INS-1 Cells
Glucose stimulated insulin secretion correlates with changes in mitochondrial and cytosolic Ca2+ in aequorin expressing INS 1 cells
... glucose and KCl while attenuating the CCh response. Glucose-induced increases in [Ca2+]m, [Ca2+]c, and insulin secretion all demonstrate a pronounced initial peak followed by a sustained plateau. All three parameters are ...
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Original Article Inhibiting KDELC1 may prevent palmitate-induced apoptosis in INS-1 cells by reducing ER stress
... in INS-1 cells in order to investigate the effects of FFA on β-cell func- tion and survival in the lipo- toxic ...the INS-1 cell survival rate was reduced to about 50% after incubated ...
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Impact of Bisphenol A (BPA) and Free Fatty Acids (FFA) on Th2 Cytokine Secretion from INS 1 Cells
... As signal transduction PI3K Wortmannin-sensitive and STAT-3/6 Tofacitinib-sensitive are involved in various effects, INS-1 cells release several cytokines due to BPA and FFA attack which[r] ...
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Original Article microRNA-802 is involved in palmitate-induced damage to pancreatic β cells through repression of sirtuin 6
... β cells is still ...the INS-1 rat insulinoma cell line after pal- mitate treatment for 48 ...control cells, palmitate treatment caused a time- and concentration-depen- dent induction of ...
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Hypericin maintians PDX1 expression via the Erk pathway and protects islet β-cells against glucotoxicity and lipotoxicity
... improved INS-1 cell viability under high-glucose and high-fatty-acid conditions by inhibiting glucotoxicity- and lipotoxicity-induced apoptosis and nitric oxide (NO) ...in INS-1 cells ...
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Antagonistic interaction between Nodal and insulin modulates pancreatic β-cell proliferation and survival
... insulin synthesis and secretion, defect insulin signaling is associated with declined β-cell mass and the onset of diabetes, which was well-documented in vitro and in vivo studies [1, 7, 13, 14]. In rodent islets, ...
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The Role of Integrins in Support of Pancreatic Function, Survival and Maturation
... of INS-1 cells, human fetal pancreas, and human adult islets [63, ...islet cells demonstrated that β1 integrin blockade resulted in significantly decreased expression of essential islet genes ...
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Detailed transcriptome atlas of the pancreatic beta cell
... β cells with min- imum impact on gene ...β cells from rat and mouse which does not interfere with normal tran- scription patterns ...β cells, we took advantage of the fact that 88% of the genes ...
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Overexpression of Insig-1 protects β cell against glucolipotoxicity via SREBP-1c
... in INS-1- Insig-1 cells, IRS-2, PDX-1 and GLUT-2 mRNA expres- sions were increased to various degrees compared with control INS-1 ...
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2018_Chandi.pdf
... Previous research has revealed significant expression level changes of miR-29b 146a and 217 with 24 hour iAs III exposure (1 µM) in INS-1 cells (Beck, unpublished 2017) and these same ...
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Role of C-Kit Receptor Tyrosine Kinase on INS-1 Cell VEGF-A Expression in Vitro
... SCF-treated INS-1 cells was found to be increased and transcriptionally active, modulating HIF-1α expression and increasing VEGF-A production (Figure ...
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Evaluation of the hypoglycaemic activity of Bauhinia monandra leaf in Alloxan diabetic rats and INS 1 insulin cells
... The plant, Bauhinia monandra Kurz, (Caesalpinaceae) is an ornamental. Traditionally, the leaves are used in the treatment of diabetes. 4.150 kg of the dried leaves of B. monandra was extracted with methanol (cold ...
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Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL 1beta induced cytotoxicity and reduces nitric oxide production
... in INS-1 cells. The three representative INS-1 cell lines engineered for stable overexpression of Mn- SOD described above were tested for cytokine-induced cyto- toxicity using the MTT ...
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Electrokinetic measurements of membrane capacitance and conductance for pancreatic cells
... islet cells, and those of ...for INS-1 cells, fall within the range of values determined by ER for T-cells ...blood cells were obtained for a single suspending medium ...
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GPS/INS Integration for Vehicle Navigation based on INS Error Analysis in Kalman Filtering
... and INS using different integration approaches ...the INS error, where in the case of a GPS outage, the navigation solution will depend only on the INS, which will be corrected by its correspondent ...
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Specific insulin like peptides encode sensory information to regulate distinct developmental processes
... daf-28, ins-6 and ins-1 play a role in dauer entry (Li et ...daf-28(tm2308), ins-6(tm2416) and ins-1(nr2091). Like wild type, the ins-6 and ins-1 deletion ...
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The ins and outs of UK unemployment
... Sample design also favours the BHPS, in at least four ways. First, the BHPS ‘following rules’ensure that individuals are tracked as they move between households and move address. In contrast, the LFS samples by address ...
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Ins and outs of Spiralian gastrulation
... vegetal cells (vc) buckle into the blastocoel (bc) to form the archenteron (ar), which remains open via the blastopore ...the cells are cuboidal (arrow), while at late stages of epiboly (I) some of them ...
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Health Ins Booklet Plan 1
... The Summary of Benefits and Coverage (SBC) document will help you choose a health plan. The SBC shows you how you and the plan would share the cost for covered health care services. NOTE: Information about the cost of ...
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Effects of zinc supplementation and zinc chelation on in vitro β cell function in INS 1E cells
... The pivotal role of Zn 2+ in the regulation of insulin se- cretion is also reflected by the chelation experiments using TPEN. TPEN preferentially chelates free Zn 2+ , but also depletes zinc ions that are tightly bound ...
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