolated guinea pig ...positive inotropic and negative chronotropic ...positive inotropic and chronotropic ...contraction ...
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Enkephalins increase cyclic adenosine monophosphate content, calcium uptake, and contractile state in cultured chick embryo heart cells
... maximally inotropic concentrations, the 45Ca influx rate increased 39%, adenylate cyclase was stimulated by 30%, and cyclic AMP content rose more than ...positive inotropic effect via a ...
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Reduction of sympathetic inotropic response after ischemia in dogs Contributor to stunned myocardium
... myocardial inotropic response to sympathetic nervous ...myocardial inotropic response to neural stimulation and direct exposure to the sympathetic mediator, ...
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Evaluation of Inotropic Activity of Fluorobenzene Derivative Using an Isolated Rat Heart Model
... Analyzing this hypothesis, in this study the biologic activity of the compound 3 on reperfusion/injury was evaluated using an isolated heart model. The results (Figure 2) showed that the compound 3 reduced infarct size ...
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C-reactive protein/albumin ratio as a predictor of 28 day mortality in patients with sepsis
... Methods: A prospective study was conducted including 150 patients satisfying the criteria for sepsis according to SOFA score of more than 2. Initial CRP/Albumin ratio was assessed to determine its significance in ...
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Colchicine Overdose: Journey to recover. Case Report
... requiring inotropic and vasopressor support and coagulopathy requiring frequent blood and blood products transfusion, acute kidney injury with severe uremia and metabolic acidosis so CRRT (Continuous Renal ...
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Prognosis and risk stratification in patients with decompensated heart failure receiving inotropic therapy
... with inotropic stimulation being the strongest predictor of outcome during hospitalisation (10-fold increased risk of death/heart ...positive inotropic drugs had a fivefold increased risk of composite ...
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REVISITING CARDIOPROTECTIVE ROLE OF CURCUMINOIDS: A COMPARISON OF CARDIAC OUTPUT, POSITIVE INOTROPIC, AND NEGATIVE CHRONOTROPIC EFFECTS IN ISOLATED PERFUSED FROG HEART PREPARATION
... The fact that the curcuminoids dose-dependently reduced the cardiac contractility of isolated frog heart muscle indicates the positive inotropic mechanism of curcuminoids.(Kapakos et al., 2012) During the study, ...
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Pharmacodynamic Studies of Beta Adrenergic Antagonism Induced in Man by Propranolol and Practolol
... practolol, were compared in eight hypertensive patients. The activity of each antagonist was established in relation to its blood concentration at maximal and submaximal adrenergic blockade defined by inhibition of ...
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