Insulin Antibodies
Galantamine Attenuates Type 1 Diabetes and Inhibits Anti-Insulin Antibodies in Nonobese Diabetic Mice
... Type 1 diabetes in mice is characterized by autoimmune destruction of insulin-producing pancreatic β -cells. Disease patho- genesis involves invasion of pancreatic islets by immune cells, including macrophages and ...
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Hyperinsulinemic hypoglycemia associated with insulin antibodies caused by exogenous insulin analog
... of insulin antibody-associated immunological hypoglycemia was an 11 cases report from China ...with insulin antibodies shall not be neglected in insulin-treated patients and if unexpectedly ...
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A novel treatment of hyperinsulinemic hypoglycemia induced by insulin antibodies with alkali administration: a case report
... by insulin analogs that had lower affinity and higher capacity against ...going insulin treatment and rarely cause hyperglycemia or hypoglycemia, because these antibodies usually have low capacity or ...
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COMPARATIVE BINDING OF BEEF AND HUMAN INSULIN TO INSULIN ANTIBODIES PRODUCED IN MAN AND GUINEA PIGS
... Beef insulin was used as the reference standard by Grodsky and Forsham 1 because a human insulin of sufficient purity to allow determination of its specific insulin content by biological[r] ...
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The effects of liraglutide on both hypereosinophilic insulin allergy and the characteristics of anti insulin antibodies in type 2 diabetes mellitus: a case report
... of insulin lis- pro and not after insulin ...human insulin- specific immunoglobulin E (IgE; ...with insulin allergy and was switched from insulin lispro plus glargine to insulin ...
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Nonprecipitating Insulin Antibodies
... The fact that precipitation of the I131 insulin-HGG complex by AHGG did not result in an increase in the amount of free insulin indicates that precipitation of the complex does not resul[r] ...
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The Role of Nonprecipitating Insulin Antibodies in Diabetes
... Insulin binding of sera from insulin treated patients whose insulin had been discontinued, Daily dose of insulin in units Most Highest Lowest recent.. Insulin binding per cent.[r] ...
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Enhancement of postprandial endogenous insulin secretion rather than exogenous insulin injection ameliorated insulin antibody-induced unstable diabetes: a case report
... changing insulin formulations is oc- casionally effective for decreasing insulin antibody levels and improving glycemic control ...an insulin-treated patient with the “IAS-like” insu- lin ...
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Bone marrow increases human islets insulin positive cells in co culture: quantification with flow cytometry
... against insulin, proinsulin, or insulin + ...for insulin occurs at a 1:100 dilution of anti-insulin antibody, at 1:200 of anti-proinsulin antibody, and 1:100 dilution of anti-insulin + ...
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Characterization of circulating insulin and proinsulin binding antibodies in autoimmune hypoglycemia
... have insulin antibodies in the absence of previously documented ...of insulin to the autoantibodies revealed two classes of binding sites with association constants and binding capacities analogous ...
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Detection of Anti-rubella virus, Cytomegalovirus and Chlamydia pneumonia antibodies in patients with type I diabetes mellitus
... both insulin secretion and insulin action whose complex interaction leads to a progressive increase of plasma glucose levels ...anti-insulin antibodies were found in 50-80% of diabetic ...
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Poor glycemic control attributable to insulin antibody in a fulminant type 1 diabetes patient under hemodialysis: successful treatment with double filtration plasmapheresis and prednisolone
... In general, while the pathogenesis of fulminant type 1 diabetes remains unknown, this is a subtype of non- autoimmune, fulminant disorder characterized by a re- markably abrupt onset (exhibiting hyperglycemia and ...
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Insulin effect on glucose transport in thymocytes and splenocytes from rats with metabolic syndrome
... by insulin in lymphocytes is important, since the way they increase inflammation and susceptibility to infections are common in ...by insulin, and the role of three glucose transporters (Gluts) in control ...
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Direct Demonstration of Separate Receptors for Growth and Metabolic Activities of Insulin and Multiplication stimulating Activity (an Insulinlike Growth Factor) Using Antibodies to the Insulin Receptor
... inhibited insulin binding by 90%, whereas it inhibited MSA binding ...of insulin receptors. Blockade of insulin receptors with Fab fragments produced a 30-fold rightward shift in the dose response ...
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Glucose transporter levels in spontaneously obese (db/db) insulin resistant mice
... severely insulin resistant, evidenced by hyperglycemia (plasma glucose 683 +/- 60 ...specific antibodies, was not different in five insulin-sensitive tissues including diaphragm, heart, red and white ...
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Prevalence of autoantibodies to the 65 and 67 kD isoforms of glutamate decarboxylase in insulin dependent diabetes mellitus
... GADs antibodies to GAD65 were detected in 13/15 (87%) islet cell antibody (ICA)-positive and in 1/35 ...GAD67 antibodies were positive only in five (33%) of the ICA-positive relatives (P < ...IDDM ...
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Quantitative assay using recombinant human islet glutamic acid decarboxylase (GAD65) shows that 64K autoantibody positivity at onset predicts diabetes type
... electrophoresis, but converted to one under stronger reduction. Immunoprecipitation was linear with respect to antibody or antigen concentration. In 120 population-based diabetic patients of all ages grouped by treatment ...
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Reduced endogenous insulin secretion in diabetic patients with low titer positive antibodies against GAD
... GAD antibodies and/ or C-peptide immunoreactivity in 24 hour urine collec- tion (uCPR) were not ...influence insulin resis- tance. The patients were divided into insulin secre- tagogue (n = 231) and ...
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Dynamical models for diabetes: insights into insulin resistance and type 1 diabetes
... lower insulin sensitivity ...plasma insulin and glucose concentrations during the 292 Kcal MMTs and during the 600 Kcal MMT, calculated as the average ( ± SEM) of the insulin and glucose ...
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Needle-free insulin drug delivery
... companies have been conducting pilot trials in the effort to develop an insulin pill as a potential alternative to injected or pumped insulin. The attempt requires the development of novel delivery ...
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