Insulin content
Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation
... between insulin secretion and insulin ...stimulates insulin release, there is a rapid and corresponding glucose- induced increase in proinsulin biosynthesis at the translational level that ...
9
Neuronatin regulates pancreatic β cell insulin content and secretion
... in insulin SP cleavage and GSIS (Figures 1–5), we further examined the reg- ulation of Nnat expression by ...mean insulin secretion per unit cellular ...total insulin content in cell ...
14
Pancreatic Insulin Content in Severe Erythroblastosis Fetalis
... hyperplasia in infants with EF is correlated with increased pancreatic insulin content, simi-. lar to that observed in infants of diabetic mothers[r] ...
5
CNX-011-67, a novel GPR40 agonist, enhances glucose responsiveness, insulin secretion and islet insulin content in n-STZ rats and in islets from type 2 diabetic patients
... islet insulin content and modest increase in area of insulin positive cells observed after 12 weeks treatment with CNX-011-67 most likely occurs due to a synergy resul- ting from a coordinated ...
15
MEASUREMENT OF SMALL QUANTITIES OF INSULIN LIKE ACTIVITY WITH RAT ADIPOSE TISSUE IV SERUM INSULIN LIKE ACTIVITY AND TUMOR INSULIN CONTENT IN PATIENTS WITH FUNCTIONING ISLET CELL TUMORS
... Of Whereas 12 normal subjects showed a significant interest is the low extractable insulin content in increase, most marked at 20 minutes after infu- pancreas adjacent to the tumor in tw[r] ...
9
EVIDENCE FOR THE PRESENCE OF INSULIN IN BLOOD SERUM A METHOD FOR AN APPROXIMATE DETERMINATION OF THE INSULIN CONTENT OF BLOOD
... diaphragm to investigate the possibility of a toxic effect of in serum from Patient K during coma the ketone bodies in coma serum on the glucose and after recovery utilization, the exper[r] ...
11
Effects of tacrolimus (FK506) on human insulin gene expression, insulin mRNA levels, and insulin secretion in HIT T15 cells
... on insulin gene expression in the b cell which would then lead to decreased insulin synthesis and ...lower insulin secretion. De- creased insulin secretion was accompanied by a decline in HIT ...
9
Impaired glucose homeostasis in transgenic mice expressing the human transient neonatal diabetes mellitus locus, TNDM
... of insulin-positive structures (and thus β cell mass) but normal pancreatic insulin ...in insulin secretory capacity and/ or improvement of other regulatory factors may contribute to the remission ...
11
Adaptation to supraphysiologic levels of insulin gene expression in transgenic mice: evidence for the importance of posttranscriptional regulation
... human insulin, showed that the excess insulin mRNA was due solely to expression of the foreign, human insulin ...mouse insulin I and II was unaffected by coexpression of human ...of ...
10
COMPARATIVE BINDING OF BEEF AND HUMAN INSULIN TO INSULIN ANTIBODIES PRODUCED IN MAN AND GUINEA PIGS
... Beef insulin was used as the reference standard by Grodsky and Forsham 1 because a human insulin of sufficient purity to allow determination of its specific insulin content by biological[r] ...
5
The AMP activated protein kinase α2 catalytic subunit controls whole body insulin sensitivity
... cages (Marty Technologie, Paris, France) that allow free access to tap water and food. Body composition analy- sis was performed on anesthetized living mice by a dual-energy x-ray absorptiometry method using a small ...
9
Effect of a combination of arterial hypertension and insulin resistance on hemostasis activity
... have content increase of biologically active substances in platelets and number increase of different receptors on their ...the content of fibrinogen, VII, VIII, IX factors of coagulation, von Willebrand’s ...
5
Anti-Hyperglycemic Effect of Aqueous and Ethanolic Extracts of Leaf and Stem Bark of AlangiumSalvifolium (L.F.) Wang in Alloxan Induced Diabetic Rats
... After 28 days of treatment ,blood was collected retro orbitally from the inner canthus of the eye under light ether anesthesia using capillary tubes.Blood was collected in fresh plasma tubes coated with EDTA, and Plasma ...
5
Partial pancreatectomy in the rat and subsequent defect in glucose induced insulin release
... plasma insulin concentrations compared with sham-pancreatectomized ...remnant content of insulin, glucagon, and ...the insulin responses to glucose were blunted or absent but the responses ...
11
DNA methylation directs functional maturation of pancreatic β cells
... Immunofluorescence staining and morphometric analysis, β galac- tosidase staining, and antibodies. Standard immunofluorscence proto- col was used for immunodetection of various proteins in pancreatic sections (64). ...
11
The Glucagon Content of Crystalline Insulin Preparations
... Instead of using the net blood sugar rise as a measure for activity, it is advantageous to use the quotient, obtained by dividing the net maximum increase following injection of the samp[r] ...
6
Needle-free insulin drug delivery
... of insulin inhaler (Exubera) in 2002 in partnership with Pfizer ...that insulin powder is delivered deep into the lungs, where it is easily absorbed into the bloodstream, in a hand-held inhalation ...the ...
6
G protein–coupled receptor 21 deletion improves insulin sensitivity in diet induced obese mice
... Our results clearly showed that Gpr21 deletion in macrophages substantially compromised the ability of those cells to undergo migration toward the chemokine-enriched CM harvested from the adipocytes or toward MCP-1 in ...
11
Conformational flexibility of the pharmacologically important insulin analogues
... of insulin, a number of advances have been made to allow patients to mimic the normal pattern of insulin release more accurately and conven- ...However, insulin therapy needs to improve still further ...
6
Dynamical models for diabetes: insights into insulin resistance and type 1 diabetes
... lower insulin sensitivity ...plasma insulin and glucose concentrations during the 292 Kcal MMTs and during the 600 Kcal MMT, calculated as the average ( ± SEM) of the insulin and glucose ...
135