Insulin degludec
A practical guide to the interpretation of PK/PD profiles of longer-acting analogue insulins. Part two: Insulin degludec vs. insulin glargine U300
... Glucose clamp studies form an integral part of the early development of insulin therapies. Data generated in these studies are used to establish pharmacokinetic (PK) and pharmacodynamic (PD) profiles of the ...
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A meta-analysis of rate ratios for nocturnal confirmed hypoglycaemia with insulin degludec vs. insulin glargine using different definitions for hypoglycaemia
... with insulin degludec is consistent across different ...the insulin preparation influenced the treatment difference, by considering rate ratios in the maintenance period, and finally whether the ...
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Combination therapies in the management of type 2 diabetes: the use of insulin degludec/liraglutide
... basal insulin degludec provides many potential benefits of diminishing some of the main side effects associated with basal insulin alone, such as weight loss and ...basal insulin allows for ...
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Insulin Degludec 200 Units/mL Is Associated With Lower Injection Frequency and Improved Patient-Reported Outcomes Compared With Insulin Glargine 100 Units/mL in Patients With Type 2 Diabetes Requiring High-Dose Insulin
... creases insulin resistance, leading to a requirement for high doses of basal insulin to achieve glycemic targets ...3a insulin degludec (IDeg) clinical program indicate that ~20% of patients ...
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Real-world efficacy and safety of insulin degludec with mealtime rapid-acting insulin in type 1 diabetes in Indian pediatric population
... acting Insulin degludec along with rapid acting mealtime insulin (Aspart/Lispro/Gluli- sine) for at least 26 weeks and maintained blood glucose diary with atleast 3 point SMBG daily, and have ...
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Heart failure with insulin degludec versus glargine U100 in patients with type 2 diabetes at high risk of cardiovascular disease: DEVOTE 14
... trials; Degludec: insulin degludec; DEVOTE: Trial Comparing Cardiovascular Safety of Insulin Degludec versus Insulin Glargine in Patients with Type 2 Diabetes at High Risk of ...
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Cost-effectiveness of insulin degludec versus insulin glargine U100 in adults with type 1 and type 2 diabetes mellitus in Bulgaria
... outcomes trial DEVOTE showed that insulin degludec was non-inferior to insulin glargine in terms of major adverse cardiovascular events [58]. The clinical trials which informed this analysis used a ...
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United States experience of insulin Degludec alone or in combination for type 1 and type 2 diabetes
... Abstract: Insulin degludec has been the product of a sophisticated and systematic biochemical engineering program which began with the release of insulin ...basal insulin with low individual ...
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Compared with insulin glargine, insulin degludec narrows the day to day variability in the glucose lowering effect rather than lowering blood glucose levels
... basal insulin that is currently being used ...way insulin works differs day by day, blood glucose levels, even when measured at the same point in the day, fluctu- ate ...drug insulin degludec ...
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Twice-daily insulin degludec/insulin aspart effectively improved morning and evening glucose levels and quality of life in patients previously treated with premixed insulin: an observational study
... that uncontrollable hypoglycemia, especially nocturnal hypoglycemia, was a major concern among insulin users and that IDegAsp slightly reduced this concern. IDegAsp might potentially increase confidence with the ...
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Insulin degludec is not associated with a delayed or diminished response to hypoglycaemia compared with insulin glargine in type 1 diabetes: a double-blind randomised crossover study
... current insulin therapy by producing pharmacokinet- ic and pharmacodynamic profiles that more closely resemble physiological insulin ...long-acting insulin analogues has been shown to reduce rates of ...
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Long-term safety and efficacy of insulin degludec in the management of type 2 diabetes
... basal insulin analog, insulin degludec (IDeg), and its various preparations in combination with aspart insulin (IDegAsp) and with liraglutide (IDegLira) for the treatment of adults with ...
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Patient safety and minimizing risk with insulin administration – role of insulin degludec
... outcomes. Insulin degludec is a new basal insulin with an ultra-long duration of action and a mechanism of protraction that induces a flat and stable action profile with low ...variability. ...
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The effect of insulin degludec on risk of symptomatic nocturnal hypoglycaemia in adults with type 1 diabetes and high risk of nocturnal severe hypoglycaemia (the HypoDeg trial): study rationale and design
... Insulin degludec is a newer long-acting basal insulin with a half-life of more than 24 h ...than insulin glargine U100 – a coefficient of variation (CV) of 21% versus 83%, respectively ...with ...
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Safety and Efficacy of Insulin Degludec/Liraglutide (IDegLira) and Insulin Glargine U100/Lixisenatide (iGlarLixi), Two Novel Co-Formulations of a Basal Insulin and a Glucagon-Like Peptide-1 Receptor Agonist, in Patients With Diabetes Not Adequately Controlled on Oral Antidiabetic Medications
... because insulin was for many years the major next step in in- tensification when diabetes was un- controlled on multiple oral agents, insulin therapy became somewhat synonymous with intensification ...with ...
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Insulin degludec/insulin aspart combination for the treatment of type 1 and type 2 diabetes
... mellitus. Insulin therapy represents a cornerstone in the treatment of diabetes and has been used widely for achieving glycemic ...Moreover, insulin treatment, especially if intensive, may be associated ...
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Effect of Insulin Degludec Versus Insulin Glargine U100 on Hypoglycemia in Hispanic Patients With Type 2 Diabetes: Results From the SWITCH 2 Trial
... of degludec and glargine U100 at the end of treatment observed in Hispanic versus non-Hispanic patients highlight the potential for greater insulin resistance in Hispanic ...lower insulin sensitivity ...
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Lower rates of hypoglycaemia in older individuals with type 2 diabetes using insulin degludec versus insulin glargine U100 : results from SWITCH 2
... basal insulin, with or without oral antidiabetic drugs, were randomized 1:1 to receive degludec (Novo Nordisk, Bagsværd, Denmark) once daily and glargine U100 (Sanofi, Paris, France) once daily, in a ...
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Insulin degludec as an ultralong-acting basal insulin once a day: a systematic review
... were given IDeg once-daily for 6 days, with a washout period of 13 to 21 days between treatments. Following dosing on day 6, subjects underwent a euglycemic glucose clamp study. PK samples were taken up to 120 hours ...
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When insulin degludec enhances quality of life in patients with type 2 diabetes: a qualitative investigation
... Case report forms were completed by the investigator (selection criteria, diagnosis, last basal insulin, diabetes- related treatment [oral and injectable], comorbidities). A socio-demographic form was completed by ...
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